Search Results - "Malek, N. P."

The German Network for Personalized Medicine to enhance patient care and translational research by Illert, A. L., Stenzinger, A., Bitzer, M., Horak, P., Gaidzik, V. I., Möller, Y., Beha, J., Öner, Ö., Schmitt, F., Laßmann, S., Ossowski, S., Schaaf, C. P., Hallek, M., Brümmendorf, T. H., Albers, P., Fehm, T., Brossart, P., Glimm, H., Schadendorf, D., Bleckmann, A., Brandts, C. H., Esposito, I., Mack, E., Peters, C., Bokemeyer, C., Fröhling, S., Kindler, T., Algül, H., Heinemann, V., Döhner, H., Bargou, R., Ellenrieder, V., Hillemanns, P., Lordick, F., Hochhaus, A., Beckmann, M. W., Pukrop, T., Trepel, M., Sundmacher, L., Wesselmann, S., Nettekoven, G., Kohlhuber, F., Heinze, O., Budczies, J., Werner, M., Nikolaou, K., Beer, A. J., Tabatabai, G., Weichert, W., Keilholz, U., Boerries, M., Kohlbacher, O., Duyster, J., Thimme, R., Seufferlein, T., Schirmacher, P., Malek, N. P.

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Molecular therapy for the treatment of hepatocellular carcinoma by Greten, T F, Korangy, F, Manns, M P, Malek, N P

“…Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Conventional cytotoxic chemotherapy has failed to show a substantial benefit for…”
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Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments by Ehmann, D., Wendler, J., Koeninger, L., Larsen, I. S., Klag, T., Berger, J., Marette, A., Schaller, M., Stange, E. F., Malek, N. P., Jensen, B. A. H., Wehkamp, J.

“…Antimicrobial peptides, in particular α-defensins expressed by Paneth cells, control microbiota composition and play a key role in intestinal barrier function…”
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Combination of Conservative and Interventional Therapy Strategies for Intra- and Extrahepatic Cholangiocellular Carcinoma : A Retrospective Survival Analysis by Wedemeyer, Jochen, Schneider, Andrea S., Knüppel, M., Greten, T., Papendorf, F., Schneider, M., Kubicka, Stefan, Vogel, A., Malek, N. P.

“…Background. Due to the predominantly advanced stage at the time of diagnosis treatment of cholangiocarcinoma is difficult. Apart from surgical resection,…”
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Bacterial Periplasmic Oxidoreductases Control the Activity of Oxidized Human Antimicrobial β-Defensin 1 by Wendler, J, Ehmann, D, Courth, L, Schroeder, B O, Malek, N P, Wehkamp, J

“…The antimicrobial peptide human β-defensin 1 (hBD1) is continuously produced by epithelial cells in many tissues. Compared to other defensins, hBD1 has only…”
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Biomarkers Apo10 and TKTL1: Epitope-detection in monocytes (EDIM) as a new diagnostic approach for cholangiocellular, pancreatic and colorectal carcinoma by Saman, S, Stagno, M J, Warmann, S W, Malek, N P, Plentz, R R, Schmid, E

“…The EDIM (Epitope detection in monocytes) blood test is based on two biomarkers Apo10 and TKTL1. Apo10 is responsible for cell proliferation and resistance to…”
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Diagnosis of and therapy for hepatocellular carcinoma by Greten, T F, Malek, N P, Schmidt, S, Arends, J, Bartenstein, P, Bechstein, W, Bernatik, T, Bitzer, M, Chavan, A, Dollinger, M, Domagk, D, Drognitz, O, Düx, M, Farkas, S, Folprecht, G, Galle, P, Geißler, M, Gerken, G, Habermehl, D, Helmberger, T, Herfarth, K, Hoffmann, R T, Holtmann, M, Huppert, P, Jakobs, T, Keller, M, Klempnauer, J, Kolligs, F, Körber, J, Lang, H, Lehner, F, Lordick, F, Lubienski, A, Manns, M P, Mahnken, A, Möhler, M, Mönch, C, Neuhaus, P, Niederau, C, Ocker, M, Otto, G, Pereira, P, Pott, G, Riemer, J, Ringe, K, Ritterbusch, U, Rummeny, E, Schirmacher, P, Schlitt, H J, Schlottmann, K, Schmitz, V, Schuler, A, Schulze-Bergkamen, H, von Schweinitz, D, Seehofer, D, Sitter, H, Straßburg, C P, Stroszczynski, C, Strobel, D, Tannapfel, A, Trojan, J, van Thiel, I, Vogel, A, Wacker, F, Wedemeyer, H, Wege, H, Weinmann, A, Wittekind, C, Wörmann, B, Zech, C J

“…The interdisciplinary guidelines at the S3 level on the diagnosis of and therapy for hepatocellular carcinoma (HCC) constitute an evidence- and consensus-based…”
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Concanavalin A-induced liver injury triggers hepatocyte proliferation by Trautwein, C, Rakemann, T, Malek, N P, Plümpe, J, Tiegs, G, Manns, M P

