Search Results - "Malik, Indranil"

Molecular mechanisms underlying nucleotide repeat expansion disorders by Malik, Indranil, Kelley, Chase P., Wang, Eric T., Todd, Peter K.

“…The human genome contains over one million short tandem repeats. Expansion of a subset of these repeat tracts underlies over fifty human disorders, including…”
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Non-canonical initiation factors modulate repeat-associated non-AUG translation by Green, Katelyn M, Miller, Shannon L, Malik, Indranil, Todd, Peter K

“…Abstract Repeat-associated non-AUG (RAN) translation of expanded repeat-mutation mRNA produces toxic peptides in neurons of patients suffering from…”
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Author Correction: Molecular mechanisms underlying nucleotide repeat expansion disorders by Malik, Indranil, Kelley, Chase P., Wang, Eric T., Todd, Peter K.

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Organismal benefits of transcription speed control at gene boundaries by Leng, Xueyuan, Ivanov, Maxim, Kindgren, Peter, Malik, Indranil, Thieffry, Axel, Brodersen, Peter, Sandelin, Albin, Kaplan, Craig D, Marquardt, Sebastian

“…RNA polymerase II (RNAPII) transcription is crucial for gene expression. RNAPII density peaks at gene boundaries, associating these key regions for gene…”
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Dissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGG repeat-associated toxicity in a Drosophila model of FXTAS by Malik, Indranil, Tseng, Yi-Ju, Wieland, Clare M., Green, Katelyn M., Zheng, Kristina, Calleja, Katyanne, Todd, Peter K.

“…Neurodegeneration in Fragile X-associated tremor/ataxia syndrome (FXTAS) is caused by a CGG trinucleotide repeat expansion in the 5′ UTR of FMR1. Expanded CGG…”
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SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity by Malik, Indranil, Tseng, Yi‐Ju, Wright, Shannon E, Zheng, Kristina, Ramaiyer, Prithika, Green, Katelyn M, Todd, Peter K

“…Transcribed CGG repeat expansions cause neurodegeneration in Fragile X‐associated tremor/ataxia syndrome (FXTAS). CGG repeat RNAs sequester RNA‐binding…”
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Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble by Barnes, Christopher O., Calero, Monica, Malik, Indranil, Graham, Brian W., Spahr, Henrik, Lin, Guowu, Cohen, Aina E., Brown, Ian S., Zhang, Qiangmin, Pullara, Filippo, Trakselis, Michael A., Kaplan, Craig D., Calero, Guillermo

“…Notwithstanding numerous published structures of RNA Polymerase II (Pol II), structural details of Pol II engaging a complete nucleic acid scaffold have been…”
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Universal promoter scanning by Pol II during transcription initiation in Saccharomyces cerevisiae by Qiu, Chenxi, Jin, Huiyan, Vvedenskaya, Irina, Llenas, Jordi Abante, Zhao, Tingting, Malik, Indranil, Visbisky, Alex M, Schwartz, Scott L, Cui, Ping, Čabart, Pavel, Han, Kang Hoo, Lai, William K M, Metz, Richard P, Johnson, Charles D, Sze, Sing-Hoi, Pugh, B Franklin, Nickels, Bryce E, Kaplan, Craig D

“…The majority of eukaryotic promoters utilize multiple transcription start sites (TSSs). How multiple TSSs are specified at individual promoters across…”
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One-Pot Multicomponent Synthesis of Diversely Substituted 2-Aminopyrroles. A Short General Synthesis of Rigidins A, B, C, and D by Frolova, Liliya V, Evdokimov, Nikolai M, Hayden, Kathryn, Malik, Indranil, Rogelj, Snezna, Kornienko, Alexander, Magedov, Igor V

“…Privileged medicinal scaffolds based on the structures of tetra- and pentasubstituted 2-aminopyrroles were prepared via one-pot multicomponent reactions of…”
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Dissecting the role of GGGGCC repeat RNA secondary structure in cellular toxicity associated with C9 FTD/ALS by Malik, Indranil

