Search Results - "Malarkey, Erik B"

Mechanisms of glutamate release from astrocytes by Malarkey, Erik B., Parpura, Vladimir

“…Astrocytes can release the excitatory transmitter glutamate which is capable of modulating activity in nearby neurons. This astrocytic glutamate release can…”
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Temporal characteristics of vesicular fusion in astrocytes: examination of synaptobrevin 2‐laden vesicles at single vesicle resolution by Malarkey, Erik B., Parpura, Vladimir

“…Non‐technical summary  Astrocytes have been shown to release transmitters by vesicle fusion, in a manner similar to that of neuronal exocytosis. The details of…”
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Ca2+ entry through TRPC1 channels contributes to intracellular Ca2+ dynamics and consequent glutamate release from rat astrocytes by Malarkey, Erik B., Ni, Yingchun, Parpura, Vladimir

“…Astrocytes can respond to a variety of stimuli by elevating their cytoplasmic Ca2+ concentration and can in turn release glutamate to signal adjacent neurons…”
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Vesicular transmitter release from astrocytes by Montana, Vedrana, Malarkey, Erik B., Verderio, Claudia, Matteoli, Michela, Parpura, Vladimir

“…Astrocytes can release a variety of transmitters, including glutamate and ATP, in response to stimuli that induce increases in intracellular Ca2+ levels. This…”
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Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice by Berbari, Nicolas F., Pasek, Raymond C., Malarkey, Erik B., Yazdi, S. M. Zaki, McNair, Andrew D., Lewis, Wesley R., Nagy, Tim R., Kesterson, Robert A., Yoder, Bradley K.

“…Although primary cilia are well established as important sensory and signaling structures, their function in most tissues remains unknown. Obesity is a feature…”
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Levetiracetam reverses synaptic deficits produced by overexpression of SV2A by Nowack, Amy, Malarkey, Erik B, Yao, Jia, Bleckert, Adam, Hill, Jessica, Bajjalieh, Sandra M

“…Levetiracetam is an FDA-approved drug used to treat epilepsy and other disorders of the nervous system. Although it is known that levetiracetam binds the…”
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Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons by Ni, Yingchun, Malarkey, Erik B, Parpura, Vladimir

“…The major excitatory neurotransmitter in the CNS, glutamate, can be released exocytotically by neurons and astrocytes. Glutamate released from neurons can…”
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Hippocampal and cortical primary cilia are required for aversive memory in mice by Berbari, Nicolas F, Malarkey, Erik B, Yazdi, S M Zaki R, McNair, Andrew D, Kippe, Jordyn M, Croyle, Mandy J, Kraft, Timothy W, Yoder, Bradley K

“…It has been known for decades that neurons throughout the brain possess solitary, immotile, microtubule based appendages called primary cilia. Only recently…”
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Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease by Lewis, Wesley R, Malarkey, Erik B, Tritschler, Douglas, Bower, Raqual, Pasek, Raymond C, Porath, Jonathan D, Birket, Susan E, Saunier, Sophie, Antignac, Corinne, Knowles, Michael R, Leigh, Margaret W, Zariwala, Maimoona A, Challa, Anil K, Kesterson, Robert A, Rowe, Steven M, Drummond, Iain A, Parant, John M, Hildebrandt, Friedhelm, Porter, Mary E, Yoder, Bradley K, Berbari, Nicolas F

“…Ciliopathies are genetic disorders arising from dysfunction of microtubule-based cellular appendages called cilia. Different cilia types possess distinct…”
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KIAA0556 is a novel ciliary basal body component mutated in Joubert syndrome by Sanders, Anna A W M, de Vrieze, Erik, Alazami, Anas M, Alzahrani, Fatema, Malarkey, Erik B, Sorusch, Nasrin, Tebbe, Lars, Kuhns, Stefanie, van Dam, Teunis J P, Alhashem, Amal, Tabarki, Brahim, Lu, Qianhao, Lambacher, Nils J, Kennedy, Julie E, Bowie, Rachel V, Hetterschijt, Lisette, van Beersum, Sylvia, van Reeuwijk, Jeroen, Boldt, Karsten, Kremer, Hannie, Kesterson, Robert A, Monies, Dorota, Abouelhoda, Mohamed, Roepman, Ronald, Huynen, Martijn H, Ueffing, Marius, Russell, Rob B, Wolfrum, Uwe, Yoder, Bradley K, van Wijk, Erwin, Alkuraya, Fowzan S, Blacque, Oliver E

