Search Results - "Malik, Amal I"

Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water by Moffat, Ivy, Chepelev, Nikolai L., Labib, Sarah, Bourdon-Lacombe, Julie, Kuo, Byron, Buick, Julie K., Lemieux, France, Williams, Andrew, Halappanavar, Sabina, Malik, Amal I, Luijten, Mirjam, Aubrecht, Jiri, Hyduke, Daniel R., Fornace, Albert J., Swartz, Carol D., Recio, Leslie, Yauk, Carole L.

“…Abstract Toxicogenomics is proposed to be a useful tool in human health risk assessment. However, a systematic comparison of traditional risk assessment…”
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Increased transcript levels and kinetic function of pyruvate kinase during severe dehydration in aestivating African clawed frogs, Xenopus laevis by Dawson, Neal J., Biggar, Yulia, Malik, Amal I., Storey, Kenneth B.

“…The African clawed frog, Xenopus laevis, can withstand extremely arid conditions through aestivation, resulting in dehydration and urea accumulation…”
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The regulation of heat shock proteins in response to dehydration in Xenopus laevis by Luu, Bryan E., Wijenayake, Sanoji, Malik, Amal I., Storey, Kenneth B.

“…African clawed frogs (Xenopus laevis) endure bouts of severe drought in their natural habitats and survive the loss of approximately 30% of total body water…”
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Integrating toxicogenomics into human health risk assessment: Lessons learned from the benzo[a]pyrene case study by Chepelev, Nikolai L., Moffat, Ivy D., Labib, Sarah, Bourdon-Lacombe, Julie, Kuo, Byron, Buick, Julie K., Lemieux, France, Malik, Amal I., Halappanavar, Sabina, Williams, Andrew, Yauk, Carole L.

“…Abstract The use of short-term toxicogenomic tests to predict cancer (or other health effects) offers considerable advantages relative to traditional toxicity…”
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Hepatic mRNA, microRNA, and miR-34a-Target responses in mice after 28 days exposure to doses of benzo(a)pyrene that elicit DNA damage and mutation by Malik, Amal I., Williams, Andrew, Lemieux, Christine L., White, Paul A., Yauk, Carole L.

“…Benzo(a)pyrene (BaP) is a mutagenic carcinogen that is ubiquitous in our environment. To better understand the toxic effects of BaP and to explore the…”
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Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene by Malik, Amal I, Rowan-Carroll, Andrea, Williams, Andrew, Lemieux, Christine L, Long, Alexandra S, Arlt, Volker M, Phillips, David H, White, Paul A, Yauk, Carole L

“…Dibenz[a,h]anthracene (DB[a,h]A) is a polycyclic aromatic hydrocarbon that is a by-product of combustion and a potent carcinogen. Few studies have investigated…”
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Hepatic genotoxicity and toxicogenomic responses in Muta super((TM))Mouse males treated with dibenz[a,h]anthracene by Malik, Amal I, Rowan-Carroll, Andrea, Williams, Andrew, Lemieux, Christine L, Long, Alexandra S, Arlt, Volker M, Phillips, David H, White, Paul A, Yauk, Carole L

“…Dibenz[a,h]anthracene (DB[a,h]A) is a polycyclic aromatic hydrocarbon that is a by-product of combustion and a potent carcinogen. Few studies have investigated…”
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