Search Results - "Malik, Chanchal K."

Novel genomic island modifies DNA with 7-deazaguanine derivatives by Thiaville, Jennifer J., Kellner, Stefanie M., Yuan, Yifeng, Hutinet, Geoffrey, Thiaville, Patrick C., Jumpathong, Watthanachai, Mohapatra, Susovan, Brochier-Armanet, Celine, Letarov, Andrey V., Hillebrand, Roman, Malik, Chanchal K., Rizzo, Carmelo J., Dedon, Peter C., de Crécy-Lagard, Valérie

“…The discovery of ∼20-kb gene clusters containing a family of paralogs of tRNA guanosine transglycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine…”
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Mutational Analysis of the C8-Guanine Adduct of the Environmental Carcinogen 3‑Nitrobenzanthrone in Human Cells: Critical Roles of DNA Polymerases η and κ and Rev1 in Error-Prone Translesion Synthesis by Pande, Paritosh, Malik, Chanchal K, Bose, Arindam, Jasti, Vijay P, Basu, Ashis K

“…3-Nitrobenzanthrone (3-NBA), a potent mutagen and suspected human carcinogen, is a common environmental pollutant. The genotoxicity of 3-NBA has been…”
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Domino Metathesis Involving ROM-RCM of Substituted Norbornenes. Rapid Access to Densely Functionalized Tricyclic Bridged and Condensed Ring Systems by Malik, Chanchal K, Ghosh, Subrata

“…Domino metathesis involving ROM-RCM of appropriately constructed norbornene derivatives having multiple alkene chains leads to direct access of highly…”
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Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y‑Family DNA Polymerase by Vyas, Rajan, Efthimiopoulos, Georgia, Tokarsky, E. John, Malik, Chanchal K, Basu, Ashis K, Suo, Zucai

“…1-Nitropyrene (1-NP), an environmental pollutant, induces DNA damage in vivo and is considered to be carcinogenic. The DNA adducts formed by the 1-NP…”
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Base-Displaced Intercalated Structure of the N‑(2′-Deoxyguanosin-8-yl)-3-aminobenzanthrone DNA Adduct by Politica, Dustin A, Malik, Chanchal K, Basu, Ashis K, Stone, Michael P

“…3-Nitrobenzanthrone (3-NBA), an environmental mutagen found in diesel exhaust and a suspected carcinogen, undergoes metabolic reduction followed by reaction…”
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Configurational and Conformational Equilibria of N 6‑(2-Deoxy‑d‑erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5‑N‑methylformamidopyrimidine (MeFapy-dG) Lesion in DNA by Bamberger, Stephanie N, Malik, Chanchal K, Voehler, Markus W, Brown, Summer K, Pan, Hope, Johnson-Salyard, Tracy L, Rizzo, Carmelo J, Stone, Michael P

“…The most common lesion in DNA occurring due to clinical treatment with Temozolomide or cellular exposures to other methylating agents is 7-methylguanine…”
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Mechanistic investigation of the bypass of a bulky aromatic DNA adduct catalyzed by a Y-family DNA polymerase by Gadkari, Varun V., Tokarsky, E. John, Malik, Chanchal K., Basu, Ashis K., Suo, Zucai

“…•3-Nitrobenzanthrone is one of the most mutagenic compounds from diesel exhaust.•Pre-steady-state kinetic analysis of DNA damage bypass.•A mechanism of lesion…”
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Pre-steady-state kinetic investigation of bypass of a bulky guanine lesion by human Y-family DNA polymerases by Tokarsky, E. John, Gadkari, Varun V., Zahurancik, Walter J., Malik, Chanchal K., Basu, Ashis K., Suo, Zucai

“…[Display omitted] •hPolη and hPolκ efficiently bypassed a site-specifically placed dGC8-N-ABA lesion.•The fidelity of hPolη decreased during dGC8-N-ABA bypass…”
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Configurational and Conformational Equilibria of N6-(2-Deoxy-d-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy-dG) Lesion in DNA by Bamberger, Stephanie N., Malik, Chanchal K., Voehler, Markus W., Brown, Summer K., Pan, Hope, Johnson-Salyard, Tracy L., Rizzo, Carmelo J., Stone, Michael P.

