A Broad Role for the Zinc Finger Protein ZNF202 in Human Lipid Metabolism

The ZNF202 gene resides in a chromosomal region linked genetically to low high density lipoprotein cholesterol in Utah families. Here we show that the ZNF202 gene product is a transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among it...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 275; no. 21; pp. 15685 - 15690
Main Authors:	Wagner, Susanne, Hess, Mark A., Ormonde-Hanson, Patricia, Malandro, Jennifer, Hu, Heping, Chen, Mike, Kehrer, Robert, Frodsham, Michael, Schumacher, Christoph, Beluch, Michael, Honer, Christian, Skolnick, Mark, Ballinger, Dennis, Bowen, Benjamin R.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 26-05-2000 American Society for Biochemistry and Molecular Biology
Subjects:	Alternative Splicing - genetics apolipoprotein AIV apolipoprotein CIII Apolipoproteins - metabolism Binding Sites Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line Chromosome Mapping Chromosomes, Human, Pair 11 Databases, Factual DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation Genetic Linkage Humans Hyperlipidemias - etiology Hyperlipidemias - genetics lecithin cholesteryl ester transferase Lipid Metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Sequence Alignment Transcription Factors - genetics Transcription Factors - metabolism Utah Zinc Fingers - genetics ZNF202 gene ZNF202 protein Utah
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Summary:	The ZNF202 gene resides in a chromosomal region linked genetically to low high density lipoprotein cholesterol in Utah families. Here we show that the ZNF202 gene product is a transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), and several genes involved in processes related to energy metabolism and vascular disease. Based on the linkage and apparent transcriptional function of ZNF202, we propose that ZNF202 is a candidate susceptibility gene for human dyslipidemia.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0021-9258 1083-351X
DOI:	10.1074/jbc.M910152199