Search Results - "Malecek, Karolina"

T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy by Zhong, Shi, Malecek, Karolina, Johnson, Laura A., Yu, Zhiya, de Miera, Eleazar Vega-Saenz, Darvishian, Farbod, McGary, Katelyn, Huang, Kevin, Boyer, Josh, Corse, Emily, Shao, Yongzhao, Rosenberg, Steven A., Restifo, Nicholas P., Osman, Iman, Krogsgaard, Michelle

“…T cells expressing antigen-specific T-cell receptors (TCRs) can mediate effective tumor regression, but they often also are accompanied by autoimmune…”
Get full text

Specific increase in potency via structure-based design of a TCR by Malecek, Karolina, Grigoryan, Arsen, Zhong, Shi, Gu, Wei Jun, Johnson, Laura A, Rosenberg, Steven A, Cardozo, Timothy, Krogsgaard, Michelle

“…Adoptive immunotherapy with Ag-specific T lymphocytes is a powerful strategy for cancer treatment. However, most tumor Ags are nonreactive "self" proteins,…”
Get full text

Immunoglobulin heavy chain exclusion in the shark by Malecek, Karolina, Lee, Victor, Feng, Wendy, Huang, Jing Li, Flajnik, Martin F, Ohta, Yuko, Hsu, Ellen

“…The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes. Adaptive…”
Get full text

2D TCR–pMHC–CD8 kinetics determines T‐cell responses in a self‐antigen‐specific TCR system by Liu, Baoyu, Zhong, Shi, Malecek, Karolina, Johnson, Laura A., Rosenberg, Steven A., Zhu, Cheng, Krogsgaard, Michelle

“…Two‐dimensional (2D) kinetic analysis directly measures molecular interactions at cell–cell junctions, thereby incorporating inherent cellular effects. By…”
Get full text

Impact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts by Weiss, Sarah A, Han, Joseph, Darvishian, Farbod, Tchack, Jeremy, Han, Sung Won, Malecek, Karolina, Krogsgaard, Michelle, Osman, Iman, Zhong, Judy

“…Age has been reported as an independent prognostic factor for melanoma-specific survival (MSS). We tested the hypothesis that age impacts the host anti-tumor…”
Get full text

The Expression Quantitative Trait Loci in Immune Pathways and their Effect on Cutaneous Melanoma Prognosis by Vogelsang, Matjaz, Martinez, Carlos N, Rendleman, Justin, Bapodra, Anuj, Malecek, Karolina, Romanchuk, Artur, Kazlow, Esther, Shapiro, Richard L, Berman, Russell S, Krogsgaard, Michelle, Osman, Iman, Kirchhoff, Tomas

“…The identification of personalized germline markers with biologic relevance for the prediction of cutaneous melanoma prognosis is highly demanded but to date,…”
Get full text

Engineering improved T cell receptors using an alanine-scan guided T cell display selection system by Malecek, Karolina, Zhong, Shi, McGary, Katelyn, Yu, Connie, Huang, Kevin, Johnson, Laura A., Rosenberg, Steven A., Krogsgaard, Michelle

“…T cell receptors (TCRs) on T cells recognize peptide-major histocompatibility complex (pMHC) molecules on the surface of antigen presenting cells and this…”
Get full text

2 D TCR –p MHC – CD 8 kinetics determines T ‐cell responses in a self‐antigen‐specific TCR system by Liu, Baoyu, Zhong, Shi, Malecek, Karolina, Johnson, Laura A., Rosenberg, Steven A., Zhu, Cheng, Krogsgaard, Michelle

“…Two‐dimensional (2 D ) kinetic analysis directly measures molecular interactions at cell–cell junctions, thereby incorporating inherent cellular effects. By…”
Get full text

Specific increase in potency via structure-based design of a T cell receptor by Malecek, Karolina, Grigoryan, Arsen, Zhong, Shi, Gu, Wei Jun, Johnson, Laura A., Rosenberg, Steven A., Cardozo, Timothy, Krogsgaard, Michelle

“…Adoptive immunotherapy with antigen-specific T lymphocytes is a powerful strategy for cancer treatment. However, most tumor antigens are non-reactive “self”…”
Get full text