“…The most common lesion in DNA occurring due to clinical treatment with Temozolomide or cellular exposures to other methylating agents is 7-methylguanine…”
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Structural Basis for Error-Free Bypass of the 5‑N‑Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase η and Sulfolobus solfataricus P2 Polymerase IV by Patra, Amritraj, Banerjee, Surajit, Johnson Salyard, Tracy L, Malik, Chanchal K, Christov, Plamen P, Rizzo, Carmelo J, Stone, Michael P, Egli, Martin

“…N 6-(2-Deoxy-d-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy-dG) arises from N7-methylation of deoxyguanosine…”
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Error‐prone replication bypass of the imidazole ring‐opened formamidopyrimidine deoxyguanosine adduct by Sha, Yan, Minko, Irina G., Malik, Chanchal K., Rizzo, Carmelo J., Lloyd, R. Stephen, Wilson, David M.

“…Addition of hydroxyl radicals to the C8 position of 2′‐deoxyguanosine generates an 8‐hydroxyguanyl radical that can be converted into either…”
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Kinetic Analysis of the Bypass of a Bulky DNA Lesion Catalyzed by Human Y-Family DNA Polymerases by Sherrer, Shanen M, Sanman, Laura E, Xia, Cynthia X, Bolin, Eric R, Malik, Chanchal K, Efthimiopoulos, Georgia, Basu, Ashis K, Suo, Zucai

“…1-Nitropyrene (1-NP), a mutagen and potential carcinogen, is the most abundant nitro polyaromatic hydrocarbon in diesel exhaust, which reacts with DNA to form…”
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Synthesis of Oligodeoxynucleotides Containing a C8-2'-Deoxyguanosine Adduct Formed by the Carcinogen 3-Nitrobenzanthrone by Chatterjee, Arindom, Malik, Chanchal K, Basu, Ashis K

“…This unit describes the detailed procedure in five parts for the synthesis of the C8-2'-deoxyguanosine-3-aminobenzanthrone adduct located in a desired site in…”
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Synthesis of Fused Cyclic Systems Containing Medium-Sized Rings through Tandem ROM-RCM of Norbornene Derivatives Embedded in a Carbohydrate Template by Malik, Chanchal K, Yadav, Ram Naresh, Drew, Michael G. B, Ghosh, Subrata

“…A general approach for the synthesis of fused cyclic systems containing medium-sized rings (7−9) has been developed. The key steps involve a…”
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Effect of ring fusion stereochemistry on double bond geometry. Unexpected formation of nine-membered cyclic ether with E-configurated double bond through RCM by Ghosh, Subrata, Hossain, Md. Firoj, Malik, Chanchal K., Maity, Soumitra

“…Formation of a nine-membered cyclic ether with E-configurated double bond was observed during construction of 5-9-5 tricycles through RCM of dienes. Ring…”
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Synthesis of [1,3, NH2-15N3] (5′S)-8,5′-cyclo-2′-deoxyguanosine by Malik, Chanchal K., Das, Rajat S., Basu, Ashis K.

“…To facilitate NMR studies and low‐level detection in biological samples by mass spectrometry, [1,3, NH2‐15N3] (5′S)‐8,5′‐cyclo‐2′‐deoxyguanosine was…”
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A novel asymmetric approach to a densely functionalized lactarane ring system through a domino ring opening–ring closing metathesis of a norbornene derivative by Mondal, Sujit, Malik, Chanchal K., Ghosh, Subrata

“…A novel route for the synthesis of a highly functionalized lactarane skeleton in enantiomerically pure form is described via ROM–RCM of an appropriately…”
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Expedient route to CDE ring system of schintrilactones through tandem ROM–RCM of a norbornene derivative by Matcha, Kiran, Maity, Soumitra, Malik, Chanchal K., Ghosh, Subrata

“…A concise synthesis of a highly functionalized tricyclic ring system representing the CDE core of nortriterpenoid schintrilactones A and B is described using a…”
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Quantitative analysis of the mutagenic potential of 1-aminopyrene-DNA adduct bypass catalyzed by Y-family DNA polymerases by Sherrer, Shanen M, Taggart, David J, Pack, Lindsey R, Malik, Chanchal K, Basu, Ashis K, Suo, Zucai

“…N-(Deoxyguanosin-8-yl)-1-aminopyrene (dG(AP)) is the predominant nitro polyaromatic hydrocarbon product generated from the air pollutant 1-nitropyrene reacting…”
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Structural Basis for Error-Free Bypass of the N7-Methyl-Formamidopyrimidine-dG Lesion by Human DNA Polymerase η and Sulfolobus solfataricus P2 Polymerase IV (Dpo4) by Patra, Amritraj, Banerjee, Surajit, Johnson Salyard, Tracy L., Malik, Chanchal K., Christov, Plamen P., Rizzo, Carmelo J., Stone, Michael P., Egli, Martin

“…2,6-Diamino-4-hydroxy-5N-methylformamidopyrimidine (MeFapy-dG) arises from N7-methylation of guanine followed by imidazole ring opening. The lesion has been…”
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