Search Results - "Malik, Fayaz"

Purification and Characterization of Glutaminase Free Asparaginase from Enterobacter cloacae: In-Vitro Evaluation of Cytotoxic Potential against Human Myeloid Leukemia HL-60 Cells by Husain, Islam, Sharma, Anjana, Kumar, Suresh, Malik, Fayaz

“…Asparaginase is an important antileukemic agent extensively used worldwide but the intrinsic glutaminase activity of this enzymatic drug is responsible for…”
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Unveiling the mechanisms and challenges of cancer drug resistance by Khan, Sameer Ullah, Fatima, Kaneez, Aisha, Shariqa, Malik, Fayaz

“…Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer treatment strategies are evolving due to innate and acquired resistance…”
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Targeting redox regulation and autophagy systems in cancer stem cells by Khan, Sameer Ullah, Rayees, Sheikh, Sharma, Pankaj, Malik, Fayaz

“…Cancer is a dysregulated cellular level pathological condition that results in tumor formation followed by metastasis. In the heterogeneous tumor architecture,…”
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Purification and characterization of glutaminase free asparaginase from Pseudomonas otitidis: Induce apoptosis in human leukemia MOLT-4 cells by Husain, Islam, Sharma, Anjana, Kumar, Suresh, Malik, Fayaz

“…Asparaginase is an important antineoplastic drug extensively used for the treatment of acute lymphoblastic leukemia, but the intrinsic glutaminase activity of…”
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Neuroprotective activity of natural products isolated from Senecio graciliflorus DC against corticosterone-induced impairment in SH-SY5Y cells by Jameel, Salman, Kaur, Loveleena, Bhat, Showkat Ahmad, Malik, Fayaz A., Bhat, Khursheed Ahmad

“…Senecio graciliflorus DC root extract was studied for secondary metabolite composition following the bioactivity-guided isolation technique. The ethyl acetate…”
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Correction to: Neuroprotective activity of natural products isolated from Senecio graciliflorus DC against corticosterone‑induced impairment in SH‑SY5Y cells by Jameel, Salman, Kaur, Loveleena, Bhat, Showkat Ahmad, Malik, Fayaz A., Bhat, Khursheed Ahmad

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Sonogashira coupling-based synthesis and in vitro cytotoxic evaluation of C-2 alkynyl derivatives of withaferin A by Ahmad Mir, Shabir, Firdous, Sameera, Shahid Maqbool, Mir, Hussain, Gulzar, Yaqoob Bhat, Mohammad, Malik, Fayaz A., Khalid Yousuf, Syed

“…[Display omitted] •The Sonogashira reaction was explored to synthesize 2-alkynyl derivatives of Withaferin A.•Sixteen new analogs of withaferin A have been…”
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Lavender Plant: Farming and Health Benefits by Khan, Sameer Ullah, Hamza, Baseerat, Mir, Reyaz Hassan, Fatima, Kaneez, Malik, Fayaz

“…Natural remedies from a range of sources, including plants, animals, microorganisms, and marine life, have made a significant contribution to the treatment of…”
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Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population by Korkaya, Hasan, Kim, Gwang-il, Davis, April, Malik, Fayaz, Henry, N. Lynn, Ithimakin, Suthinee, Quraishi, Ahmed A., Tawakkol, Nader, D'Angelo, Rosemarie, Paulson, Amanda K., Chung, Susan, Luther, Tahra, Paholak, Hayley J., Liu, Suling, Hassan, Khaled A., Zen, Qin, Clouthier, Shawn G., Wicha, Max S.

“…Although inactivation of the PTEN gene has been implicated in the development of resistance to the HER2 targeting antibody trastuzumab, the mechanisms…”
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Activation of lysosomal mediated cell death in the course of autophagy by mTORC1 inhibitor by Khan, Sameer Ullah, Pathania, Anup Singh, Wani, Abubakar, Fatima, Kaneez, Mintoo, Mubashir Javed, Hamza, Baseerat, Paddar, Masroor Ahmad, Bhumika, Wadhwa, Anand, Loveleena Kour, Maqbool, Mir Shahid, Mir, Sameer Ahmad, Kour, Jaspreet, Venkateswarlu, Vunnam, Mondhe, Dilip Manikrao, Sawant, Sanghapal D., Malik, Fayaz

“…Lysosomal biogenesis plays a vital role in cell fate. Under certain conditions, excessive lysosomal biogenesis leads to susceptibility for lysosomal membrane…”
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TFA-mediated stereoselective aza-Michael addition for the synthesis of 3β-arylamine derivatives of withaferin A and evaluation of their anticancer potential by Mir, Shabir Ahmad, Wani, Rafiq Ahmad, Maqbool, Mir Shahid, Singh, Deepika, Bharitkar, Yogesh P., Malik, Fayaz A., Yousuf, Syed Khalid

