Search Results - "Malawska, B."

Multi-target-directed ligands in Alzheimer's disease treatment by Bajda, M, Guzior, N, Ignasik, M, Malawska, B

“…Among the various drug discovery methods, a very promising modern approach consists in designing multi-target-directed ligands (MTDLs). This methodology has…”
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New anticonvulsant agents by Malawska, Barbara

“…The search for antiepileptic compounds with more selective activity and lower toxicity continues to be an area of intensive investigation in medicinal…”
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Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice by Sałat, Kinga, Cios, Agnieszka, Wyska, Elżbieta, Sałat, Robert, Mogilski, Szczepan, Filipek, Barbara, Więckowski, Krzysztof, Malawska, Barbara

“…Anticancer drugs — oxaliplatin (OXPT) and paclitaxel (PACLI) cause painful peripheral neuropathy activating Transient Receptor Potential (TRP) channels. Here…”
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Search for new anticonvulsant compounds. Part 1: Synthesis, physicochemical and anticonvulsant properties of new derivatives of alpha-amino-gamma-phthalimidobutyric acid by Malawska, B, Zejc, A

“…Synthesis and physicochemical properties of new derivatives of alpha-substituted gamma-phthalimidobutyric acid are described. N-substituted amides of…”
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Synthesis, Biological Activity and Molecular Modeling of 4-Fluoro-N-[ω-(1,2,3,4-tetrahydroacridin-9-ylamino)-alkyl]-benzamide Derivatives as Cholinesterase Inhibitors by SZYMANSKI, P, MARKOWICZ, M, BAJDA, M, MALAWSKA, B, MIKICIUK-OLASIK, E

“…The aim of this study was to synthesize and determine the biological activity of new derivatives of 4-fluorobenzoic acid and tetrahydroacridine towards…”
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Analgesic, anticonvulsant and antioxidant activities of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one dihydrochloride in mice by Salat, Kinga, Moniczewski, Andrzej, Salat, Robert, Janaszek, Monika, Filipek, Barbara, Malawska, Barbara, Wieckowski, Krzysztof

“…Recently we have shown that 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one dihydrochloride (LPP1) is an antinociceptive and local…”
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Brivaracetam: a new drug in development for epilepsy and neuropathic pain by Malawska, Barbara, Kulig, Katarzyna

“…Epilepsy is a neurological disorder with a worldwide prevalence estimated to be 0.5-1.0% of the population. Many potent antiepileptic drugs (AED) have been…”
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Analgesic, antioedematous and antioxidant activity of y-butvrolactone derivatives in rodents by Salat, K, Librowski, T, Moniczewski, A, Stanisz-Wallis, K, Wieckowski, K, Malawska, B

“…In this paper, the analgesic, antioedematous, motor-impairing and antioxidant properties of four gamma -butyrolactone derivatives (BM113, BM113A, BM138 and…”
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Investigation into new anticonvulsant derivatives of α-substituted N-benzylamides of γ-hydroxy- and γ-acetoxybutyric acid. Part 5: Search for new anticonvulsant compounds by Malawska, Barbara, Kulig, Katarzyna, Śpiewak, Agnieszka, Stables, James P

“…A series of four N-benzylamides of γ-hydroxybutyric acid (GHB), that contain N-(4-phenylpiperazine)-, N-(4-benzylpiperazine)rings, N-benzylamino-, or…”
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Carisbamate, a new carbamate for the treatment of epilepsy by Kulig, Katarzyna, Malawska, Barbara

“…Carisbamate is a novel drug with neuromodulator activity that is currently under development for the treatment of epilepsy, diabetic neuropathy and neuralgia…”
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Synthesis, antiarrhythmic, and antihypertensive effects of novel 1-substituted pyrrolidin-2-one and pyrrolidine derivatives with adrenolytic activity by Malawska, Barbara, Kulig, Katarzyna, Filipek, Barbara, Sapa, Jacek, Maciąg, Dorota, Zygmunt, Małgorzata, Antkiewicz-Michaluk, Lucyna