“…Concanavalin A (Con A) injection into mice leads to immune-mediated liver injury. We studied whether after Con A-induced liver injury, TNF- and IL-6-dependent…”
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Primary perivascular epitheloid cell tumour (PEComa) of the liver - is a new entity of the liver tumors? by Panahova, S, Rempp, H, Sipos, B, Malek, N P, Boozari, B

“…Perivascular epitheloid cell tumor (PEComa) is a rare tumor, characterized by dual Expression of smooth muscle and melanocytic markers. Due to the development…”
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Efficacy and safety of telaprevir (TVR) triple therapy in a 'real-life' cohort of 102 patients with HCV genotype 1: interim analysis after 24 weeks of treatment by Werner, C. R., Franz, C., Egetemeyr, D. P., Janke-Maier, P., Malek, N. P., Lauer, U. M., Berg, C. P.

“…Summary Since 2011, telaprevir (TVR)‐based triple therapy is the new treatment standard for hepatitis C genotype 1 virus infection. The aim of our…”
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Recurrent pyogenic cholangitis as a differential diagnosis in biliary tract diseases by Wagner, V, Plentz, R R, Schraml, C, Malek, N P, Goetz, M

“…Recurrent Pyogenic Cholangitis (RPC) or Primary Hepatolithiasis is a common disease of the biliary tract in Asia, whereas it is usually not seen in Europeans…”
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FOLFIRINOX as first-line treatment for unresectable acinar cell carcinoma of the pancreas: a case report by Schempf, U, Sipos, B, König, C, Malek, N P, Bitzer, M, Plentz, R R

“…Pancreatic acinar cell carcinoma (ACC) is a rare, aggressive variant of pancreatic ductal adenocarcinoma. Surgery is the only curative treatment option and…”
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AFP-producing adenocarcinoma of the esophagogastric junction: report of a case with atypical immunohistochemical findings responding to palliative chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT regime) by Häussler, U, Bitzer, M, Bösmüller, H, Clasen, S, Götz, M, Malek, N P, Plentz, R R

“…AFP-producing adenocarcinoma of the esophagus and esophagogastric junction are rare tumor diseases. These tumors show an aggressive behavior characterized by…”
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Caspase 8 Small Interfering RNA Prevents Acute Liver Failure in Mice by Zender, Lars, Hütker, Sebastian, Liedtke, Christian, Tillmann, Hans Ludger, Zender, Steffen, Mundt, Bettina, Waltemathe, Morlen, Gösling, Thomas, Flemming, Peer, Malek, Nisar Peter, Trautwein, Christian, Manns, Michael Peter, Kühnel, Florian, Kubicka, Stefan

“…A major concern in therapy of acute liver failure is protection of hepatocytes to prevent apoptosis and maintain liver function. Small interfering RNA (siRNA)…”
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Treatment of recurrent genotype 1 hepatitis C post-liver transplantation: single center experience with telaprevir-based triple therapy by Werner, C R, Egetemeyr, D P, Nadalin, S, Königsrainer, A, Malek, N P, Lauer, U M, Berg, C P

“…Recurrent HCV infection post-liver transplantation (post-LT) is still a major challenge in the treatment of hepatitis C virus (HCV) infection. In this…”
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OTSC-assisted resection of a duodenal neuroendocrine tumor: a case report by Schempf, U, Kratt, T, Hoetker, M, Stüker, D, Plentz, R R, Malek, N P, Goetz, M

“…The over the scope clip (OTSC) is mainly used for closure of gastrointestinal endoluminal defects and treatment of gastrointestinal bleeding. Its use for…”
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Proximal duodenal obstruction--Bouveret's syndrome revisited by Werner, C R, Graepler, F, Glatzle, J, Stüker, D, Kratt, T, Schmehl, J, Bitzer, M, Königsrainer, A, Malek, N P, Goetz, M

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Personalization in the medicine of the future : Opportunities and risks by Malek, N P

“…Personalized medicine is not a new concept. The renaissance of the term is due to the enormous progress in gene sequencing technology and functional imaging,…”
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A case of the yellow nail syndrome associated with massive chylous ascites, pleural and pericardial effusions by Malek, N P, Ocran, K, Tietge, U J, Maschek, H, Gratz, K F, Trautwein, C, Wagner, S, Manns, M P

“…A 26-year-old male patient with a history of chronic peripheral lymphedema, yellowish coloured slow growing nails and pleural effusions since early childhood…”
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Personalized treatment of cholangiocellular carcinoma (CCA) by Jödicke, L, Zender, L, Malek, N P

“…Cholangiocellular carcinoma (CCA) is one of the primary liver tumors and overall represents a rare malignancy; however, in recent years the incidence,…”
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