Search Results - "Malik, Radek"

Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs by Loubalova, Zuzana, Fulka, Helena, Horvat, Filip, Pasulka, Josef, Malik, Radek, Hirose, Michiko, Ogura, Atsuo, Svoboda, Petr

“…PIWI-interacting RNAs (piRNAs) support the germline by suppressing retrotransposons. Studies of the pathway in mice have strongly shaped the view that…”
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A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes by Flemr, Matyas, Malik, Radek, Franke, Vedran, Nejepinska, Jana, Sedlacek, Radislav, Vlahovicek, Kristian, Svoboda, Petr

“…In mammals, a single Dicer participates in biogenesis of small RNAs in microRNA (miRNA) and RNAi pathways. In mice, endogenous RNAi is highly active in…”
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Functional and Biochemical Characterization of Human Eukaryotic Translation Initiation Factor 3 in Living Cells by Wagner, Susan, Herrmannová, Anna, Malík, Radek, Peclinovská, Lucie, Valášek, Leoš Shivaya

“…The main role of the translation initiation factor 3 (eIF3) is to orchestrate formation of 43S-48S preinitiation complexes (PICs). Until now, most of our…”
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Long terminal repeats power evolution of genes and gene expression programs in mammalian oocytes and zygotes by Franke, Vedran, Ganesh, Sravya, Karlic, Rosa, Malik, Radek, Pasulka, Josef, Horvat, Filip, Kuzman, Maja, Fulka, Helena, Cernohorska, Marketa, Urbanova, Jana, Svobodova, Eliska, Ma, Jun, Suzuki, Yutaka, Aoki, Fugaku, Schultz, Richard M, Vlahovicek, Kristian, Svoboda, Petr

“…Retrotransposons are "copy-and-paste" insertional mutagens that substantially contribute to mammalian genome content. Retrotransposons often carry long…”
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Restricted and non-essential redundancy of RNAi and piRNA pathways in mouse oocytes by Taborska, Eliska, Pasulka, Josef, Malik, Radek, Horvat, Filip, Jenickova, Irena, Jelić Matošević, Zoe, Svoboda, Petr

“…Germline genome defense evolves to recognize and suppress retrotransposons. One of defensive mechanisms is the PIWI-associated RNA (piRNA) pathway, which…”
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MicroRNA Activity Is Suppressed in Mouse Oocytes by Ma, Jun, Flemr, Matyas, Stein, Paula, Berninger, Philipp, Malik, Radek, Zavolan, Mihaela, Svoboda, Petr, Schultz, Richard M.

“…MicroRNAs (miRNAs) are small endogenous RNAs that typically imperfectly base pair with 3′ untranslated regions (3′UTRs) and mediate translational repression…”
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De novo emergence, existence, and demise of a protein-coding gene in murids by Petrzilek, Jan, Pasulka, Josef, Malik, Radek, Horvat, Filip, Kataruka, Shubhangini, Fulka, Helena, Svoboda, Petr

“…Genes, principal units of genetic information, vary in complexity and evolutionary history. Less-complex genes (e.g., long non-coding RNA (lncRNA) expressing…”
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The most abundant maternal lncRNA Sirena1 acts post-transcriptionally and impacts mitochondrial distribution by Ganesh, Sravya, Horvat, Filip, Drutovic, David, Efenberkova, Michaela, Pinkas, Dominik, Jindrova, Anna, Pasulka, Josef, Iyyappan, Rajan, Malik, Radek, Susor, Andrej, Vlahovicek, Kristian, Solc, Petr, Svoboda, Petr

“…Abstract Tens of thousands of rapidly evolving long non-coding RNA (lncRNA) genes have been identified, but functions were assigned to relatively few of them…”
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Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR–eIF4F pathway by Susor, Andrej, Jansova, Denisa, Cerna, Renata, Danylevska, Anna, Anger, Martin, Toralova, Tereza, Malik, Radek, Supolikova, Jaroslava, Cook, Matthew S., Oh, Jeong Su, Kubelka, Michal

“…The fully grown mammalian oocyte is transcriptionally quiescent and utilizes only transcripts synthesized and stored during early development. However, we find…”
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An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation by Sinigaglia, Ketty, Cherian, Anna, Du, Qiupei, Lacovich, Valentina, Vukić, Dragana, Melicherová, Janka, Linhartova, Pavla, Zerad, Lisa, Stejskal, Stanislav, Malik, Radek, Prochazka, Jan, Bondurand, Nadège, Sedláček, Radislav, O’Connell, Mary A., Keegan, Liam P.

