Search Results - "Malbert, Charles‐Henri"

Vagally Mediated Gut-Brain Relationships in Appetite Control-Insights from Porcine Studies by Malbert, Charles-Henri

“…Signals arising from the upper part of the gut are essential for the regulation of food intake, particularly satiation. This information is supplied to the…”
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Inward Glucose Transfer Accounts for Insulin‐Dependent Increase in Brain Glucose Metabolism Associated with Diet‐Induced Obesity by Bahri, Senda, Horowitz, Michael, Malbert, Charles‐Henri

“…Objective There is a general agreement that there are changes in brain metabolism in insulin‐resistant individuals during conditions of hyperinsulinemia…”
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Obesity-Associated Alterations in Glucose Metabolism Are Reversed by Chronic Bilateral Stimulation of the Abdominal Vagus Nerve by Malbert, Charles-Henri, Picq, Chloé, Divoux, Jean-Louis, Henry, Christine, Horowitz, Michael

“…Acute vagal stimulation modifies glucose and insulin metabolism, but the effect of chronic bilateral vagal stimulation is not known. Our aim was to quantify…”
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Low-calorie sweeteners augment tissue-specific insulin sensitivity in a large animal model of obesity by Malbert, Charles-Henri, Horowitz, Michael, Young, Richard L.

“…Purposes Whether low-calorie sweeteners (LCS), such as sucralose and acesulfame K, can alter glucose metabolism is uncertain, particularly given the…”
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Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis, with limited effects on gut anatomy and function in pigs by Val‐Laillet, David, Guérin, Sylvie, Coquery, Nicolas, Nogret, Isabelle, Formal, Michèle, Romé, Véronique, Le Normand, Laurence, Meurice, Paul, Randuineau, Gwénaëlle, Guilloteau, Paul, Malbert, Charles‐Henri, Parnet, Patricia, Lallès, Jean‐Paul, Segain, Jean‐Pierre

“…Butyrate can improve gut functions, whereas histone deacetylase inhibitors might alleviate neuro‐cognitive alterations. Our aim was to assess whether oral…”
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Impact of gastric emptying and small intestinal transit on blood glucose, intestinal hormones, glucose absorption in the morbidly obese by Nguyen, Nam Q, Debreceni, Tamara L, Burgess, Jenna E, Bellon, Max, Wishart, Judith, Standfield, Scott, Malbert, Charles-Henri, Horowitz, Michael

“…Objective: This study evaluated gastric emptying (GE) and small intestinal (SI) transit in people with morbid obesity and their relationships to glycaemia,…”
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Changes in Brain Activity After a Diet-Induced Obesity by Val‐Laillet, David, Layec, Sabrina, Guérin, Sylvie, Meurice, Paul, Malbert, Charles‐Henri

“…Compared to lean subjects, obese men have less activation in the dorsolateral prefrontal cortex, a brain area implicated in the inhibition of inappropriate…”
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Maternal Western diet during gestation and lactation modifies adult offspring's cognitive and hedonic brain processes, behavior, and metabolism in Yucatan minipigs by Gautier, Yentl, Luneau, Isabelle, Coquery, Nicolas, Meurice, Paul, Malbert, Charles‐Henri, Guerin, Sylvie, Kemp, Bas, Bolhuis, J. Elizabeth, Clouard, Caroline, Le Huërou‐Luron, Isabelle, Blat, Sophie, Val‐Laillet, David

“…ABSTRACT This study explores the long‐term effects of exposure to a maternal Western diet (WD) vs. standard diet (SD) in the Yucatan minipig, on the adult…”
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Acceleration of Gastric Emptying by Insulin-Induced Hypoglycemia is Dependent on the Degree of Hypoglycemia by Murthy, Tejaswini Arunachala, Grivell, Jacqueline, Hatzinikolas, Seva, Chapple, Lee-anne S, Chapman, Marianne J, Stevens, Julie E, Malbert, Charles-Henri, Rayner, Christopher K, Horowitz, Michael, Jones, Karen L, Marathe, Chinmay S

“…Abstract Context Hypoglycemia is a major barrier to optimal glycemic control in insulin-treated diabetes. Recent guidelines from the American Diabetes…”
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Gastric Emptying and Dynamic In Vitro Digestion of Drinkable Yogurts: Effect of Viscosity and Composition by Ménard, Olivia, Famelart, Marie-Hélène, Deglaire, Amélie, Le Gouar, Yann, Guérin, Sylvie, Malbert, Charles-Henri, Dupont, Didier