“…[Display omitted] •TFA-mediated simple and efficient protocol for the aza-Michael addition of anilines along the ring A of withaferin A is developed.•A series…”
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Design, synthesis and neuroprotective evaluation of nitrogen heterocyclic and triazole derivatives of sarracinic acid by Jameel, Salman, Kaur, Loveleena, Amin, Henna, Bhat, Showkat Ahmad, Malik, Fayaz A., Bhat, Khursheed Ahmad

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2,4-Diarylpyrano[3,2-c]chromen-5(4H)-ones as Antiproliferative Agents: Design, Synthesis and Biological Evaluation by Kumar, Dinesh, Malik, Fayaz, Bedi, Preet Mohinder Singh, Jain, Subheet

“…In the present study, a series of 2,4-diarylpyrano[3,2-c]chromen-5(4H)-ones were synthesised and evaluated as antiproliferative agents. The compounds were…”
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HER2 Drives Luminal Breast Cancer Stem Cells in the Absence of HER2 Amplification: Implications for Efficacy of Adjuvant Trastuzumab by ITHIMAKIN, Suthinee, DAY, Kathleen C, HALL, Christopher L, PALANISAMY, Nallasivam, HEATH, Amber N, TAWAKKOL, Nader, LUTHER, Tahra K, CLOUTHIER, Shawn G, CHADWICK, Whitney A, DAY, Mark L, KLEER, Celina G, THOMAS, Dafydd G, MALIK, Fayaz, HAYES, Daniel F, KORKAYA, Hasan, WICHA, Max S, QIN ZEN, DAWSEY, Scott J, BERSANO-BEGEY, Tom F, QURAISHI, Ahmed A, IGNATOSKI, Kathleen Woods, DAIGNAULT, Stephanie, DAVIS, April

“…Although current breast cancer treatment guidelines limit the use of HER2-blocking agents to tumors with HER2 gene amplification, recent retrospective analyses…”
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Suzuki coupling-based synthesis and in vitro cytotoxic evaluation of C-2 aryl derivatives of Withaferin A by Ahmad Mir, Shabir, Shahid Maqbool, Mir, Hussain, Gulzar, Bharitkar, Yogesh P., Malik, Fayaz A., Khalid Yousuf, Syed

“…•A simple and efficient protocol for the α-halogenation of ring A of withaferin A followed by palladium-mediated coupling of 2-iodowithaferin A with boronic…”
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Author Correction: Activation of lysosomal mediated cell death in the course of autophagy by mTORC1 inhibitor by Khan, Sameer Ullah, Pathania, Anup Singh, Wani, Abubakar, Fatima, Kaneez, Mintoo, Mubashir Javed, Hamza, Baseerat, Paddar, Masroor Ahmad, Bhumika, Wadhwa, Anand, Loveleena Kour, Maqbool, Mir Shahid, Mir, Sameer Ahmad, Kour, Jaspreet, Venkateswarlu, Vunnam, Mondhe, Dilip Manikrao, Sawant, Sanghapal D., Malik, Fayaz

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Diapolic acid A–B from an endophytic fungus, Diaporthe terebinthifolii depicting antimicrobial and cytotoxic activity by Yedukondalu, Nalli, Arora, Palak, Wadhwa, Bhumika, Malik, Fayaz Ahmad, Vishwakarma, Ram A, Gupta, Vivek K, Riyaz-Ul-Hassan, Syed, Ali, Asif

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Isolation and characterisation of pharmaceutically versatile molecules from Rumex dentatus and evaluation of their cytotoxic activity against human cancer cell lines by Khaliq, Tahirah, Waseem, Malik A, Mir, Sameer A, Sultan, Phalisteen, Malik, Fayaz A, Hassan, Qazi Parvaiz

“…The disclosed study reveals isolation, characterization and anticancer evaluation of . The extracts and isolated compounds were used for cytotoxic activity…”
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Combining ligand- and structure-based in silico methods for the identification of natural product-based inhibitors of Akt1 by Mahajan, Priya, Wadhwa, Bhumika, Barik, Manas Ranjan, Malik, Fayaz, Nargotra, Amit

“…The traditional method of drug discovery process has been surpassed by a rational approach where computer-aided drug designing plays a vital role in the…”
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14-Residue peptaibol velutibol A from Trichoderma velutinum : its structural and cytotoxic evaluation by Singh, Varun Pratap, Pathania, Anup Singh, Kushwaha, Manoj, Singh, Samsher, Sharma, Vandana, Malik, Fayaz A, Khan, Inshad A, Kumar, Anil, Singh, Deepika, Vishwakarma, Ram A

“…Velutibol A (1), a new 14-residue peptaibol was isolated from the Himalayan cold habitat fungus . The structural characterization was carried out by 1D and 2D…”
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