Search Results - "Malick, Waqas"
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Clinical Trial Design for Lipoprotein(a)-Lowering Therapies: JACC Focus Seminar 2/3
Published in Journal of the American College of Cardiology (25-04-2023)“…Lipoprotein(a) [Lp(a)] is a source of residual risk in patients with atherosclerotic cardiovascular disease (ASCVD). Clinical trials of fully human monoclonal…”
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Severe hypertriglyceridemia: Existing and emerging therapies
Published in Pharmacology & therapeutics (Oxford) (01-11-2023)“…Severe hypertriglyceridemia (sHTG), defined as a triglyceride (TG) concentration ≥ 500 mg/dL (≥ 5.7 mmol/L) is an important risk factor for acute pancreatitis…”
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Prediction of Venous Thromboembolism in Diverse Populations Using Machine Learning and Structured Electronic Health Records
Published in Arteriosclerosis, thrombosis, and vascular biology (01-02-2024)“…Venous thromboembolism (VTE) is a major cause of morbidity and mortality worldwide. Current risk assessment tools, such as the Caprini and Padua scores and…”
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Primary Prevention of Subclinical Atherosclerosis in Young Adults: JACC Review Topic of the Week
Published in Journal of the American College of Cardiology (28-11-2023)“…There is growing evidence that the atherosclerotic process that leads to symptomatic cardiovascular disease (CVD) starts at an early age. In young adults,…”
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Familial Hypercholesterolemia: Challenges for a High-Risk Population: JACC Focus Seminar 1/3
Published in Journal of the American College of Cardiology (25-04-2023)“…The availability of statins, ezetimibe, and PCSK9 inhibitors has significantly improved the prognosis of familial hypercholesterolemia (FH). However, a great…”
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Clinical Trial Design for Triglyceride-Rich Lipoprotein-Lowering Therapies: JACC Focus Seminar 3/3
Published in Journal of the American College of Cardiology (25-04-2023)“…Triglyceride-rich lipoproteins (TRLs) are a source of residual risk in patients with atherosclerotic cardiovascular disease, and are indirectly correlated with…”
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Long-term outcomes after Roux-en-Y gastric bypass: 10- to 13-year data
Published in Surgery for obesity and related diseases (01-01-2016)“…Abstract Background Short- and mid-term data on Roux-en-Y gastric bypass (RYGB) indicate sustained weight loss and improvement in co-morbidities. Few long-term…”
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Sex-Based Differences in Revascularization Outcomes: Is It Time for a Dedicated Randomized Trial in Women?
Published in Journal of the American Heart Association (01-03-2022)Get full text
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Exome sequence analysis identifies rare coding variants associated with a machine learning-based marker for coronary artery disease
Published in Nature genetics (01-07-2024)“…Coronary artery disease (CAD) exists on a spectrum of disease represented by a combination of risk factors and pathogenic processes. An in silico score for CAD…”
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ABCA1 Deficiency: A Rare Cause of Premature Coronary Artery Disease
Published in JACC. Case reports (19-07-2023)“…ATP-binding cassette transporter A1 (ABCA1) deficiency results in very low high-density lipoprotein cholesterol levels. Complete ABCA1 deficiency, or Tangier…”
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Predictors of Survival for Patients with Acute Decompensated Heart Failure Requiring Extra-Corporeal Membrane Oxygenation Therapy
Published in ASAIO journal (1992) (01-11-2019)“…Chronic systolic heart failure (HF) with acute decompensation can result in cardiogenic shock (CS) requiring short-term mechanical circulatory support. We…”
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Weight loss outcomes among patients referred after primary bariatric procedure
Published in The American journal of surgery (01-07-2016)“…Abstract Background Bariatric patients may not always obtain long-term care by their primary surgeon. Our aim was to evaluate weight loss outcomes in patients…”
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Diagnostic Value of Coronary Artery Calcium Scoring in Low-Intermediate Risk Patients Evaluated in the Emergency Department for Acute Coronary Syndrome
Published in The American journal of cardiology (2011)“…Early and accurate triage of patients with possible ischemic chest pain remains challenging in the emergency department because current risk stratification…”
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Abstract 17162: High Lp(a) is Associated With Activation of the Arachidonic Acid Pathway
Published in Circulation (New York, N.Y.) (07-11-2023)“…Abstract only Introduction: High lipoprotein(a) [Lp(a)] is associated with increased platelet aggregation, inflammation and cardiovascular events. Eicosanoids…”
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Familial Hypercholesterolemia: Challenges for a High-Risk Population
Published in Journal of the American College of Cardiology (25-04-2023)“…The availability of statins, ezetimibe, and PCSK9 inhibitors has significantly improved the prognosis of familial hypercholesterolemia (FH). However, a great…”
Get full text
Journal Article -
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Clinical Trial Design for Lipoprotein(a)-Lowering Therapies
Published in Journal of the American College of Cardiology (25-04-2023)“…Lipoprotein(a) [Lp(a)] is a source of residual risk in patients with atherosclerotic cardiovascular disease (ASCVD). Clinical trials of fully human monoclonal…”
Get full text
Journal Article -
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Abstract 4119535: Aspirin Use and Cardiovascular Disease Incidence in Adults with High Lipoprotein(a): A Multi-Cohort Study
Published in Circulation (New York, N.Y.) (12-11-2024)“…Abstract only Introduction: There is an active debate about who may benefit from taking aspirin to reduce their incidence of cardiovascular disease (CVD). Some…”
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Characterization of Myocardial Injury in Patients With COVID-19
Published in Journal of the American College of Cardiology (03-11-2020)“…BACKGROUNDMyocardial injury is frequent among patients hospitalized with coronavirus disease-2019 (COVID-19) and is associated with a poor prognosis. However,…”
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Abstract 18686: Distinct Proteomic Signatures in Subjects With Elevated Lipoprotein(a) Levels With and Without Coronary Artery Disease
Published in Circulation (New York, N.Y.) (07-11-2023)“…Abstract only Introduction: Genetic and observational studies suggest a causal link between an elevated lipoprotein(a) [Lp(a)] and coronary artery disease…”
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Clinical Trial Design for Triglyceride-Rich Lipoprotein-Lowering Therapies
Published in Journal of the American College of Cardiology (25-04-2023)“…Triglyceride-rich lipoproteins (TRLs) are a source of residual risk in patients with atherosclerotic cardiovascular disease, and are indirectly correlated with…”
Get full text
Journal Article