Neurological Complications of First 100 Orthotopic Liver Transplantation Patients in Southern Iran

Neurological Complications of First 100 Orthotopic Liver Transplantation Patients in Southern Iran

Neurological complications which are responsible for significant mortality and morbidity after orthotopic liver transplantation have been reported in 8.3% to 47% of cases in various series. This prospective study was performed to investigate the prevalence and characteristics of neurological complic...

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Bibliographic Details
Published in:Transplantation proceedings Vol. 37; no. 7; pp. 3197 - 3199
Main Authors: Haghighi, A. Borhani, Malekhoseini, S.A., Bahramali, E., Firouzabadi, N., Salahi, H., Bahador, A., Roozbeh, J., Firuzi, M. Saber, Lankarani, K.B., Nikseresht, A.R., Ashkani, H., Janghorban, P.
Format: Journal Article Conference Proceeding
Language:English
Published: New York, NY Elsevier Inc 01-09-2005
Elsevier Science
Subjects:
Biological and medical sciences
Confusion
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Hallucinations
Humans
Liver Transplantation - adverse effects
Liver Transplantation - mortality
Male
Medical sciences
Nervous System Diseases - epidemiology
Postoperative Complications - physiopathology
Prevalence
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Survival Analysis
Tissue, organ and graft immunology
Iran
Asia
Human
Medicine
Orthotopic transplantation
Nervous system diseases
Treatment
Digestive system
Surgery
Liver
Graft
Patient
Homotransplantation
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Summary:Neurological complications which are responsible for significant mortality and morbidity after orthotopic liver transplantation have been reported in 8.3% to 47% of cases in various series. This prospective study was performed to investigate the prevalence and characteristics of neurological complications in the first 100 patients who have undergone orthotopic liver transplantation from 1993 to 2004. Neurological symptoms and signs as well as routine laboratory tests, including complete blood cell counts, electrolyte levels, drug levels, microbiologic and serological studies, brain computed tomography scans, magnetic resonance imaging, and electrodiagnostic studies were reviewed in all patients. Follow-up periods were from 2 months to 10 years. Nineteen patients of mean age of 34.9 years developed neurological complications after orthotopic liver transplantation. The most common neurological symptoms and signs were confusion (42.1% of cases with neurological complications), convulsions (36.8%), and hallucinations (31.6%). Hepatic encephalopathy (31.6%) and drug toxicity (26.2%) were the most common neurological syndromes. The mortality rate was significantly higher among patients with neurological complications. Compared to other centers, neurological complications were less common in our center.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2005.08.025