19F-nanoparticles: Platform for in vivo delivery of fluorinated biomaterials for 19F-MRI

Fluorine-19 (19F) magnetic resonance imaging (MRI) features one of the most investigated and innovative techniques for quantitative and unambiguous cell tracking, providing information for both localization and number of cells. Because of the relative insensitivity of the MRI technique, a high numbe...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of controlled release Vol. 338; pp. 870 - 889
Main Authors:	Mali, Alvja, Kaijzel, Eric L., Lamb, Hildo J., Cruz, Luis J.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 10-10-2021
Subjects:	19F magnetic resonance imaging Fluorine-19 Nanoparticles Nanoprobes Perfluocarbons Nanoparticles Fluorine-19 Nanoprobes 19F magnetic resonance imaging Perfluocarbons
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Fluorine-19 (19F) magnetic resonance imaging (MRI) features one of the most investigated and innovative techniques for quantitative and unambiguous cell tracking, providing information for both localization and number of cells. Because of the relative insensitivity of the MRI technique, a high number of magnetically equivalent fluorine atoms are required to gain detectable signals. However, an increased amount of 19F nuclei induces low solubility in aqueous solutions, making fluorine-based probes not suitable for in vivo imaging applications. In this context, nanoparticle-based platforms play a crucial role, since nanoparticles may carry a high payload of 19F-based contrast agents into the relevant cells or tissues, increase the imaging agents biocompatibility, and provide a highly versatile platform. In this review, we present an overview of the 19F-based nanoprobes for sensitive 19F-MRI, focusing on the main nanotechnologies employed to date, such as fluorine and theranostic nanovectors, including their design and applications. 19F-based Nanoprobes for fluorine-19 MRI purposes. [Display omitted] •Nanoparticles may carry a high payload of 19F-based contrast agents.•Perfluorocarbons-based nanoprobes are the most promising system.•Fluorinated biomaterial-based nanoprobes hold a high number of fluorine atoms.•19F- probes designed thus far show long T1 and short T2 relaxation times.•Perfluorocarbons-Paramagnetic nanoprobes shows an increased 19F imaging efficiency.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0168-3659 1873-4995
DOI:	10.1016/j.jconrel.2021.09.001