Search Results - "Malik, Hassan Z."

Inflammation and cancer: What a surgical oncologist should know by Dupré, Aurélien, Malik, Hassan Z.

“…Chronic inflammation is an aberrantly prolonged form of a protective response to a loss of tissue homeostasis and it is involved in several steps of the…”
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Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2 by Olayanju, Adedamola, Copple, Ian M., Bryan, Holly K., Edge, George T., Sison, Rowena L., Wong, Min Wei, Lai, Zheng-Quan, Lin, Zhi-Xiu, Dunn, Karen, Sanderson, Christopher M., Alghanem, Ahmad F., Cross, Michael J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Malik, Hassan Z., Kitteringham, Neil R., Goldring, Christopher E., Park, B. Kevin

“…The transcription factor Nrf2 regulates the basal and inducible expression of a battery of cytoprotective genes. Whereas numerous Nrf2-inducing small molecules…”
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Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile by Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.

“…The application of primary human hepatocytes following isolation from human tissue is well accepted to be compromised by the process of dedifferentiation. This…”
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Curative-intent treatment of recurrent colorectal liver metastases: A comparison between ablation and resection by Dupré, Aurélien, Jones, Robert P., Diaz-Nieto, Rafael, Fenwick, Stephen W., Poston, Graeme J., Malik, Hassan Z.

“…Liver-limited recurrence after resection of colorectal liver metastases is a frequent occurrence, and can in some cases be treated with curative intent…”
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Defined criteria for resectability improves rates of secondary resection after systemic therapy for liver limited metastatic colorectal cancer by Jones, Robert P, Hamann, Susanne, Malik, Hassan Z, Fenwick, Stephen W, Poston, Graeme J, Folprecht, Gunnar

“…Abstract Aims Long-term survival has been demonstrated for patients with irresectable colorectal liver metastases who are brought to resection by chemotherapy…”
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Preoperative prognostic score for predicting survival after hepatic resection for colorectal liver metastases by MALIK, Hassan Z, RAJENDRA PRASAD, K, HALAZUN, Karim J, ALDOORI, Amir, AL-MUKHTAR, Ahmed, GOMEZ, Dhanwant, PETER, J, LODGE, A, TOOGOOD, Giles J

“…Despite indications for resection of colorectal liver metastases having expanded, debate continues about identifying patients that may benefit from surgery…”
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From mice to men: Murine models of colorectal cancer for use in translational research by Evans, Jonathan P, Sutton, Paul A, Winiarski, Boleslaw K, Fenwick, Stephen W, Malik, Hassan Z, Vimalachandran, Dale, Tweedle, Elizabeth M, Costello, Eithne, Palmer, Daniel H, Park, B. Kevin, Kitteringham, Neil R

“…Abstract Colorectal cancer (CRC) is the third most common carcinoma worldwide and despite advances in treatment, survival for patients with metastatic disease…”
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Colorectal Liver Metastases: A Critical Review of State of the Art by Jones, Robert P, Kokudo, Norihiro, Folprecht, Gunnar, Mise, Yoshihiro, Unno, Michiaki, Malik, Hassan Z, Fenwick, Stephen W, Poston, Graeme J

“…Background: Over 50% of patients with colorectal cancer will develop liver metastases. Only a minority of patients present with technically resectable disease…”
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Evolution of surgical microwave ablation for the treatment of colorectal cancer liver metastasis: review of the literature and a single centre experience by Stättner, Stefan, Primavesi, Florian, Yip, Vincent S., Jones, Robert P., Öfner, Dietmar, Malik, Hassan Z., Fenwick, Stephen W., Poston, Graeme J.

“…Surgical resection is the gold standard treatment for colorectal liver metastasis, with reported five-year survival rates of 40 %. Unfortunately, despite…”
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Stage IV colorectal cancer: Outcomes following the liver-first approach by de Rosa, Antonella, Gomez, Dhanwant, Hossaini, Sina, Duke, Katie, Fenwick, Stephen W., Brooks, Adam, Poston, Graema J., Malik, Hassan Z., Cameron, Iain C.

“…Background To date, there is limited data on the liver‐first approach in the management of colorectal liver metastases (CRLM). The aim of the study was to…”
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50th Anniversary Presidential Edition - Hassan Z Malik by Malik, Fatima, Malik, Hassan Z.

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Long-Term Outcomes and Exploratory Analyses of the Randomized Phase III BILCAP Study by Bridgewater, John, Fletcher, Peter, Palmer, Daniel H, Malik, Hassan Z, Prasad, Raj, Mirza, Darius, Anthony, Alan, Corrie, Pippa, Falk, Stephen, Finch-Jones, Meg, Wasan, Harpreet, Ross, Paul, Wall, Lucy, Wadsley, Jonathan, Evans, Thomas R, Stocken, Deborah, Stubbs, Clive, Praseedom, Raaj, Ma, Yuk Ting, Davidson, Brian, Neoptolemos, John, Iveson, Tim, Cunningham, David, Garden, O James, Valle, Juan W, Primrose, John

