Search Results - "Malcolm, Archie J"

p53 is Nuclear and Functional in Both Undifferentiated and Differentiated Neuroblastoma by Chen, Lindi, Malcolm, Archie J., Wood, Katrina M., Cole, Michael, Variend, Sadick, Cullinane, Catherine, Pearson, Andrew D.J., Lunec, John, Tweddle, Deborah A.

“…Aberrant cytoplasmic sequestration has been reported as an alternative mechanism of p53 inactivation to mutation in neuroblastoma. We hypothesized that p53…”
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Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell line by TWEDDLE, Deborah A, MALCOLM, Archie J, BOWN, Nick, PEARSON, Andrew D. J, LUNEC, John

“…p53 mutations are rare in neuroblastomas at diagnosis perhaps accounting for their initial response to therapy, but advanced neuroblastoma frequently relapses,…”
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p53 Cellular Localization and Function in Neuroblastoma : Evidence for Defective G1 Arrest Despite WAF1 Induction in MYCN-Amplified Cells by Tweddle, Deborah A, Malcolm, Archie J, Cole, Michael, Pearson, Andrew D.J, Lunec, John

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Effector Mechanisms of Fenretinide-Induced Apoptosis in Neuroblastoma by Lovat, Penny E., Ranalli, Marco, Annichiarrico-Petruzzelli, Margherita, Bernassola, Francesca, Piacentini, Mauro, Malcolm, Archie J., Pearson, Andy D.J., Melino, Gerry, Redfern, Christopher P.F.

“…Fenretinide is an effective inducer of apoptosis in many malignancies but its precise mechanism(s) of action in the induction of apoptosis in neuroblastoma is…”
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Synergistic induction of apoptosis of neuroblastoma by fenretinide or CD437 in combination with chemotherapeutic drugs by Lovat, Penny E., Ranalli, Marco, Bernassola, Francesca, Tilby, Mike, Malcolm, Archie J., Pearson, Andy D.J., Piacentini, Mauro, Melino, Gerry, Redfern, Christopher P.F.

“…Retinoic acid therapy improves the survival of children with neuroblastoma and 13‐cis retinoic acid now forms an important component of treatment for residual…”
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Neoadjuvant Chemotherapy With Doxorubicin and Cisplatin in Malignant Fibrous Histiocytoma of Bone: A European Osteosarcoma Intergroup Study by BRAMWELL, V. H. C, STEWARD, W. P, USCINSKA, B, KIRKPATRICK, A. L, MACHIN, D, VAN GLABBEKE, M. M, NOOIJ, M, WHELAN, J, CRAFT, A. W, GRIMER, R. J, TAMINAU, A. H. M, CANNON, S. R, MALCOLM, A. J, HOGENDOORN, P. C. W

“…Studies involving small case series have suggested that malignant fibrous histiocytoma of bone (MFH-B) is a chemosensitive tumor and that chemotherapy may…”
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A randomized comparison of two short intensive chemotherapy regimens in children and young adults with osteosarcoma: results in patients with metastases: a study of the European Osteosarcoma Intergroup by Bramwell, V H, Burgers, M V, Souhami, R L, Taminiau, A H, Van Der Eijken, J W, Craft, A W, Malcolm, A J, Uscinska, B, Kirkpatrick, A L, Machin, D, Van Glabbeke, M M

“…Purpose. To report the outcome of 37 patients with metastatic osteosarcoma entered into a large randomized trial (EOI 80831/MRC B002) comparing two different…”
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A pilot, double-blind, controlled 1-year trial of prednisolone treatment in primary biliary cirrhosis: hepatic improvement but greater bone loss by Mitchison, H C, Bassendine, M F, Malcolm, A J, Watson, A J, Record, C O, James, O F

“…A randomized, double-blind, 1-year pilot study of prednisolone treatment for primary biliary cirrhosis was undertaken. Nineteen patients received 30 mg…”
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Differential effects of retinoic acid isomers on the expression of nuclear receptor co-regulators in neuroblastoma by Lovat, Penny E, Annicchiarico-Petruzzelli, Margherita, Corazzari, Marco, Dobson, Mark G, Malcolm, Archie J, Pearson, Andy D.J, Melino, Gerry, Redfern, Christopher P.F

