Search Results - "Malek, Natalia"

Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems-A Novel Treatment Option for Chronic Pain Management by Malek, Natalia, Starowicz, Katarzyna

“…Compared with acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time, and is often…”
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Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in Osteoarthritis by Mlost, Jakub, Kostrzewa, Magdalena, Malek, Natalia, Starowicz, Katarzyna

“…Osteoarthritis (OA) is a joint disease in which cartilage degenerates as a result of mechanical and biochemical changes. The main OA symptom is chronic pain…”
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Knockout of ACTB and ACTG1 with CRISPR/Cas9(D10A) Technique Shows that Non-Muscle β and γ Actin Are Not Equal in Relation to Human Melanoma Cells' Motility and Focal Adhesion Formation by Malek, Natalia, Mrówczyńska, Ewa, Michrowska, Aleksandra, Mazurkiewicz, Ewa, Pavlyk, Iuliia, Mazur, Antonina Joanna

“…Non-muscle actins have been studied for many decades; however, the reason for the existence of both isoforms is still unclear. Here we show, for the first…”
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Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures by Przewlocka, Barbara, Mika, Joanna, Popiolek-Barczyk, Katarzyna, Malek, Natalia, Starowicz, Katarzyna

“…Microglial activation is a polarized process divided into potentially neuroprotective phenotype M2 and neurotoxic phenotype M1, predominant during chronic…”
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The origin of the expressed retrotransposed gene ACTBL2 and its influence on human melanoma cells’ motility and focal adhesion formation by Malek, Natalia, Michrowska, Aleksandra, Mazurkiewicz, Ewa, Mrówczyńska, Ewa, Mackiewicz, Paweł, Mazur, Antonina J.

“…We have recently found that β-actin-like protein 2 (actbl2) forms complexes with gelsolin in human melanoma cells and can polymerize. Phylogenetic and…”
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Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism by Starowicz, Katarzyna, Makuch, Wioletta, Korostynski, Michal, Malek, Natalia, Slezak, Michal, Zychowska, Magdalena, Petrosino, Stefania, De Petrocellis, Luciano, Cristino, Luigia, Przewlocka, Barbara, Di Marzo, Vincenzo

“…Neuropathic pain elevates spinal anandamide (AEA) levels in a way further increased when URB597, an inhibitor of AEA hydrolysis by fatty acid amide hydrolase…”
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The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain by Malek, Natalia, Kostrzewa, Magdalena, Makuch, Wioletta, Pajak, Agnieszka, Kucharczyk, Mateusz, Piscitelli, Fabiana, Przewlocka, Barbara, Di Marzo, Vincenzo, Starowicz, Katarzyna

“…[Display omitted] There is considerable evidence to support the role of anandamide (AEA), an endogenous ligand of cannabinoid receptors, in neuropathic pain…”
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Thymosin β4 Regulates Focal Adhesion Formation in Human Melanoma Cells and Affects Their Migration and Invasion by Makowiecka, Aleksandra, Malek, Natalia, Mazurkiewicz, Ewa, Mrówczyńska, Ewa, Nowak, Dorota, Mazur, Antonina Joanna

“…Thymosin β4 (Tβ4), a multifunctional 44-amino acid polypeptide and a member of actin-binding proteins (ABPs), plays an important role in developmental…”
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Changes in Biomechanical Properties of A375 Cells Due to the Silencing of TMSB4X Expression Are Not Directly Correlated with Alterations in Their Stemness Features by Makowiecka, Aleksandra, Mazurkiewicz, Ewa, Mrówczyńska, Ewa, Malek, Natalia, Battistella, Alice, Lazzarino, Marco, Nowak, Dorota, Mazur, Antonina Joanna

“…Thymosin β4 (Tβ4) is a small, 44-amino acid polypeptide. It has been implicated in multiple processes, including cell movement, angiogenesis, and stemness…”
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Reorganization of the actin cytoskeleton during the formation of neutrophil extracellular traps (NETs) by Mannherz, Hans Georg, Budde, Heidi, Jarkas, Muhammad, Hassoun, Roua, Malek-Chudzik, Natalia, Mazur, Antonina J., Skuljec, Jelena, Pul, Refik, Napirei, Markus, Hamdani, Nazha

“…We analyzed actin cytoskeleton alterations during NET extrusion by neutrophil-like dHL-60 cells and human neutrophils in the absence of DNase1 containing serum…”
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Joint problems arising from lack of repair mechanisms: can cannabinoids help? by Malek, Natalia, Starowicz, Katarzyna