“…Background Aberrant expansions of simple nucleotide repeat sequences can cause more than fifty human diseases. For example, the most common genetic cause of…”
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Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine by Hoose, Scott A, Duran, Camille, Malik, Indranil, Eslamfam, Shabnam, Shasserre, Samantha C, Downing, S Sabina, Hoover, Evelyn M, Dowd, Katherine E, Smith, 3rd, Roger, Polymenis, Michael

“…Screening chemical libraries to identify compounds that affect overall cell proliferation is common. However, in most cases, it is not known whether the…”
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"Deoxy" to be or "Desoxy" not to be-a century-old tale in the history of DNA nomenclature by Sharma, Gaurav, Chodvadiya, Jaimin, Malik, Indranil

“…This commentary discusses a comprehensive history of the first-ever use of pertinent words directly related to DNA, such as desoxyribose, deoxyribose,…”
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Repeat RNA structure and protein interactions influence RAN translation and neurodegenerative phenotypes in models of FTD and ALS by Malik, Indranil, Swaminathan, Harish, Rouskin, Silvi, Todd, Peter K.

“…Background The most common genetic cause of Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) is an intronic GGGGCC hexanucleotide repeat…”
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Thiolutin has complex effects in vivo but is a direct inhibitor of RNA polymerase II in vitro by Qiu, Chenxi, Arora, Payal, Malik, Indranil, Laperuta, Amber J, Pavlovic, Emily M, Ugochukwu, Scott, Naik, Mandar, Kaplan, Craig D

“…Abstract Thiolutin is a natural product transcription inhibitor with an unresolved mode of action. Thiolutin and the related dithiolopyrrolone holomycin…”
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Wide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo by Malik, Indranil, Qiu, Chenxi, Snavely, Thomas, Kaplan, Craig D

“…Here we employ a set of RNA Polymerase II (Pol II) activity mutants to determine the consequences of increased or decreased Pol II catalysis on gene expression…”
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Multicomponent synthesis of 2,3-dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: a novel heterocyclic scaffold with antibacterial activity by Frolova, Liliya V., Malik, Indranil, Uglinskii, Pavel Y., Rogelj, Snezna, Kornienko, Alexander, Magedov, Igor V.

“…A multicomponent reaction of 3-aminopyrazol-5-ones with substituted salicylic aldehydes and acetylacetic ester leading to the formation of novel…”
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Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats by Tseng, Yi-Ju, Krans, Amy, Malik, Indranil, Deng, Xiexiong, Yildirim, Evrim, Ovunc, Sinem, Tank, Elizabeth M H, Jansen-West, Karen, Kaufhold, Ross, Gomez, Nicolas B, Sher, Roger, Petrucelli, Leonard, Barmada, Sami J, Todd, Peter K

“…A GGGGCC (G4C2) hexanucleotide repeat expansion in C9ORF72 causes amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD), while a CGG…”
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Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome by Kong, Ha Eun, Lim, Junghwa, Linsalata, Alexander, Kang, Yunhee, Malik, Indranil, Allen, Emily G, Cao, Yiqu, Shubeck, Lisa, Johnston, Rich, Huang, Yanting, Gu, Yanghong, Guo, Xiangxue, Zwick, Michael E, Qin, Zhaohui, Wingo, Thomas S, Juncos, Jorge, Nelson, David L, Epstein, Michael P, Cutler, David J, Todd, Peter K, Sherman, Stephanie L, Warren, Stephen T, Jin, Peng

“…Fragile X–associated tremor/ataxia syndrome (FXTAS) is a debilitating late-onset neurodegenerative disease in premutation carriers of the expanded CGG repeat…”
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In Vivo Consequences of Altered Pol II Catalysis by Malik, Indranil

“…Gene transcription by RNA polymerase II (Pol II) is an essential process. Using Saccharomyces cerevisiae as a model system, our lab has previously identified…”
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Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2,3-disubstituted indoles and their antimicrobial activity by Daly, Seth, Hayden, Kathryn, Malik, Indranil, Porch, Nikki, Tang, Hong, Rogelj, Snezna, Frolova, Liliya V., Lepthien, Katrina, Kornienko, Alexander, Magedov, Igor V.

“…A novel reaction of indole with aryldiazonium salts leading to the formation of 2-aryl-3-(arylazo)indoles was discovered. The products were found to possess…”
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