Dual trigger improves response to ovarian stimulation and ICSI outcomes in patients with a previous r-hCG triggered ICSI cycle

To evaluate if ovarian response to controlled ovarian stimulation (COS) and intracytoplasmic sperm injection (ICSI) outcomes are improved by the use of dual trigger (gonadotropin-releasing hormone (GnRH) agonists plus recombinant human chorionic gonadotropin (r-hCG)) in patients with previous cycles...

Full description

Saved in:

Bibliographic Details
Published in:	JBRA assisted reproduction Vol. 26; no. 2; pp. 255 - 260
Main Authors:	Setti, Amanda Souza, Maldonado, Luis Guilherme Louzada, Braga, Daniela Paes de Almeida Ferreira, Iaconelli, Jr, Assumpto, Borges, Jr, Edson
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction) 2022 Brazilian Society of Assisted Reproduction
Subjects:	Age Body mass index Case-Control Studies Chorionic Gonadotropin - therapeutic use Demographics Embryos Female Fertilization in Vitro Gonadotropin-Releasing Hormone Humans Infertility Miscarriage Oocytes Original Ovaries Ovulation Induction Pregnancy Pregnancy Rate Recombinant Proteins Sperm Sperm Injections, Intracytoplasmic Variables New York United States > US Switzerland ICSI implantation oocyte maturation ovarian stimulation
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	To evaluate if ovarian response to controlled ovarian stimulation (COS) and intracytoplasmic sperm injection (ICSI) outcomes are improved by the use of dual trigger (gonadotropin-releasing hormone (GnRH) agonists plus recombinant human chorionic gonadotropin (r-hCG)) in patients with previous cycles triggered with r-hCG. This case-control study included 88 matched cycles performed in 88 patients, which had the first ICSI cycle triggered with r-hCG (n=44), and the following ICSI cycle with dual trigger (n=44). We compared the cycle outcomes between the groups. In a second case-control within-subject analyses, we compared the ICSI outcomes between patients which had the first ICSI cycle triggered with r-hCG only (n=18), and the following ICSI cycle with dual trigger (n=18) or r-hCG only (n=18). Upon investigating repeated cycles (r-hCG only vs. dual trigger), we found higher oocyte yield and mature oocyte rates, lower immature oocyte rates, higher fertilization rates, and higher blastocyst development rates; and higher rates of cycles with embryos transferred and implantation in the dual trigger cycle. The dual trigger regimen is a more effective approach than r-hCG trigger in patients with a previous r-hCG triggered ICSI cycle, yielding improved response to COS, and better laboratorial and clinical outcomes.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1518-0557 1517-5693 1518-0557
DOI:	10.5935/1518-0557.20210065