“…A series of 1-substituted pyrrolidin-2-one and pyrrolidine derivatives were synthesised and tested for electrocardiographic, antiarrhythmic, and…”
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Estimation of the lipophilicity of antiarrhythmic and antihypertensive active 1-substituted pyrrolidin-2-one and pyrrolidine derivatives by Kulig, Katarzyna, Malawska, Barbara

“…The lipophilicity of some antiarrhythmic and antihypertensive active 1‐[2‐hydroxy‐ or 1‐[2‐acetoxy‐3‐(4‐aryl‐1‐piperazinyl)propyl]pyrrolidin‐2‐one derivatives…”
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Stereocontrolled synthesis of the enantiomers of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)-propyl]-pyrrolidin-2-one by Kulig, Katarzyna, Holzgrabe, Ulrike, Malawska, Barbara

“…The asymmetric synthesis of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)-propyl]-pyrrolidin-2-one 1 is described. Enantiomers of compound 1 were obtained using the…”
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Synthesis, physicochemical and preliminary pharmacological properties of N-[beta-hydroxy-gamma-(N-phenylpiperazinepropyl)]-2-pyrrolidinone by Malawska, B, Gorczyca, M, Filipek, B

“…The present paper reports on the synthesis and preliminary pharmacological properties of N-[beta-hydroxy-gamma-(N-phenylpiperazinepropyl)]-2- pyrrolidinone…”
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EVALUATION OF LIPOPHILICITY OF PIPERAZINE DERIVATIVES BY THIN LAYER CHROMATOGRAPHY AND PRINCIPAL COMPONENT ANALYSIS by Sârbu, C., Malawska, Barbara

“…The lipophilic character of a series of active anticonvulsant N-substituted amides of α-piperazine-γ-hydroxybutyric was studied. The classical R Mo - values…”
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Synthesis and preliminary pharmacological assessment of novel gamma-hydroxybutyric acid derivatives by Malec, D, Modzelewski, J, Malawska, B, Gorczyca, M

“…Synthesis and properties of new N-substituted amides of alpha-(1,1-ethylenedioxy)-ethyl-gamma-hydroxybutyric acid are described. The compounds were obtained by…”
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Synthesis and pharmacological properties of new N-aminoalkyl-2-pyrrolidinone derivatives by Malawska, B, Gorczyca, M, Cebo, B, Krupińska, J

“…The paper describes the mode of obtaining and physico-chemical properties of new 1-(beta-hydroxy-gamma-aminopropyl)-2-pyrrolidinone derivatives and their…”
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Synthesis and pharmacological properties of 1,3 and 5-substituted 2-pyrrolidinones by Gorczyca, M, Malawska, B, Chojnacka-Wójcik, E

“…We described synthesis of 1-aryl-3 and 5-substituted 2-pyrrolidinones (2a--5a and 3b--4b). Pharmacological studies revealed that compounds 3b, 4a and 4b have…”
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Synthesis, physicochemical properties, anticonvulsant activities and voltage-sensitive calcium channels affinity of N-substituted amides of alpha-(4-phenylpiperazino)-GABA. Part 3: Search for new anticonvulsant compounds by Malawska, B, Antkiewicz-Michaluk, L

“…This paper describes the synthesis and preliminary anticonvulsant evaluation of some GABA analogues i.e. derivatives of 2-(4-phenylpiperazino)- or…”
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Synthesis and pharmacological properties of some 2-pyrrolidinone Mannich bases by Malawska, B, Gorczyca, M, Chojnacka-Wójcik, E, Tatarczyńska, E

“…N-aminoalkyl derivatives of 2-pyrrolidinone (1-5) and methylene-bis-amino derivatives (7-9) as intermediary products formed during aminoalkylation were…”
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