Search Results - "Malcolm, A S"

Erythropoietin Derived by Chemical Synthesis by Wang, Ping, Dong, Suwei, Shieh, Jae-Hung, Peguero, Elizabeth, Hendrickson, Ronald, Moore, Malcolm A. S., Danishefsky, Samuel J.

“…Erythropoietin is a signaling glycoprotein that controls the fundamental process of erythropoiesis, orchestrating the production and maintenance of red blood…”
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Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma by Lou, Emil, Fujisawa, Sho, Morozov, Alexei, Barlas, Afsar, Romin, Yevgeniy, Dogan, Yildirim, Gholami, Sepideh, Moreira, André L, Manova-Todorova, Katia, Moore, Malcolm A S

“…Tunneling nanotubes are long, non-adherent F-actin-based cytoplasmic extensions which connect proximal or distant cells and facilitate intercellular transfer…”
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Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping by Zoellner, Hans, Chami, Belal, Kelly, Elizabeth, Moore, Malcolm A S

“…We recently described a hydrodynamic mechanism for cytoplasmic transfer between cells, termed cell-projection pumping (CPP). Earlier image analysis related…”
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At Last: Erythropoietin as a Single Glycoform by Wang, Ping, Dong, Suwei, Brailsford, John A., Iyer, Karthik, Townsend, Steven D., Zhang, Qiang, Hendrickson, Ronald C., Shieh, JaeHung, Moore, Malcolm A. S., Danishefsky, Samuel J.

“…Wild thing: The first total synthesis of wild‐type erythropoietin glycoprotein (see picture) has been accomplished. The erythropoietic activity of the…”
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A Novel Cartesian Plot Analysis for Fixed Monolayers That Relates Cell Phenotype to Transfer of Contents between Fibroblasts and Cancer Cells by Cell-Projection Pumping by Mahadevan, Swarna, Kwong, Kenelm, Lu, Mingjie, Kelly, Elizabeth, Chami, Belal, Romin, Yevgeniy, Fujisawa, Sho, Manova, Katia, Moore, Malcolm A. S., Zoellner, Hans

“…We recently described cell-projection pumping as a mechanism transferring cytoplasm between cells. The uptake of fibroblast cytoplasm by co-cultured SAOS-2…”
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Extracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells by Saxena, Ashish, Walters, Matthew S., Shieh, Jae-Hung, Shen, Ling-Bo, Gomi, Kazunori, Downey, Robert J., Crystal, Ronald G., Moore, Malcolm A. S.

“…The human airway epithelium lining the bronchial tree contains basal cells that proliferate, differentiate, and communicate with other components of their…”
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Fully Synthetic Granulocyte Colony-Stimulating Factor Enabled by Isonitrile-Mediated Coupling of Large, Side-Chain-Unprotected Peptides by Roberts, Andrew G, Johnston, Eric V, Shieh, Jae-Hung, Sondey, Joseph P, Hendrickson, Ronald C, Moore, Malcolm A. S, Danishefsky, Samuel J

“…Human granulocyte colony-stimulating factor (G-CSF) is an endogenous glycoprotein involved in hematopoiesis. Natively glycosylated and nonglycosylated…”
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Generation of functional hemangioblasts from human embryonic stem cells by Lanza, Robert, Lu, Shi-Jiang, Feng, Qiang, Caballero, Sergio, Chen, Yu, Moore, Malcolm A S, Grant, Maria B

“…Recent evidence suggests the existence of progenitor cells in adult tissues that are capable of differentiating into vascular structures as well as into all…”
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Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin by Lecomte, Nicolas, Njardarson, Jon T, Nagorny, Pavel, Yang, Guangli, Downey, Robert, Ouerfelli, Ouathek, Moore, Malcolm A. S, Danishefsky, Samuel J

“…Migrastatin is a biologically active natural product isolated from Streptomyces that has been shown to inhibit tumor cell migration. Upon completion of the…”
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A novel cell-stiffness-fingerprinting analysis by scanning atomic force microscopy: comparison of fibroblasts and diverse cancer cell lines by Zoellner, Hans, Paknejad, Navid, Manova, Katia, Moore, Malcolm A. S.