“…The BILCAP study described a modest benefit for capecitabine as adjuvant therapy for curatively resected biliary tract cancer (BTC), and capecitabine has…”
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Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study by Primrose, John N, Fox, Richard P, Palmer, Daniel H, Malik, Hassan Z, Prasad, Raj, Mirza, Darius, Anthony, Alan, Corrie, Pippa, Falk, Stephen, Finch-Jones, Meg, Wasan, Harpreet, Ross, Paul, Wall, Lucy, Wadsley, Jonathan, Evans, Jeff T R, Stocken, Deborah, Praseedom, Raaj, Ma, Yuk Ting, Davidson, Brian, Neoptolemos, John P, Iveson, Tim, Raftery, James, Zhu, Shihua, Cunningham, David, Garden, O James, Stubbs, Clive, Valle, Juan W, Bridgewater, John, Primrose, JN, Fox, RP, Morement, H, Chan, O, Rees, C, Ma, YT, Hickish, T, Falk, S, Finch-Jones, M, Pope, I, Corrie, P, Crosby, T, Sothi, S, Sharkland, K, Adamson, D, Wall, L, Evans, J, Dent, J, Hombaiah, U, Iwuji, C, Anthoney, A, Bridgewater, J, Cunningham, D, Gillmore, R, Ross, P, Slater, S, Wasan, H, Waters, J, Valle, JW, Palmer, D, Malik, H, Neoptolemos, J, Faluyi, O, Sumpter, K, Dernedde, U, Maduhusudan, S, Cogill, G, Archer, C, Iveson, T, Wadsley, J, Darby, S, Peterson, M, Mukhtar, AA, Thorpe, JG, Bateman, A, Tsang, D, Cummins, S, Nolan, L, Beaumont, E, Prasad, R, Mirza, D, Stocken, D, Praseedom, R, Davidson, B, Raftery, J, Zhu, S, Garden, J, Stubbs, C, Coxon, F

“…Despite improvements in multidisciplinary management, patients with biliary tract cancer have a poor outcome. Only 20% of patients are eligible for surgical…”
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Specific mutations in KRAS codon 12 are associated with worse overall survival in patients with advanced and recurrent colorectal cancer by Jones, Robert P, Sutton, Paul A, Evans, Jonathan P, Clifford, Rachel, McAvoy, Andrew, Lewis, James, Rousseau, Abigail, Mountford, Roger, McWhirter, Derek, Malik, Hassan Z

“…Background: Activating mutations in KRAS have been suggested as potential predictive and prognostic biomarkers. However, the prognostic impact of specific…”
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Hepatic steatosis, body mass index and long term outcome in patients undergoing hepatectomy for colorectal liver metastases by Pathak, S, Tang, J.M.F, Terlizzo, M, Poston, G.J, Malik, Hassan Z

“…Abstract Background Hepatic steatosis (HS) is as an independent risk factor for morbidity and mortality post-hepatectomy. Recent studies report significant…”
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Data driven decision-making for older patients with hepatocellular carcinoma by Shapey, Iestyn M., Malik, Hassan Z., de Liguori Carino, Nicola

“…Older age is a risk factor for the development of HCC. However, the treatment options available for older patients with HCC, their safety, efficacy and…”
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Large Hepatocellular Carcinoma: Time to Stop Preoperative Biopsy by Young, Alastair L., MRCS, Malik, Hassan Z., MD, FRCS, Abu-Hilal, Mohammed, MD, Guthrie, J. Ashley, MRCP, FRCR, Wyatt, Judy, MBChB, FRCPath, Prasad, K. Rajendra, MS, MCh, FRCS, Toogood, Giles J., DM, FRCS, Lodge, J. Peter A., MD, FRCS

“…Background In Western countries, hepatocellular carcinoma (HCC) often presents at a large size, which is seen as a contraindication to transplantation and…”
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Influence of the primary tumour location in patients undergoing surgery for colorectal liver metastases by Dupré, Aurélien, Malik, Hassan Z., Jones, Robert P., Diaz-Nieto, Rafael, Fenwick, Stephen W., Poston, Graeme J.

“…The prognosis of patients undergoing liver resection for colorectal liver metastases (CLM) seems to be altered when the primary tumour is right-sided. However,…”
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PINCER (A Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational research by Jones, Robert P, Mielgo, Ainhoa, Schmid, Michael, Bury, Danielle, Andrews, Timothy, Burdak-Rothkamm, Susanne, Shackcloth, Michael, J. S. Cross, Timothy, Fenwick, Stephen, Malik, Hassan Z, Diaz-Nieto, Rafa, Ottensmeier, Christian, Palmer, Daniel H, Vimalachandran, Dale

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Preoperative endoscopic biliary drainage by metal versus plastic stents for resectable perihilar cholangiocarcinoma by de Jong, David M., Gilbert, Timothy M., Nooijen, Lynn E., Braunwarth, Eva, Ninkovic, Marijana, Primavesi, Florian, Malik, Hassan Z., Stern, Nick, Sturgess, Richard, Erdmann, Joris I., Voermans, Rogier P., Bruno, Marco J., Koerkamp, Bas Groot, van Driel, Lydi M.J.W.

“…Adequate preoperative biliary drainage (PBD) is recommended in most patients with resectable perihilar cholangiocarcinoma (pCCA). Most expert centers use…”
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