“…Gastric emptying of food is mainly driven by the caloric concentration, the rheological properties of the chyme, and the physical state (liquid/solid) of food…”
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Effects of Chronic Consumption of Sugar-Enriched Diets on Brain Metabolism and Insulin Sensitivity in Adult Yucatan Minipigs by Ochoa, Melissa, Malbert, Charles-Henri, Meurice, Paul, Val-Laillet, David

“…Excessive sugar intake might increase the risk to develop eating disorders via an altered reward circuitry, but it remains unknown whether different sugar…”
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Chronic abdominal vagus stimulation increased brain metabolic connectivity, reduced striatal dopamine transporter and increased mid-brain serotonin transporter in obese miniature pigs by Malbert, Charles-Henri, Genissel, Mickael, Divoux, Jean-Louis, Henry, Christine

“…Changes in brain metabolism has been investigated thoroughly during unilateral cervical chronic vagal stimulation in epileptic or depressive patients…”
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Neuromodulatory and possible anxiolytic-like effects of a spice functional food ingredient in a pig model of psychosocial chronic stress by Menneson, Sophie, Ménicot, Samuel, Malbert, Charles-Henri, Meurice, Paul, Serrand, Yann, Noirot, Virginie, Etienne, Pierre, Coquery, Nicolas, Val-Laillet, David

“…[Display omitted] •The ingredient decreased anxiety-like behavior in a pig chronic stress model.•The ingredient increased expression of 5-HT1AR and BDNF in two…”
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Pancreatic GLP-1r binding potential is reduced in insulin-resistant pigs by Malbert, Charles-Henri, Chauvin, Alain, Horowitz, Michael, Jones, Karen L

“…IntroductionThe insulinotropic capacity of exogenous glucagon like peptide-1 (GLP-1) is reduced in type 2 diabetes and the insulin-resistant obese. We have…”
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Exposures to conditioned flavours with different hedonic values induce contrasted behavioural and brain responses in pigs by Clouard, Caroline, Jouhanneau, Mélanie, Meunier-Salaün, Marie-Christine, Malbert, Charles-Henri, Val-Laillet, David

“…This study investigated the behavioural and brain responses towards conditioned flavours with different hedonic values in juvenile pigs. Twelve 30-kg pigs were…”
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Open-source 3D printable frameless stereotaxic system for young and adult pigs by Malbert, Charles-Henri

“…•Brain surgery in pigs is complex limiting their use as an alternate animal model.•In-lab 3D printing of frameless stereotaxic tools could simplify porcine…”
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Dietary α‐lactalbumin supplementation alleviates normocaloric western diet‐induced glucose intolerance in Göttingen minipigs by Blat, Sophie, Vincent, Sophie, Lefeuvre, Luz, Lemoine‐Morel, Sophie, Malbert, Charles‐Henri, Pichon, Lisa, Mikogami, Takashi, Gratas‐Delamarche, Arlette

“…Objective The pandemic of obesity in Western countries is mainly due to the high‐fat, high‐energy diet prevailing there. Obesity‐associated metabolic disorders…”
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Glucose Sensing Mediated by Portal Glucagon-Like Peptide 1 Receptor Is Markedly Impaired in Insulin-Resistant Obese Animals by Malbert, Charles-Henri, Chauvin, Alain, Horowitz, Michael, Jones, Karen L

“…The glucose portal sensor informs the brain of changes in glucose inflow through vagal afferents that require an activated glucagon-like peptide 1 receptor…”
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Comparison of the efficiency of chopped and non-rectangular electrical stimulus waveforms in activating small vagus nerve fibers by Dali, Mélissa, Picq, Chloé, Rossel, Olivier, Maciejasz, Pawel, Malbert, Charles-Henri, Guiraud, David

“…•Non rectangular waveforms should be considered for long term vagus nerve stimulation.•Stimulation of duodenal neurons can be more charge efficient using ramp…”
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The Yucatan minipig model: A new preclinical model of malnutrition in obese patients with acute or chronic diseases by Couvert, Annaëlle, Lacaze, Laurence, Touboulic, Steve, Gautier, Sandrine, Guérin, Sylvie, Randuineau, Gwénaëlle, Romé, Véronique, Malbert, Charles-Henri, Val-Laillet, David, Derbré, Frédéric, Thibault, Ronan

“…Malnutrition can develop in patients with obesity suffering from acute or chronic illness or after obesity surgery, promoting sarcopenic obesity. A better…”
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