Search Results - "Malcov, Hagar"
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1
Enhancer methylation dynamics contribute to cancer plasticity and patient mortality
Published in Genome research (01-05-2016)“…During development, enhancers play pivotal roles in regulating gene expression programs; however, their involvement in cancer progression has not been fully…”
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2
Melanoma miRNA trafficking controls tumour primary niche formation
Published in Nature cell biology (01-09-2016)“…Melanoma originates in the epidermis and becomes metastatic after invasion into the dermis. Prior interactions between melanoma cells and dermis are poorly…”
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3
Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors
Published in Nature communications (23-03-2015)“…Decoding heterogeneity of pluripotent stem cell (PSC)-derived neural progeny is fundamental for revealing the origin of diverse progenitors, for defining their…”
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4
Mutated MITF-E87R in Melanoma Enhances Tumor Progression via S100A4
Published in Journal of investigative dermatology (01-10-2018)“…Melanoma, a melanocyte origin neoplasm, is the most lethal type of skin cancer, and incidence is increasing. Several familial and somatic mutations have been…”
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Ataxia Telangiectasia Mutated Signaling Delays Skin Pigmentation upon UV Exposure by Mediating MITF Function toward DNA Repair Mode
Published in Journal of investigative dermatology (01-12-2023)“…Skin pigmentation is paused after sun exposure; however, the mechanism behind this pausing is unknown. In this study, we found that the UVB-induced DNA repair…”
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6
UV-Protection Timer Controls Linkage between Stress and Pigmentation Skin Protection Systems
Published in Molecular cell (01-11-2018)“…Skin sun exposure induces two protection programs: stress responses and pigmentation, the former within minutes and the latter only hours afterward. Although…”
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Slow Transcription of the 99a/let-7c/125b-2 Cluster Results in Differential MiRNA Expression and Promotes Melanoma Phenotypic Plasticity
Published in Journal of investigative dermatology (01-12-2021)“…Almost half of the human microRNAs (miRNAs) are encoded in clusters. Although transcribed as a single unit, the levels of individual mature miRNAs often…”
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Food-seeking behavior is triggered by skin ultraviolet exposure in males
Published in Nature metabolism (11-07-2022)“…Sexual dimorphisms are responsible for profound metabolic differences in health and behavior. Whether males and females react differently to environmental…”
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