Search Results - "Malcolmson, Richard"

Physical Characterization of Tobramycin Inhalation Powder: I. Rational Design of a Stable Engineered-Particle Formulation for Delivery to the Lungs by Miller, Danforth P, Tan, Trixie, Tarara, Thomas E, Nakamura, John, Malcolmson, Richard J, Weers, Jeffry G

“…A spray-dried engineered particle formulation, Tobramycin Inhalation Powder (TIP), was designed through rational selection of formulation composition and…”
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Physical Characterization of Tobramycin Inhalation Powder: II. State Diagram of an Amorphous Engineered Particle Formulation by Miller, Danforth P, Tan, Trixie, Nakamura, John, Malcolmson, Richard J, Tarara, Thomas E, Weers, Jeffry G

“…Tobramycin Inhalation Powder (TIP) is a spray-dried engineered particle formulation used in TOBI Podhaler, a drug-device combination for treatment of cystic…”
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Dry powder formulations for pulmonary delivery by Malcolmson, Richard J, Embleton, Jonathan K

“…This review examines the key issues surrounding the development and preparation of formulations for dry powder inhalers. The various inhaler devices that are…”
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Inhalation of tobramycin using simulated cystic fibrosis patient profiles by Haynes, Alfred, Geller, David, Weers, Jeffry, Ament, Brian, Pavkov, Richard, Malcolmson, Richard, Debonnett, Laurie, Mastoridis, Paul, Yadao, Anthony, Heuerding, Silvia

“…Summary Introduction TOBI® Podhaler™ is a capsule‐based drug‐device combination (tobramycin inhalation powder [TIP] 28 mg capsules via unit‐dose dry powder…”
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Novel Methods for the Assessment of Safety Pharmacology and Toxicology Parameters in Anesthetized and Ventilated Dogs Receiving Inhaled Drugs by Bujold, Kim, Pfeiffer, Juergen, Authier, Simon, Malcolmson, Richard, Fink, Jim, Tepper, Jeff

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Novel Toxicology Program to Support the Development of Inhaled VentaProst by Tepper, Jeffrey, Pfeiffer, Juergen, Bujold, Kim, Fink, James B., Malcolmson, Richard, Sullivan, Dennis, Authier, Simon, Entcheva-Dimitrov, Plamena, Clark, Andrew

“…Currently, off-label continuous administration of inhaled epoprostenol is used to manage hemodynamics during mitral valve surgery. A toxicology program was…”
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Idealhalers Versus Realhalers: Is It Possible to Bypass Deposition in the Upper Respiratory Tract? by Weers, Jeffry G, Son, Yoen-Ju, Glusker, Mark, Haynes, Alfred, Huang, Daniel, Kadrichu, Nani, Le, John, Li, Xue, Malcolmson, Richard, Miller, Danforth P, Tarara, Thomas E, Ung, Keith, Clark, Andy

“…This review discusses how advances in formulation and device design can be utilized to dramatically improve lung targeting and dose consistency relative to…”
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Inhalation of tobramycin using simulated cystic fibrosis patient profiles: TIP Inhalation in CF by Haynes, Alfred, Geller, David, Weers, Jeffry, Ament, Brian, Pavkov, Richard, Malcolmson, Richard, Debonnett, Laurie, Mastoridis, Paul, Yadao, Anthony, Heuerding, Silvia

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Best practices for managing quality and safety of foreign particles in orally inhaled and nasal drug products, and an evaluation of clinical relevance by Blanchard, James, Coleman, James, Crim, Courtney, Dabreu-Hayling, Claire, Fries, Lou, Ghaderi, Raouf, Haeberlin, Barbara, Malcolmson, Richard, Mittelman, Stanley, Nagao, Lee, Saracovan, Ilie, Shtohryn, Liuda, Snodgrass-Pilla, Caesar, Sundahl, Mikael, Wolff, Ronald

“…In a previous paper, the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS) outlined the progression of regulatory…”
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Foreign particles testing in orally inhaled and nasal drug products by Blanchard, James, Coleman, James, Hayling, Claire D'Abreu, Ghaderi, Raouf, Haeberlin, Barbara, Hart, John, Jensen, Steen, Malcolmson, Richard, Mittelman, Stanley, Nagao, Lee M, Sekulic, Sonja, Snodgrass-Pilla, Caesar, Sundahl, Mikael, Thompson, Glenn, Wolff, Ronald

“…The International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS) presents this paper in order to contribute to public discussion…”
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EXUBERA: pharmaceutical development of a novel product for pulmonary delivery of insulin by White, Steven, Bennett, David B, Cheu, Scot, Conley, Patrick W, Guzek, Donald B, Gray, Steven, Howard, John, Malcolmson, Richard, Parker, Joann M, Roberts, Phil, Sadrzadeh, Negar, Schumacher, Jacqueline D, Seshadri, Sangita, Sluggett, Gregory W, Stevenson, Cynthia L, Harper, Nancy J

“…Development of a product for pulmonary delivery of insulin presented significant technology challenges for this first-in-class pharmaceutical product. These…”
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The use of small volume ocular sprays to improve the bioavailability of topically applied ophthalmic drugs by Martini, Luigi G., Embleton, Jonathan K., Malcolmson, Richard J., Wilson, Clive G.

“…It is accepted that the standard eyedrop volume of 25–50 μl is too large to be accommodated within the conjunctival sac, leading to overspill and to rapid…”
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Cooperative unit and enthalpy studies of cholesterol and cholesteryl esters in dimyristoylphosphatidylcholine liposomes by Malcolmson, R J, Beswick, P H, Higinbotham, J, Privat, P O, Saunier, L

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