Search Results - "Malenka, R. C"

Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism by Jiang, M, Polepalli, J, Chen, L Y, Zhang, B, Südhof, T C, Malenka, R C

“…Neuroligins are postsynaptic cell-adhesion molecules implicated in autism and other neuropsychiatric disorders. Despite extensive work, the role of neuroligins…”
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Synaptic plasticity and dynamic modulation of the postsynaptic membrane by Lüscher, C, Nicoll, R. A, Malenka, R. C, Muller, D

“…The biochemical composition of the postsynaptic membrane and the structure of dendritic spines may be rapidly modulated by synaptic activity. Here we review…”
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Expression Mechanisms Underlying NMDA Receptor-Dependent Long-Term Potentiation by NICOLL, R. A., MALENKA, R. C.

“…Long‐term potentiation (LTP) is currently the best available cellular model for learning and memory in the mammalian brain. In the CA1 region of the…”
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Cocaine-Induced Potentiation of Synaptic Strength in Dopamine Neurons: Behavioral Correlates in GluRA(-/-) Mice by Dong, Y., Saal, D., Thomas, M., Faust, R., Bonci, A., Robinson, T., Malenka, R. C., Bloom, Floyd E.

“…Synaptic plasticity in the mesolimbic dopamine (DA) system is thought to contribute to the neural adaptations that mediate behavioral sensitization, a model…”
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Synaptic activation of kainate receptors on hippocampal interneurons by Nicoll, R. A, Frerking, M, Malenka, R. C

“…Although kainate receptor activation has been known to evoke epileptiform activity, little is known about the role of kainate receptors in synaptic…”
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Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens by NICOLA, S. M, SURMEIER, D. J, MALENKA, R. C

“…The striatum and its ventral extension, the nucleus accumbens, are involved in behaviors as diverse as motor planning, drug seeking, and learning. Invariably,…”
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Brain-Derived Neurotrophic Factor (BDNF) Modulates Inhibitory, But Not Excitatory, Transmission in the CA1 Region of the Hippocampus by Frerking, M, Malenka, R. C, Nicoll, R. A

“…M. Frerking 1 , R. C. Malenka 2 , 3 , and R. A. Nicoll 1 , 2 1  Departments of Cellular and Molecular Pharmacology, 2  Physiology, and 3  Psychiatry,…”
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Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus by Baskys, A, Malenka, R C

“…1. The effects of metabotropic glutamate receptor agonists on excitatory synaptic transmission in the CA1 region of rat hippocampal slices (11-30 days) were…”
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Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons by Nicoll, Roger A, Castillo, Pablo E, Malenka, Robert C

“…Glutamate, the neurotransmitter at most excitatory synapses in the brain, activates a variety of receptor subtypes that can broadly be divided into ionotropic…”
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A critical period for long-term potentiation at thalamocortical synapses by Crair, Michael C, Malenka, Robert C

“…In mammalian development, the refinement of topographical projections from the thalamus to the cortex is thought to arise through an activity-dependent process…”
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Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system by Nicoll, R A, Malenka, R C, Kauer, J A

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NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms by Malenka, R C, Nicoll, R A

“…Long-term potentiation in the CA1 region of the hippocampus is the most extensively studied model of activity-dependent synaptic plasticity in the mammalian…”
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Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression by Mulkey, Rosel M, Endo, Shogo, Shenolikar, Shirish, Malenka, Robert C

“…Long-term potentiation (LTP) is a synaptic mechanism thought to be involved in learning and memory. Long-term depression (LTD), an activity-dependent decrease…”
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Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors by Scanziani, Massimo, Salin, Paul A, Vogt, Kaspar E, Malenka, Robert C, Nicoll, Roger A

“…The classical view of fast chemical synaptic transmission is that released neurotransmitter acts locally on postsynaptic receptors and is cleared from the…”
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Postsynaptic Membrane Fusion and Long-Term Potentiation by Lledo, Pierre-Marie, Zhang, Xiangyang, Südhof, Thomas C., Malenka, Robert C., Nicoll, Roger A.

“…The possibility that membrane fusion events in the postsynaptic cell may be required for the change in synaptic strength resulting from long-term potentiation…”
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Reexamination of the effects of MCPG on hippocampal LTP, LTD, and depotentiation by Selig, D K, Lee, H K, Bear, M F, Malenka, R C

“…1. We examined the effects of the metabotropic glutamate receptor (mGluR) antagonist alpha-methyl-4-carboxyphenylglycine (MCPG) on the induction of long-term…”
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Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus by Mulkey, R M, Malenka, R C

“…The mechanisms responsible for long-lasting, activity-dependent decreases in synaptic efficacy are not well understood. We have examined the initial steps…”
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An ER retention signal explains differences in surface expression of NMDA and AMPA receptor subunits by Xia, H, Hornby, Z.D, Malenka, R.C

“…The molecular mechanisms that control the surface expression of NMDA receptors (NMDARs) and AMPA receptors (AMPARs) are unknown. To determine the role of the…”
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Mechanisms underlying induction of long-term potentiation in rat medial and lateral perforant paths in vitro by Colino, A, Malenka, R C

“…1. The mechanisms underlying the induction of long-term potentiation (LTP) in the medial and lateral perforant paths were studied by recording excitatory…”
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Bidirectional Control of Quantal Size by Synaptic Activity in the Hippocampus by Stéphane H. R. Oliet, Malenka, Robert C., Nicoll, Roger A.

“…Analysis of strontium-induced asynchronous release of quanta from stimulated synapses revealed that long-term potentiation and long-term depression in the CA1…”
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