Effect of Adenosine on Injury Caused by Ischemia and Reperfusion in Rats: Functional and Morphologic Study

Abstract To study whether treatment with adenosine (ADO), an agonist of adenosine receptors, attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), we treated rats with ADO (15 mg/kg or saline solution (SS) intravenously before 60 minutes occlusion of the superior mesenteric a...

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Published in:	Transplantation proceedings Vol. 44; no. 8; pp. 2317 - 2320
Main Authors:	Haddad, M.A, Miranda-Ferreira, R, Taha, N.S.A, Maldonado, V.C, Daroz, R.R, Daud, M.O, Neto, J. Lima, Muniz, D.A, Silva, P.C.S, Monteiro, H.P, Fagundes, D.J, Caricati-Neto, A, Taha, M.O
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Amsterdam Elsevier Inc 01-10-2012 Elsevier
Subjects:	Adenosine - pharmacology Animals Biological and medical sciences Cardiology. Vascular system Cytoprotection Disease Models, Animal Electric Stimulation Enteric Nervous System - drug effects Enteric Nervous System - physiopathology Fundamental and applied biological sciences. Psychology Fundamental immunology Gastrointestinal Agents - pharmacology Gastrointestinal Motility - drug effects Jejunum - blood supply Jejunum - drug effects Jejunum - innervation Jejunum - pathology Jejunum - physiopathology Medical sciences Potassium Chloride - pharmacology Rats Rats, Wistar Reperfusion Injury - pathology Reperfusion Injury - physiopathology Reperfusion Injury - prevention & control Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Purine nucleoside Adenosine Rat Ischemia reperfusion Rodentia Transplantation Trauma Medicine Vertebrata Mammalia Treatment Surgery Animal Morphology Graft Lesion
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Summary:	Abstract To study whether treatment with adenosine (ADO), an agonist of adenosine receptors, attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), we treated rats with ADO (15 mg/kg or saline solution (SS) intravenously before 60 minutes occlusion of the superior mesenteric artery (I) and/or 120 minutes after its release (R). After I or I/R, isolated jejunal segments (2 cm) were mounted in an organ bath to study nerve-mediated contractions stimulated by electrical pulses or KCI with the use of a digital recording system. Thin jejunal slices were stained with hematoxylin and eosin for optical microscopy. Compared with the sham group, jejunal contractions were reduced in I+SS and IR+SS but similar after treatment with ADO (I+ADO and IR+ADO groups). We concluded that rat jejunal enteric nerves were damaged in I+SS and IR+SS but not in the I+ADO and IR+ADO groups. These results suggested that ADO attenuated intestinal dysfunction due to I and R.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2012.07.057