Search Results - "Malik, Sebastian"

In vitro glycoengineering of IgG1 and its effect on Fc receptor binding and ADCC activity by Thomann, Marco, Schlothauer, Tilman, Dashivets, Tetyana, Malik, Sebastian, Avenal, Cecile, Bulau, Patrick, Rüger, Petra, Reusch, Dietmar

“…The importance and effect of Fc glycosylation of monoclonal antibodies with regard to biological activity is widely discussed and has been investigated in…”
Get full text

Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody by Falck, David, Thomann, Marco, Lechmann, Martin, Koeleman, Carolien A M, Malik, Sebastian, Jany, Cordula, Wuhrer, Manfred, Reusch, Dietmar

“…Good pharmacokinetic (PK) behavior is a key prerequisite for sufficient efficacy of therapeutic monoclonal antibodies (mAbs). Fc glycosylation is a critical…”
Get full text

Interaction analysis of glycoengineered antibodies with CD16a: a native mass spectrometry approach by Hajduk, Joanna, Brunner, Cyrill, Malik, Sebastian, Bangerter, Jana, Schneider, Gisbert, Thomann, Marco, Reusch, Dietmar, Zenobi, Renato

“…Minor changes in the quality of biologically manufactured monoclonal antibodies (mAbs) can affect their bioactivity and efficacy. One of the most important…”
Get full text

Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model by Falck, David, Lechmann, Martin, Momčilović, Ana, Thomann, Marco, Koeleman, Carolien A M, Jany, Cordula, Malik, Sebastian, Wuhrer, Manfred, Reusch, Dietmar

“…A relatively low clearance is one of the prominent favorable features of immunoglobulin G1-based therapeutic monoclonal antibodies (mAbs). Various studies have…”
Get full text

The Impact of Immunoglobulin G1 Fc Sialylation on Backbone Amide H/D Exchange by Kuhne, Felix, Bonnington, Lea, Malik, Sebastian, Thomann, Marco, Avenal, Cecile, Cymer, Florian, Wegele, Harald, Reusch, Dietmar, Mormann, Michael, Bulau, Patrick

“…The usefulness of higher-order structural information provided by hydrogen/deuterium exchange-mass spectrometry (H/DX-MS) for the structural impact analyses of…”
Get full text

Implementation of in vitro glycoengineering of monoclonal antibodies into downstream processing of industrial production by Malik, Sebastian, Grunert, Ingrid, von Roman, Matthias Freiherr, Walch, Heiko, Dams, Thomas, Thomann, Marco, Falkenstein, Roberto

“…In vitro glycoengineering using exoenzymes for specific modification is recognized as appropriate method to tailor sugar moieties of glycan structures during…”
Get full text

Effects of sialic acid linkage on antibody-fragment crystallizable receptor binding and antibody dependent cytotoxicity depend on levels of fucosylation/bisecting by Thomann, Marco, Malik, Sebastian, Kuhne, Felix, Avenal, Cecile, Plath, Friederike, Bonnington, Lea, Reusch, Dietmar, Bulau, Patrick, Cymer, Florian

“… Fragment crystallizable (Fc) glycosylation of immunoglobulin G-type monoclonal antibodies applied to therapeutic applications is regarded a critical quality…”
Get full text

Two N-terminally truncated variants of human β-galactoside α2,6 sialyltransferase I with distinct properties for in vitro protein glycosylation by Luley-Goedl, Christiane, Schmoelzer, Katharina, Thomann, Marco, Malik, Sebastian, Greif, Michael, Ribitsch, Doris, Jung, Christine, Sobek, Harald, Engel, Alfred, Mueller, Rainer, Schwab, Helmut, Nidetzky, Bernd

“…Sialic acid groups of protein N-glycans are important determinants of biological activity. Exposed at the end of the glycan chain, they are potential targets…”
Get full text

In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity: e0134949 by Thomann, Marco, Schlothauer, Tilman, Dashivets, Tetyana, Malik, Sebastian, Avenal, Cecile, Bulau, Patrick, Rueger, Petra, Reusch, Dietmar

“…The importance and effect of Fc glycosylation of monoclonal antibodies with regard to biological activity is widely discussed and has been investigated in…”
Get full text

Rec. ST6Gal-I variants to control enzymatic activity in processes of in vitro glycoengineering by Engel, Alfred M, Sobek, Harald, Greif, Michael, Malik, Sebastian, Thomann, Marco, Jung, Christine, Reusch, Dietmar, Ribitsch, Doris, Zitzenbacher, Sabine, Luley, Christiane, Schmoelzer, Katharina, Czabany, Tibor, Nidetzky, Bernd, Schwab, Helmut, Mueller, Rainer

“…Doc number: P110…”
Get full text

Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model by Falck, David, Lechmann, Martin, Momčilović, Ana, Thomann, Marco, Koeleman, Carolien A. M., Jany, Cordula, Malik, Sebastian, Wuhrer, Manfred, Reusch, Dietmar

“…A relatively low clearance is one of the prominent favorable features of immunoglobulin G1-based therapeutic monoclonal antibodies (mAbs). Various studies have…”
Get full text

Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody by Falck, David, Thomann, Marco, Lechmann, Martin, Koeleman, Carolien A. M., Malik, Sebastian, Jany, Cordula, Wuhrer, Manfred, Reusch, Dietmar

“…Good pharmacokinetic (PK) behavior is a key prerequisite for sufficient efficacy of therapeutic monoclonal antibodies (mAbs). Fc glycosylation is a critical…”
Get full text

Interaction analysis of glycoengineered antibodies with CD16a: a native mass spectrometry approach by Hajduk, Joanna, Brunner, Cyrill, Malik, Sebastian, Bangerter, Jana, Schneider, Gisbert, Thomann, Marco, Reusch, Dietmar, Zenobi, Renato

“…Minor changes in the quality of biologically manufactured monoclonal antibodies (mAbs) can affect their bioactivity and efficacy. One of the most important…”
Get full text