Search Results - "Maler, M."

Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer's disease patients and healthy controls by Kvartsberg, Hlin, Portelius, Erik, Andreasson, Ulf, Brinkmalm, Gunnar, Hellwig, Konstantin, Lelental, Natalia, Kornhuber, Johannes, Hansson, Oskar, Minthon, Lennart, Spitzer, Philipp, Maler, Juan M, Zetterberg, Henrik, Blennow, Kaj, Lewczuk, Piotr

“…Synaptic dysfunction and degeneration are central events in Alzheimer's disease (AD) pathophysiology that are thought to occur early in disease progression…”
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Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study by Lewczuk, P, Kamrowski-Kruck, H, Peters, O, Heuser, I, Jessen, F, Popp, J, Bürger, K, Hampel, H, Frölich, L, Wolf, S, Prinz, B, Jahn, H, Luckhaus, Ch, Perneczky, R, Hüll, M, Schröder, J, Kessler, H, Pantel, J, Gertz, H-J, Klafki, H-W, Kölsch, H, Reulbach, U, Esselmann, H, Maler, J M, Bibl, M, Kornhuber, J, Wiltfang, J

“…In this report, we present the results of a multicenter study to test analytic and diagnostic performance of soluble forms of amyloid precursor proteins α and…”
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A Specific Reduction in Aβ1−42 vs. a Universal Loss of Aβ Peptides in CSF Differentiates Alzheimer's Disease From Meningitis and Multiple Sclerosis by Spitzer, Philipp, Lang, Roland, Oberstein, Timo J., Lewczuk, Piotr, Ermann, Natalia, Huttner, Hagen B., Masouris, Ilias, Kornhuber, Johannes, Ködel, Uwe, Maler, Juan M.

“…A reduced concentration of Aβ1-42 in CSF is one of the established biomarkers of Alzheimer’s disease. Reduced CSF concentrations of Aβ1-42 have also been shown…”
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Highly conserved and disease‐specific patterns of carboxyterminally truncated Aβ peptides 1–37/38/39 in addition to 1–40/42 in Alzheimer's disease and in patients with chronic neuroinflammation by Wiltfang, J., Esselmann, H., Bibl, M., Smirnov, A., Otto, M., Paul, S., Schmidt, B., Klafki, H.‐W., Maler, M., Dyrks, T., Bienert, M., Beyermann, M., Rüther, E., Kornhuber, J.

“…Human lumbar CSF patterns of Aβ peptides were analysed by urea‐based β‐amyloid sodium dodecyl sulphate polyacrylamide gel electrophoresis with western…”
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Overview of veterinary chiropractic and its use in pediatric exotic patients by Maler, Marilyn M

“…The scope of this article will be an introduction to veterinary chiropractic and its use in treating pediatric exotic patients. After discussing the general…”
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ELEVATED HOMOCYSTEINE LEVELS IN ALCOHOL WITHDRAWAL by Bleich, S., Degner, D., Wiltfang, J., Maler, J. M., Niedmann, P., Cohrs, S., Mangholz, A., Porzig, J., Sprung, R., Rüther, E., Kornhuber, J.

“…Ethanol exerts its behavioural effects largely by interacting with receptors for brain neurotransmitters. However, the molecular mechanisms involving these…”
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Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels by KORNHUBER, J, BLEICH, S, WILTFANG, J, MALER, M, PARSONS, C. G

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Homocysteine induces cell death of rat astrocytes in vitro by Maler, J.M, Seifert, W, Hüther, G, Wiltfang, J, Rüther, E, Kornhuber, J, Bleich, S

“…From several disease states as well as from animal models homocysteine is known to be toxic to the central nervous system. Homocysteine is an excitatory amino…”
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Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG by Knopf, Jasmin, Magorivska, Iryna, Maler, Juan M., Spitzer, Philipp, Bilyy, Rostyslav, Biermann, Mona H.C., Hychka, Kateryna, Bondt, Albert, Wuhrer, Manfred, Toes, Rene E.M., Schett, Georg, Herrmann, Martin, Muñoz, Luis E.