“…Osteoarthritis (OA) is the most common disease of joints, which are complex organs where cartilage, bone and synovium cooperate to allow a range of movements…”
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The importance of TRPV1-sensitisation factors for the development of neuropathic pain by Malek, Natalia, Pajak, Agnieszka, Kolosowska, Natalia, Kucharczyk, Mateusz, Starowicz, Katarzyna

“…Transient receptor potential vanilloid type 1 (TRPV1), classically associated with transduction of high-temperature and low-pH pain, underlies pain…”
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Description of Novel Molecular Factors in Lumbar DRGs and Spinal Cord Factors Underlying Development of Neuropathic Pain Component in the Animal Model of Osteoarthritis by Malek, Natalia, Mlost, Jakub, Kostrzewa, Magdalena, Rajca, Jolanta, Starowicz, Katarzyna

“…Osteoarthritis (OA) is one of the most common joint disorder, with pain accompanied by functional impairment, as the most pronounced clinical symptom…”
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Investigation of the P1' and P2' sites of IQF substrates and their selectivity toward 20S proteasome subunits by Gladysz, Radoslaw, Malek, Natalia, Rut, Wioletta, Drag, Marcin

“…High levels of expression and activity of the 20S proteasome have been linked to many types of pathologies, including neoplasia, autoimmune disorders,…”
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Benefits of Astaxanthin supplementation: selected issues by Małek, Natalia, Emerla, Sara, Brożyna, Aleksandra, Kwiatkowska, Anita, Bydliński, Arkadiusz, Karłowicz, Konrad, Hermanowska, Maria, Lubomirska, Julia, Figurowska, Patrycja, Ciulkiewicz, Łukasz

“…INTRODUCTION: Astaxanthin, a carotenoid compound belonging to the xanthophyll group, occurs naturally in algae, yeast, and marine organisms such as shrimp,…”
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Effects of Hyperbaric Oxygen Therapy in Treatment on Diverse Diseases by Hermanowska, Maria, Lubomirska, Julia, Brożyna, Aleksandra, Kwiatkowska, Anita, Bydliński, Arkadiusz, Karłowicz, Konrad, Małek, Natalia, Emerla, Sara, Figurowska, Patrycja, Ciulkiewicz, Łukasz

“…INTRODUCTION: Hyperbaric oxygen therapy (HBOT) indeed holds significant therapeutic potential across various medical conditions, primarily by increasing the…”
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Role of metabolic syndrome and lifestyle factors in endometrial cancer risk and prevention by Kwiatkowska, Anita, Małek, Natalia, Emerla, Sara, Brożyna, Aleksandra, Bydliński, Arkadiusz, Karłowicz, Konrad, Hermanowska, Maria, Lubomirska, Julia, Figurowska, Patrycja, Ciulkiewicz, Łukasz

“…Introduction: The incidence of endometrial cancer, the sixth most common cancer among women, has been rising, especially in developed countries, possibly due…”
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Targeting Microglial Immunoproteasome: A Novel Approach in Neuroinflammatory-Related Disorders by Malek, Natalia, Gladysz, Radoslaw, Stelmach, Natalia, Drag, Marcin

“…It is widely acknowledged that the aging process is linked to the accumulation of damaged and misfolded proteins. This phenomenon is accompanied by a decrease…”
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Spinal and Bulbar Muscular Atrophy – Genetic Causes, Clinical Presentation and Treatment Perspectives by Emerla, Sara, Małek, Natalia, Karłowicz, Konrad, Brożyna, Aleksandra, Kwiatkowska, Anita, Bydliński, Arkadiusz, Hermanowska, Maria, Lubomirska, Julia, Figurowska, Patrycja, Ciulkiewicz, Łukasz

“…Introduction and Purpose: Spinal bulbar muscular atrophy (SBMA), also known as Kennedy's disease, is a rare genetic disorder characterized by progressive…”
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Sex differences in peripheral not central immune responses to pain-inducing injury by Lopes, Douglas M., Malek, Natalia, Edye, Michelle, Jager, Sara Buskbjerg, McMurray, Sheridan, McMahon, Stephen B., Denk, Franziska

“…Women suffer chronic pain more frequently than men. It is not clear whether this is due to differences in higher level cognitive processes or basic nociceptive…”
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