Specific increase in T-cell potency via structure-based design of a T-cell receptor for adoptive immunotherapy by Malecek, Karolina, Grigoryan, Arsen, Zhong, Shi, Gu, Wei Jun, Johnson, Laura A., Rosenberg, Steven A., Cardozo, Timothy, Krogsgaard, Michelle

“…Abstract only…”
Get full text

The Evolution of Multiple Isotypic IgM Heavy Chain Genes in the Shark by Lee, Victor, Huang, Jing Li, Lui, Ming Fai, Malecek, Karolina, Ohta, Yuko, Mooers, Arne, Hsu, Ellen

“…The IgM H chain gene organization of cartilaginous fishes consists of 15-200 miniloci, each with a few gene segments (V(H)-D1-D2-J(H)) and one C gene. This is…”
Get full text

2081: Phenotypic characterization of the CD4+ T-cell response during anti-CTLA4 therapy with ipilimumab in melanoma patients by Sherani, Farha, Moogk, Duane, Bapodra, Anuj, Malecek, Karolina, Moran, Una, Lee, Yesung, Osman, Iman, Krogsgaard, Michelle

“…OBJECTIVES/SPECIFIC AIMS: To characterize the CD4+ T-cell response during CTLA-4 blockade immunotherapy with ipilimumab in patients with metastatic melanoma by…”
Get full text

2081 by Farha Sherani, Duane Moogk, Anuj Bapodra, Karolina Malecek, Una Moran, Yesung Lee, Iman Osman, Michelle Krogsgaard

“…OBJECTIVES/SPECIFIC AIMS: To characterize the CD4+ T-cell response during CTLA-4 blockade immunotherapy with ipilimumab in patients with metastatic melanoma by…”
Get full text

Retroviral transduction of T-cell receptors in mouse T-cells by Zhong, Shi, Malecek, Karolina, Perez-Garcia, Arianne, Krogsgaard, Michelle

“…T-cell receptors (TCRs) play a central role in the immune system. TCRs on T-cell surfaces can specifically recognize peptide antigens presented by antigen…”
Get full text

“Allelic” exclusion despite 15 IgH loci in nurse shark (35.2) by Lee, Victor, Malecek, Karolina, Hsu, Ellen

“…Nurse sharks have an alternative IgH organization consisting of 15 independent miniloci (VH-D1-D2-JH-Cμ). Rearrangement takes place primarily within the locus,…”
Get full text

Biophysical Analysis of T Cell Receptor Functional Discrimination for Self Tumor Antigen by Malecek, Karolina

“…Adoptive immunotherapy with antigen-specific T lymphocytes is a powerful strategy for cancer treatment. However, most tumor antigens are non-reactive, "self"…”
Get full text

Retroviral Transduction of T-cell Receptors in Mouse T-cells by Zhong, Shi, Malecek, Karolina, Perez-Garcia, Arianne, Krogsgaard, Michelle

Get full text

Somatic Hypermutation and Junctional Diversification at Ig Heavy Chain Loci in the Nurse Shark by Malecek, Karolina, Brandman, Julie, Brodsky, Jennie E, Ohta, Yuko, Flajnik, Martin F, Hsu, Ellen

“…We estimate there are approximately 15 IgM H chain loci in the nurse shark genome and have characterized one locus. It consists of one V, two D, and one J…”
Get full text

The Evolution of Multiple Isotypic IgM Heavy Chain Genes in the Shark1 by Lee, Victor, Huang, Jing Li, Lui, Ming Fai, Malecek, Karolina, Ohta, Yuko, Mooers, Arne, Hsu, Ellen

“…The IgM H chain gene organization of cartilaginous fishes consists of 15–200 miniloci, each with a few gene segments (V H -D1-D2-J H ) and one C gene. This is…”
Get full text

Specific increase in T cell potency via structure-based design of a T cell receptor for adoptive immunotherapy by Malecek, Karolina, Grigoryan, Arsen, Zhong, Shi, Gu, Wei Jun, Johnson, Laura A, Rosenberg, Steven A, Cardozo, Timothy, Krogsgaard, Michelle

“…Adoptive immunotherapy with antigen-specific T lymphocytes is a powerful strategy for cancer treatment. However, most tumor antigens are non-reactive "self"…”
Get full text