Search Results - "Malathi, Krishnamurthy"

Small self-RNA generated by RNase L amplifies antiviral innate immunity by Malathi, Krishnamurthy, Dong, Beihua, Silverman, Robert H, Gale, Michael

“…Antiviral innate immunity is initiated in response to RNA molecules that are produced in virus-infected cells. These RNAs activate signalling cascades that…”
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ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections by Ramnani, Barkha, Manivannan, Praveen, Jaggernauth, Sarah, Malathi, Krishnamurthy

“…Host response to a viral infection includes the production of type I interferon (IFN) and the induction of interferon-stimulated genes that have broad…”
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RNase L Cleavage Products Promote Switch from Autophagy to Apoptosis by Caspase-Mediated Cleavage of Beclin-1 by Siddiqui, Mohammad Adnan, Mukherjee, Sushovita, Manivannan, Praveen, Malathi, Krishnamurthy

“…Autophagy and apoptosis share regulatory molecules enabling crosstalk in pathways that affect cellular homeostasis including response to viral infections and…”
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RNase L Induces Expression of A Novel Serine/Threonine Protein Kinase, DRAK1, to Promote Apoptosis by Manivannan, Praveen, Reddy, Vidita, Mukherjee, Sushovita, Clark, Kirsten Neytania, Malathi, Krishnamurthy

“…Apoptosis of virus-infected cells is an effective antiviral mechanism in addition to interferon induction to establish antiviral state to restrict virus…”
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Effect of the Viral Hemorrhagic Septicemia Virus Nonvirion Protein on Translation via PERK-eIF2α Pathway by Kesterson, Shelby Powell, Ringiesn, Jeffery, Vakharia, Vikram N, Shepherd, Brian S, Leaman, Douglas W, Malathi, Krishnamurthy

“…Viral hemorrhagic septicemia virus (VHSV) is one of the most deadly infectious fish pathogens, posing a serious threat to the aquaculture industry and…”
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RNase L Induces Autophagy via c-Jun N-terminal Kinase and Double-stranded RNA-dependent Protein Kinase Signaling Pathways by Siddiqui, Mohammad Adnan, Malathi, Krishnamurthy

“…Autophagy is a tightly regulated mechanism that mediates sequestration, degradation, and recycling of cellular proteins, organelles, and pathogens. Several…”
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Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant by Urisman, Anatoly, Molinaro, Ross J, Fischer, Nicole, Plummer, Sarah J, Casey, Graham, Klein, Eric A, Malathi, Krishnamurthy, Magi-Galluzzi, Cristina, Tubbs, Raymond R, Ganem, Don, Silverman, Robert H, DeRisi, Joseph L

“…Ribonuclease L (RNase L) is an important effector of the innate antiviral response. Mutations or variants that impair function of RNase L, particularly R462Q,…”
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Viral Hemorrhagic Septicemia Virus Activates Integrated Stress Response Pathway and Induces Stress Granules to Regulate Virus Replication by Ramnani, Barkha, Powell, Shelby, Shetty, Adarsh G, Manivannan, Praveen, Hibbard, Brian R, Leaman, Douglas W, Malathi, Krishnamurthy

“…Virus infection activates integrated stress response (ISR) and stress granule (SG) formation and viruses counteract by interfering with SG assembly, suggesting…”
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The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response by Ezelle, Heather J, Malathi, Krishnamurthy, Hassel, Bret A

“…The interferon (IFN)-regulated endoribonuclease RNase-L is involved in multiple aspects of the antimicrobial innate immune response. It is the terminal…”
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infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors by Dong, Beihua, Kim, Sanggu, Hong, Seunghee, Das Gupta, Jaydip, Malathi, Krishnamurthy, Klein, Eric A, Ganem, Don, DeRisi, Joseph L, Chow, Samson A, Silverman, Robert H

“…We recently reported identification of a previously undescribed gammaretrovirus genome, xenotropic murine leukemia virus-related virus (XMRV), in prostate…”
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Epigallocatechin-3-gallate suppresses proinflammatory cytokines and chemokines induced by Toll-like receptor 9 agonists in prostate cancer cells by Mukherjee, Sushovita, Siddiqui, Mohammad Adnan, Dayal, Shubham, Ayoub, Yasmine Zakaria, Malathi, Krishnamurthy