“…Immunoglobulin G (IgG) harbors a conserved N-glycosylation site which is important for its effector functions. Changes in glycosylation of IgG occur in many…”
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Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's disease by Hellwig, Konstantin, Kvartsberg, Hlin, Portelius, Erik, Andreasson, Ulf, Oberstein, Timo Jan, Lewczuk, Piotr, Blennow, Kaj, Kornhuber, Johannes, Maler, Juan Manuel, Zetterberg, Henrik, Spitzer, Philipp

“…Neuroinflammation and synaptic degeneration are major neuropathological hallmarks in Alzheimer's disease (AD). Neurogranin and YKL-40 in cerebrospinal fluid…”
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CD133-Positive Membrane Particles in Cerebrospinal Fluid of Patients with Inflammatory and Degenerative Neurological Diseases by Bobinger, Tobias, May, Lisa, Lücking, Hannes, Kloska, Stephan P, Burkardt, Petra, Spitzer, Philipp, Maler, Juan M, Corbeil, Denis, Huttner, Hagen B

“…Analysis of cerebrospinal fluid (CSF) is a frequently used diagnostic tool in a variety of neurological diseases. Recent studies suggested that investigating…”
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Neurochemical diagnosis of Alzheimer's dementia by CSF A beta 42, A beta 42/A beta 40 ratio and total tau by Lewczuk, P, Esselmann, H, Otto, M, Maler, J M, Henkel, A W, Henkel, M K, Eikenberg, O, Antz, C, Krause, W-R, Reulbach, U, Kornhuber, J, Wiltfang, J

“…Cerebrospinal fluid (CSF) concentrations of amyloid beta peptides ending at positions 42 and 40 (A beta 42 and A beta 40, respectively), and total tau (tTau)…”
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Decreased circulating CD34 stem cells in early Alzheimer's disease: evidence for a deficient hematopoietic brain support? by Maler, J M, Spitzer, P, Lewczuk, P, Kornhuber, J, Herrmann, M, Wiltfang, J

“…Hematopoietic stem cells contribute to mammalian brain tissue regeneration by transdifferentiation processes. We found decreased counts of circulating CD34+…”
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Global panic reaction – A therapeutic approach to a world-wide economic crisis by Sperling, W, Biermann, T, Maler, J.M

“…Summary Drastic losses on the stock markets within short periods have been the subject of numerous investigations in view of the fact that they are often…”
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Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease: original data and review of the literature by Lewczuk, Piotr, Esselmann, Hermann, Bibl, Mirko, Beck, Georg, Maler, Juan Manuel, Otto, Markus, Kornhuber, Johannes, Wiltfang, Jens

“…Cerebrospinal fluid (CSF) concentrations of total Tau and Tau phosphorylated at threonine (position 181 [pTau181]) were studied with ELISA in a group of…”
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Antidepressant drugs modulate growth factors in cultured cells by Henkel, Andreas W, Sperling, Wolfgang, Rotter, Andrea, Reulbach, Udo, Reichardt, Cornelia, Bönsch, Dominikus, Maler, Juan M, Kornhuber, Johannes, Wiltfang, Jens

“…Different classes of antidepressant drugs are used as a treatment for depression by activating the catecholinergic system. In addition, depression has been…”
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Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer's disease by Lewczuk, Piotr, Ermann, Natalia, Andreasson, Ulf, Schultheis, Christian, Podhorna, Jana, Spitzer, Philipp, Maler, Juan Manuel, Kornhuber, Johannes, Blennow, Kaj, Zetterberg, Henrik

“…A growing body of evidence suggests that the plasma concentration of the neurofilament light chain (NfL) might be considered a plasma biomarker for the…”
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β-amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease by Wiltfang, Jens, Esselmann, Hermann, Smirnov, Alexander, Bibl, Mirko, Cepek, Lukas, Steinacker, Petra, Mollenhauer, Brit, Buerger, Katharina, Hampel, Harald, Paul, Sabine, Neumann, Manuela, Maler, Manuel, Zerr, Inga, Kornhuber, Johannes, Kretzschmar, Hans A., Poser, Sigrid, Otto, Markus

“…Decreased levels of β‐amyloid peptide 1‐42 (Aβ1‐42) in cerebrospinal fluid (CSF) are a characteristic feature of Alzheimer's disease (AD) but recently were…”
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Excitatory neurotransmission in alcoholism by Bleich, S, Sperling, W, Wiltfang, J, Maler, J M, Kornhuber, J

“…Glutamate is the neurotransmitter at the majority of excitatory synapses in the mammalian CNS. It has been proposed that neurotoxicity linked to chronic…”
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P.4.050 Homocysteine induces cell death of astrocytes in vitro by Maler, M., Wiltfang, J., Degner, D., Kornhuber, J., Bleich, S.

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