Predictors of Pathological Gastroesophageal Reflux among Emirati Patients with Reflux Symptoms Who Undergo Wireless pH Monitoring

Predictors of Pathological Gastroesophageal Reflux among Emirati Patients with Reflux Symptoms Who Undergo Wireless pH Monitoring

Diagnosis of gastroesophageal reflux disease (GERD) relies on recognizing symptoms of reflux and mucosal changes during esophagogastroduodenoscopy. The desired response to acid suppression therapy is reliable resolution of GERD symptoms; however, these are not always reliable, hence the need for pH...

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Bibliographic Details
Published in:Middle East journal of digestive diseases Vol. 15; no. 4; pp. 242 - 248
Main Authors: Shehata, Mostafa Ahmed, Malik, Talaha Aziz, Alzaabi, Mona Hassan Jasem, Ali, Ameirah Bader Abdullah Al, Tenaiji, Khalifa Saleh Ahmed Al, Singh, Yashbir, Wallace, Michael Bradley
Format: Journal Article
Language:English
Published: Iran Shiraz University of Medical Sciences 01-10-2023
Iranian Association of Gastroerterology and Hepatology
Subjects:
Acids
Age
Anti-inflammatory agents
Body mass index
Clinical outcomes
Endoscopy
Epidemiology
Esophagus
Gastroesophageal reflux
Hernias
Nonsteroidal anti-inflammatory drugs
Original
Overweight
Pathology
Patients
Regression analysis
Wireless PH capsule
DeMeester score
Epidemiology
Gastroesophageal reflux disease
Age
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Summary:Diagnosis of gastroesophageal reflux disease (GERD) relies on recognizing symptoms of reflux and mucosal changes during esophagogastroduodenoscopy. The desired response to acid suppression therapy is reliable resolution of GERD symptoms; however, these are not always reliable, hence the need for pH testing in unclear cases. Our objective was to identify potential predictors of a high DeMeester score among patients with potential GERD symptoms to identify patients most likely to have pathological GERD. We conducted a retrospective case-control study on patients who underwent wireless pH monitoring from January 2020 to April 2022. Cases were patients with a high DeMeester score (more than 14.7), indicating pathological reflux, and controls were those without. We collected clinical and demographic data, including age, sex, body mass index (BMI), smoking status, non-steroidal anti-inflammatory drugs (NSAIDs) use, and presence of atypical symptoms. 86 patients were enrolled in the study. 46 patients with high DeMeester scores were considered cases, and 40 patients with DeMeester scores less than 14.7 were considered controls. Esophagitis (grade A) was found in 41.1% of the cases and in 22.5% of the control group. In our study, age of more than 50 years compared with age of 20-29 years and being overweight appeared to be predictors of true pathological reflux among patients with reflux symptoms who underwent wireless pH monitoring. Age above 50 years compared with age between 20-29 years and being overweight appeared to be predictors of true pathological reflux among patients with reflux symptoms who underwent wireless oesophageal pH monitoring. The presence of oesophagitis was approximately four times more likely to be associated with true pathological reflux.
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ISSN:2008-5230
2008-5249
DOI:10.34172/mejdd.2023.353