“…Differing stimuli affect cell stiffness while cancer metastasis is associated with reduced cell stiffness. Cell stiffness determined by atomic force microscopy…”
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Intercellular communication in malignant pleural mesothelioma: properties of tunneling nanotubes by Ady, Justin W, Desir, Snider, Thayanithy, Venugopal, Vogel, Rachel I, Moreira, André L, Downey, Robert J, Fong, Yuman, Manova-Todorova, Katia, Moore, Malcolm A S, Lou, Emil

“…Malignant pleural mesothelioma is a particularly aggressive and locally invasive malignancy with a poor prognosis despite advances in understanding of cancer…”
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Tumor exosomes induce tunneling nanotubes in lipid raft-enriched regions of human mesothelioma cells by Thayanithy, Venugopal, Babatunde, Victor, Dickson, Elizabeth L., Wong, Phillip, Oh, Sanghoon, Ke, Xu, Barlas, Afsar, Fujisawa, Sho, Romin, Yevgeniy, Moreira, André L., Downey, Robert J., Steer, Clifford J., Subramanian, Subbaya, Manova-Todorova, Katia, Moore, Malcolm A.S., Lou, Emil

“…Tunneling nanotubes (TnTs) are long, non-adherent, actin-based cellular extensions that act as conduits for transport of cellular cargo between connected…”
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Synthesis of granulocyte–macrophage colony-stimulating factor as homogeneous glycoforms and early comparisons with yeast cell-derived material by Zhanga, Qiang, Johnstona, Eric V., Shiehb, Jae-Hung, Mooreb, Malcolm A. S., Danishefsky, Samuel J.

“…Granulocyte–macrophage colony-stimulating factor (GM-CSF) is a medicinally important glycoprotein, used as an immunostimulant following bone-marrow transplant…”
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Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice by Perrier, Anselme L, Topf, Norbert, Barberi, Tiziano, Rubio, Maria E, Calingasan, Noel Y, Bruses, Juan, Studer, Lorenz, Klivenyi, Peter, Beal, M Flint, Moore, Malcolm A S, Kawamata, Hibiki, Harrison, Neil L, Lee, Hyojin, Loonam, Kathleen, Tabar, Viviane

“…Existing protocols for the neural differentiation of mouse embryonic stem (ES) cells require extended in vitro culture, yield variable differentiation results…”
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Smoking accelerates aging of the small airway epithelium by Walters, Matthew S, De, Bishnu P, Salit, Jacqueline, Buro-Auriemma, Lauren J, Wilson, Timothy, Rogalski, Allison M, Lief, Lindsay, Hackett, Neil R, Staudt, Michelle R, Tilley, Ann E, Harvey, Ben-Gary, Kaner, Robert J, Mezey, Jason G, Ashbridge, Beth, Moore, Malcolm A S, Crystal, Ronald G

“…Aging involves multiple biologically complex processes characterized by a decline in cellular homeostasis over time leading to a loss and impairment of…”
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UMG Lenti: novel lentiviral vectors for efficient transgene- and reporter gene expression in human early hematopoietic progenitors by Chiarella, Emanuela, Carrà, Giovanna, Scicchitano, Stefania, Codispoti, Bruna, Mega, Tiziana, Lupia, Michela, Pelaggi, Daniela, Marafioti, Maria G, Aloisio, Annamaria, Giordano, Marco, Nappo, Giovanna, Spoleti, Cristina B, Grillone, Teresa, Giovannone, Emilia D, Spina, Raffaella, Bernaudo, Francesca, Moore, Malcolm A S, Bond, Heather M, Mesuraca, Maria, Morrone, Giovanni

“…Lentiviral vectors are widely used to investigate the biological properties of regulatory proteins and/or of leukaemia-associated oncogenes by stably enforcing…”
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CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity by Yang, Chenyi, Boyson, Cynthia A, Di Liberto, Maurizio, Huang, Xiangao, Hannah, Jeffrey, Dorn, David C, Moore, Malcolm A S, Chen-Kiang, Selina, Zhou, Pengbo

“…Cyclin-dependent kinase (CDK)4 and CDK6 are frequently overexpressed or hyperactivated in human cancers. Targeting CDK4/CDK6 in combination with cytotoxic…”
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The Migrastatin Family:  Discovery of Potent Cell Migration Inhibitors by Chemical Synthesis by Gaul, Christoph, Njardarson, Jón T, Shan, Dandan, Dorn, David C, Wu, Kai-Da, Tong, William P, Huang, Xin-Yun, Moore, Malcolm A. S, Danishefsky, Samuel J

“…The first asymmetric total synthesis of (+)-migrastatin (1), a macrolide natural product with anti-metastatic properties, has been accomplished. Our concise…”
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Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo by Wang, Eunice S., Teruya-Feldstein, Julie, Wu, Yan, Zhu, Zhenping, Hicklin, Daniel J., Moore, Malcolm A.S.

“…The role of angiogenesis in lymphoproliferative diseases is not well established. We demonstrate here that human lymphoma cells secrete vascular endothelial…”
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Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog by Oskarsson, Thordur, Nagorny, Pavel, Krauss, Isaac J, Perez, Lucy, Mandal, Mihirbaran, Yang, Guangli, Ouerfelli, Ouathek, Xiao, Danhua, Moore, Malcolm A. S, Massagué, Joan, Danishefsky, Samuel J

“…A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro…”
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