“…Chronic inflammation of the prostate contributes to the increased risk of prostate cancer. Microbial pathogens in the prostate cause inflammation that leads to…”
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RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells by Dayal, Shubham, Zhou, Jun, Manivannan, Praveen, Siddiqui, Mohammad Adnan, Ahmad, Omaima Farid, Clark, Matthew, Awadia, Sahezeel, Garcia-Mata, Rafael, Shemshedini, Lirim, Malathi, Krishnamurthy

“…The interferon antiviral pathways and prostate cancer genetics converge on a regulated endoribonuclease, RNase L. Positional cloning and linkage studies mapped…”
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Atypical centrioles are present in Tribolium sperm by Fishman, E. L., Jo, Kyoung, Ha, Andrew, Royfman, Rachel, Zinn, Ashtyn, Krishnamurthy, Malathi, Avidor-Reiss, Tomer

“…Typical centrioles are made of microtubules organized in ninefold symmetry. Most animal somatic cells have two centrioles for normal cell division and…”
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Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells by Molinaro, Ross J, Jha, Babal Kant, Malathi, Krishnamurthy, Varambally, Sooryanarayana, Chinnaiyan, Arul M, Silverman, Robert H

“…The antiviral and antitumor functions of RNase L are enabled by binding to the allosteric effectors 5'-phosphorylated, 2',5'-linked oligoadenylates (2-5A)…”
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RNase L interacts with Filamin A to regulate actin dynamics and barrier function for viral entry by Malathi, Krishnamurthy, Siddiqui, Mohammad Adnan, Dayal, Shubham, Naji, Merna, Ezelle, Heather J, Zeng, Chun, Zhou, Aimin, Hassel, Bret A

“…The actin cytoskeleton and its network of associated proteins constitute a physical barrier that viruses must circumvent to gain entry into cells for…”
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A comparative study of synbiotic as an add-on therapy to standard treatment in patients with aggressive periodontitis by Murugesan, Gangadevi, Sudha, Kulur, Subaramoniam, Malathi, Dutta, Trayambak, Dhanasekar, Karukkupalayam

“…Context: The role of synbiotic in the management of aggressive periodontitis (AP) is not well established. Aim: We designed this study to evaluate the efficacy…”
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A Transcriptional Signaling Pathway in the IFN System Mediated by 2'-5'-Oligoadenylate Activation of RNase L by Malathi, Krishnamurthy, Jayashree M. Paranjape, Elena Bulanova, Minsub Shim, Jeanna M. Guenther-Johnson, Pieter W. Faber, Eling, Thomas E., Bryan R. G. Williams, Silverman, Robert H.

“…Virus replication in higher vertebrates is restrained by IFNs that cause cells to transcribe genes encoding antiviral proteins, such as 2'-5' oligoadenylate…”
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Mutagenesis of the Putative Sterol-Sensing Domain of Yeast Niemann Pick C-Related Protein Reveals a Primordial Role in Subcellular Sphingolipid Distribution by Malathi, Krishnamurthy, Higaki, Katsumi, Tinkelenberg, Arthur H., Balderes, Dina A., Almanzar-Paramio, Dorca, Wilcox, Lisa J., Erdeniz, Naz, Redican, Francis, Padamsee, Mahajabeen, Liu, Ying, Khan, Sohail, Alcantara, Frederick, Carstea, Eugene D., Morris, Jill A., Sturley, Stephen L.

“…Lipid movement between organelles is a critical component of eukaryotic membrane homeostasis. Niemann Pick type C (NP-C) disease is a fatal neurodegenerative…”
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Modulatory effects by neodymium-doped yttrium aluminum garnet laser on fibroblast attachment to single rooted tooth surfaces following ultrasonic scaling and root planning: An in vitro study by Negi, Shanta, Krishnamurthy, Malathi, Ganji, Kiran Kumar, Pendor, Sunil

“…One of the most important goals of periodontal therapy is connective tissue reattachment to previously diseased root surfaces. In the recent years, laser…”
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RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules by Manivannan, Praveen, Siddiqui, Mohammad Adnan, Malathi, Krishnamurthy

“…Virus infection leads to activation of the interferon (IFN)-induced endoribonuclease RNase L, which results in degradation of viral and cellular RNAs. Both…”
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