“…Adar null mutant mouse embryos die with aberrant double-stranded RNA (dsRNA)-driven interferon induction, and Adar Mavs double mutants, in which interferon…”
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Reporters transiently transfected into mammalian cells are highly sensitive to translational repression induced by dsRNA expression by Nejepinska, Jana, Malik, Radek, Wagner, Susan, Svoboda, Petr

“…In mammals, double-stranded RNA (dsRNA) can mediate sequence-specific RNA interference, activate sequence-independent interferon response, or undergo RNA…”
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C/EBPγ Suppresses Senescence and Inflammatory Gene Expression by Heterodimerizing with C/EBPβ by Huggins, Christopher J., Malik, Radek, Lee, Sook, Salotti, Jacqueline, Thomas, Sara, Martin, Nancy, Quiñones, Octavio A., Alvord, W. Gregory, Olanich, Mary E., Keller, Jonathan R., Johnson, Peter F.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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dsRNA expression in the mouse elicits RNAi in oocytes and low adenosine deamination in somatic cells by Nejepinska, Jana, Malik, Radek, Filkowski, Jody, Flemr, Matyas, Filipowicz, Witold, Svoboda, Petr

“…Double-stranded RNA (dsRNA) can enter different pathways in mammalian cells, including sequence-specific RNA interference (RNAi), sequence-independent…”
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Deep sequencing reveals complex spurious transcription from transiently transfected plasmids by Nejepinska, Jana, Malik, Radek, Moravec, Martin, Svoboda, Petr

“…Transient plasmid transfection is a common approach in studies in cultured mammalian cells. To examine behavior of transfected plasmids, we analyzed their…”
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Aurora kinase A is not involved in CPEB1 phosphorylation and cyclin B1 mRNA polyadenylation during meiotic maturation of porcine oocytes by Komrskova, Pavla, Susor, Andrej, Malik, Radek, Prochazkova, Barbora, Liskova, Lucie, Supolikova, Jaroslava, Hladky, Stepan, Kubelka, Michal

“…Regulation of mRNA translation by cytoplasmic polyadenylation is known to be important for oocyte maturation and further development. This process is generally…”
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Role of Cnot6l in maternal mRNA turnover by Horvat, Filip, Fulka, Helena, Jankele, Radek, Malik, Radek, Jun, Ma, Solcova, Katerina, Sedlacek, Radislav, Vlahovicek, Kristian, Schultz, Richard M, Svoboda, Petr

“…Removal of poly(A) tail is an important mechanism controlling eukaryotic mRNA turnover. The major eukaryotic deadenylase complex CCR4-NOT contains two…”
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Cell-Based Reporter System for High-Throughput Screening of MicroRNA Pathway Inhibitors and Its Limitations by Brustikova, Katerina, Sedlak, David, Kubikova, Jana, Skuta, Ctibor, Solcova, Katerina, Malik, Radek, Bartunek, Petr, Svoboda, Petr

“…MicroRNAs (miRNAs) are small RNAs repressing gene expression. They contribute to many physiological processes and pathologies. Consequently, strategies for…”
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RNA regulation and cancer development by Scholzová, Eva, Malík, Radek, Ševčík, Jan, Kleibl, Zdeněk

“…Abstract Cancer is viewed as a genetic disease. According to the currently accepted model of carcinogenesis, several consequential mutations in oncogenes or…”
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Shortcomings of short hairpin RNA-based transgenic RNA interference in mouse oocytes by Sarnova, Lenka, Malik, Radek, Sedlacek, Radislav, Svoboda, Petr

“…RNA interference (RNAi) is a powerful approach to study a gene function. Transgenic RNAi is an adaptation of this approach where suppression of a specific gene…”
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CRISPR-Induced Expression of N-Terminally Truncated Dicer in Mouse Cells by Malik, Radek, Svoboda, Petr

“…RNA interference (RNAi) designates sequence-specific mRNA degradation mediated by small RNAs generated from long double-stranded RNA (dsRNA) by RNase III…”
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