“…Joubert syndrome (JBTS) and related disorders are defined by cerebellar malformation (molar tooth sign), together with neurological symptoms of variable…”
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Proximal Tubule Proliferation Is Insufficient to Induce Rapid Cyst Formation after Cilia Disruption by SHARMA, Neeraj, MALARKEY, Erik B, BERBARI, Nicolas F, O'CONNOR, Amber K, VANDEN HEUVEL, Gregory B, MRUG, Michal, YODER, Bradley K

“…Disrupting the function of cilia in mouse kidneys results in rapid or slow progression of cystic disease depending on whether the animals are juveniles or…”
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Applications of carbon nanotubes in neurobiology by Malarkey, Erik B, Parpura, Vladimir

“…Carbon nanotubes are one of the most promising materials for the electronics, computer and aerospace industries. There are numerous properties of carbon…”
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Role of epidermal primary cilia in the homeostasis of skin and hair follicles by Croyle, Mandy J, Lehman, Jonathan M, O'Connor, Amber K, Wong, Sunny Y, Malarkey, Erik B, Iribarne, Daniela, Dowdle, William E, Schoeb, Trenton R, Verney, Zoe M, Athar, Mohammad, Michaud, Edward J, Reiter, Jeremy F, Yoder, Bradley K

“…Skin and hair follicle morphogenesis and homeostasis require the integration of multiple signaling pathways, including Hedgehog (Hh) and Wingless (Wnt), and…”
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A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4 by Masyukova, Svetlana V, Landis, Dawn E, Henke, Scott J, Williams, Corey L, Pieczynski, Jay N, Roszczynialski, Kelly N, Covington, Jannese E, Malarkey, Erik B, Yoder, Bradley K

“…Nephronophthisis (NPHP) is a ciliopathy in which genetic modifiers may underlie the variable penetrance of clinical features. To identify modifiers, a screen…”
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Chemically functionalized water soluble single-walled carbon nanotubes modulate neurite outgrowth by Ni, Yingchun, Hu, Hui, Malarkey, Erik B, Zhao, Bin, Montana, Vedrana, Haddon, Robert C, Parpura, Vladimir

“…We report the use of chemically-functionalized water soluble single-walled carbon nanotube (SWNT) graft copolymers for modulation of outgrowth of neuronal…”
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An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue by O'Connor, Amber K, Malarkey, Erik B, Berbari, Nicolas F, Croyle, Mandy J, Haycraft, Courtney J, Bell, P Darwin, Hohenstein, Peter, Kesterson, Robert A, Yoder, Bradley K

“…Cilia are found on nearly every cell type in the mammalian body, and have been historically classified as either motile or immotile. Motile cilia are important…”
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Dynamic imaging of cannabinoid receptor 1 vesicular trafficking in cultured astrocytes by Osborne, Kyle D, Lee, William, Malarkey, Erik B, Irving, Andrew J, Parpura, Vladimir

“…Astrocytes possess GPCRs (G-protein-coupled receptors) for neuroactive substances and can respond via these receptors to signals originating from neurons as…”
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Conductive Single-Walled Carbon Nanotube Substrates Modulate Neuronal Growth by Malarkey, Erik B, Fisher, Kirk A, Bekyarova, Elena, Liu, Wei, Haddon, Robert C, Parpura, Vladimir

“…We used conductive nanotube films as substrates with which we could systematically vary the conductance to see how this property affects neuronal growth. Here…”
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Carbon nanotubes in neuroscience by Malarkey, Erik B, Parpura, Vladimir

“…Carbon nanotubes have electrical, mechanical and chemical properties that make them one of the most promising materials for applications in neuroscience…”
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Mks6 mutations reveal tissue‐ and cell type‐specific roles for the cilia transition zone by Lewis, Wesley R., Bales, Katie L., Revell, Dustin Z., Croyle, Mandy J., Engle, Staci E., Song, Cheng Jack, Malarkey, Erik B., Uytingco, Cedric R., Shan, Dan, Antonellis, Patrick J., Nagy, Tim R., Kesterson, Robert A., Mrug, Michal M., Martens, Jeffrey R., Berbari, Nicolas F., Gross, Alecia K., Yoder, Bradley K.

“…ABSTRACT The transition zone (TZ) is a domain at the base of the cilium that is involved in maintaining ciliary compartment‐specific sensory and signaling…”
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