“…Retinoic acid modulates growth and induces differentiation and apoptosis of neuroblastoma cells in vitro, with the all- trans and 9- cis isomers having…”
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9-cis retinoic acid--a better retinoid for the modulation of differentiation, proliferation and gene expression in human neuroblastoma by Lovat, P E, Irving, H, Malcolm, A J, Pearson, A D, Redfern, C P

“…To date, the clinical success of 13-cis or all-trans retinoic acid in the treatment of neuroblastoma has been disappointing. In vivo, 13-cis will isomerise to…”
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Fibrous dysplasia of bone : case report with autopsy study 80 years after the original clinical recognition of the bone lesions by SISSONS, H. A, MALCOLM, A. J

“…We present a report of the histological features of the bone lesions in a case of polyostotic fibrous dysplasia studied at autopsy in a patient aged 88 years…”
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p53 cellular localization and function in neuroblastoma: evidence for defective G(1) arrest despite WAF1 induction in MYCN-amplified cells by Tweddle, D A, Malcolm, A J, Cole, M, Pearson, A D, Lunec, J

“…This study investigated the hypothesis that p53 accumulation in neuroblastoma, in the absence of mutation, is associated with functional inactivation, which…”
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The mechanism of loosening of cemented acetabular components in total hip arthroplasty. Analysis of specimens retrieved at autopsy by Schmalzried, T P, Kwong, L M, Jasty, M, Sedlacek, R C, Haire, T C, O'Connor, D O, Bragdon, C R, Kabo, J M, Malcolm, A J, Harris, W H

“…Late aseptic loosening of cemented acetabular components is governed by the progressive, three-dimensional resorption of the bone immediately adjacent to the…”
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Pathology of bone and soft tissue tumours by Simcock, Paul D, Malcolm, Archie J

“…Primary bone and soft tissue tumours arise within structures derived from the embryological mesoderm and neuroectoderm. They can occur at any site of the body,…”
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Acral pseudolymphomatous angiokeratoma of children by Ramsay, B, Dahl, M C, Malcolm, A J, Wilson-Jones, E

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p53 Cellular Localization and Function in Neuroblastoma by Tweddle, Deborah A., Malcolm, Archie J., Cole, Michael, Pearson, Andrew D.J., Lunec, John

“…This study investigated the hypothesis that p53 accumulation in neuroblastoma, in the absence of mutation, is associated with functional inactivation, which…”
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p53 Cellular Localization and Function in Neuroblastoma: Evidence for Defective G by Tweddle, Deborah A., Malcolm, Archie J., Cole, Michael, Pearson, Andrew D.J., Lunec, John

“…This study investigated the hypothesis that p53 accumulation in neuroblastoma, in the absence of mutation, is associated with functional inactivation, which…”
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Apoptosis of N-type neuroblastoma cells after differentiation with 9-cis-retinoic acid and subsequent washout by LOVAT, P. E, IRVING, H, ANNICCHIARICO-PETRUZZELLI, M, BERNASSOLA, F, MALCOLM, A. J, PEARSON, A. D. J, MELINO, G, REDFERN, C. P. F

“…The overall survival rate for patients with neuroblastoma has improved over the past two decades, but long-term survival for the subgroup of patients with…”
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MHC class II and ICAM-1 expression and lymphocyte subsets in transbronchial biopsies from lung transplant recipients by Milne, D S, Gascoigne, A D, Wilkes, J, Sviland, L, Ashcroft, T, Malcolm, A J, Corris, P A

“…The expression of MHC class II antigens and ICAM-1 and the composition of lymphocyte infiltrates have been studied in frozen sections of transbronchial…”
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MONONUCLEAR PHAGOCYTE POPULATIONS IN THE TRANSPLANTED HUMAN LUNG1 by Milne, Debra S., Gascoigne, Alistair D., Coaker, Julie, Sviland, Lisbet, Ashcroft, Thomas, Malcolm, Archie J., Corris, Paul A.

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