Search Results - "Malalasekera, Aruni P."

A Nanobiosensor for the Detection of Arginase Activity by Malalasekera, Aruni P., PhD, Wang, Hongwang, PhD, Samarakoon, Thilani N., PhD, Udukala, Dinusha N., PhD, Yapa, Asanka S, Ortega, Raquel, Shrestha, Tej B., PhD, Alshetaiwi, Hamad, McLaurin, Emily J., PhD, Troyer, Deryl L., PhD, Bossmann, Stefan H., PhD

“…Abstract A nanobiosensor for arginase detection was designed and synthesized. It features a central dopamine-coated iron/iron oxide nanoparticle to which…”
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Pyrazolyl Thioureas and Carbothioamides with an NNSN Motif against MSSA and MRSA by Delpe-Acharige, Anjana, Zhang, Man, Eschliman, Kayla, Dalecki, Alex, Covarrubias-Zambrano, Obdulia, Minjarez-Almeida, Azriel, Shrestha, Tejaswi, Lewis, Tanji, Al-Ibrahim, Fatimah, Leonard, Sophia, Roberts, Riana, Tebeje, Anteneh, Malalasekera, Aruni P, Wang, Hongwang, Kalubowilage, Madumali, Wolschendorf, Frank, Kutsch, Olaf, Bossmann, Stefan H

“…A novel series of copper-activatable drugs intended for use against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus…”
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Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection by Udukala, Dinusha N, Wang, Hongwang, Wendel, Sebastian O, Malalasekera, Aruni P, Samarakoon, Thilani N, Yapa, Asanka S, Abayaweera, Gayani, Basel, Matthew T, Maynez, Pamela, Ortega, Raquel, Toledo, Yubisela, Bossmann, Leonie, Robinson, Colette, Janik, Katharine E, Koper, Olga B, Li, Ping, Motamedi, Massoud, Higgins, Daniel A, Gadbury, Gary, Zhu, Gaohong, Troyer, Deryl L, Bossmann, Stefan H

“…Proteases, including matrix metalloproteinases (MMPs), tissue serine proteases, and cathepsins (CTS) exhibit numerous functions in tumor biology. Solid tumors…”
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Synergy of Iron Chelators and Therapeutic Peptide Sequences Delivered via a Magnetic Nanocarrier by Abayaweera, Gayani S, Wang, Hongwang, Shrestha, Tej B, Yu, Jing, Angle, Kyle, Thapa, Prem, Malalasekera, Aruni P, Maurmann, Leila, Troyer, Deryl L, Bossmann, Stefan H

“…Here, we report the synthesis, characterization, and efficacy study of Fe/Fe₃O₄-nanoparticles that were co-labeled with a tumor-homing and membrane-disrupting…”
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8-Hydroxyquinolines Are Boosting Agents of Copper-Related Toxicity in Mycobacterium tuberculosis by Shah, Santosh, Dalecki, Alex G, Malalasekera, Aruni P, Crawford, Cameron L, Michalek, Suzanne M, Kutsch, Olaf, Sun, Jim, Bossmann, Stefan H, Wolschendorf, Frank

“…Copper (Cu) ions are likely the most important immunological metal-related toxin utilized in controlling bacterial infections. Impairment of bacterial Cu…”
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Optical biosensing of markers of mucosal inflammation by Covarrubias-Zambrano, Obdulia, Motamedi, Massoud, Ameredes, Bill T., Tian, Bing, Calhoun, William J., Zhao, Yingxin, Brasier, Allan R., Kalubowilage, Madumali, Malalasekera, Aruni P., Yapa, Asanka S., Wang, Hongwang, Culbertson, Christopher T., Troyer, Deryl L., Bossmann, Stefan H.

“…We report the design and adaptation of iron/iron oxide nanoparticle-based optical nanobiosensors for enzymes or cytokine/chemokines that are established…”
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Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors by Kalubowilage, Madumali, Covarrubias-Zambrano, Obdulia, Malalasekera, Aruni P., Wendel, Sebastian O., Wang, Hongwang, Yapa, Asanka S., Chlebanowski, Lauren, Toledo, Yubisela, Ortega, Raquel, Janik, Katharine E., Shrestha, Tej B., Culbertson, Christopher T., Kasi, Anup, Williamson, Stephen, Troyer, Deryl L., Bossmann, Stefan H.

“…Numerous proteases, such as matrix metalloproteinases (MMPs), cathepsins (CTS), and urokinase plasminogen activator (UpA), are dysfunctional (that is, over- or…”
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Insights from Theory and Experiment on the Photochromic spiro-Dihydropyrrolo–Pyridazine/Betaine System by Fernando, Amendra, Shrestha, Tej B, Liu, Yao, Malalasekera, Aruni P, Yu, Jing, McLaurin, Emily J, Turro, Claudia, Bossmann, Stefan H, Aikens, Christine M

“…We elucidated the photochromic spiro-4a,5-dihydropyrrolo­[1,2-b]­pyridazine/betaine (DPP/betaine) system by comparing state-of-the-art density functional…”
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Refined Insights in the Photochromic spiro-Dihydroindolizine/Betaine System by Fernando, Amendra, Malalasekera, Aruni P, Yu, Jing, Shrestha, Tej B, McLaurin, Emily J, Bossmann, Stefan H, Aikens, Christine M

“…We have revisited the photochromic spiro-dihydroindolizine/betaine system by comparing state-of-the-art density functional theory calculations with…”
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Combinatorial phenotypic screen uncovers unrecognized family of extended thiourea inhibitors with copper-dependent anti-staphylococcal activity by Dalecki, Alex G, Malalasekera, Aruni P, Schaaf, Kaitlyn, Kutsch, Olaf, Bossmann, Stefan H, Wolschendorf, Frank

“…The continuous rise of multi-drug resistant pathogenic bacteria has become a significant challenge for the health care system. In particular, novel drugs to…”
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Rationally designed peptide nanosponges for cell-based cancer therapy by Wang, Hongwang, Yapa, Asanka S., Kariyawasam, Nilusha L., Shrestha, Tej B., Kalubowilage, Madumali, Wendel, Sebastian O., Yu, Jing, Pyle, Marla, Basel, Matthew T., Malalasekera, Aruni P., Toledo, Yubisela, Ortega, Raquel, Thapa, Prem S., Huang, Hongzhou, Sun, Susan X., Smith, Paul E., Troyer, Deryl L., Bossmann, Stefan H.

“…A novel type of supramolecular aggregate, named a “nanosponge” was synthesized through the interaction of novel supramolecular building blocks with trigonal…”
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Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cells by Yapa, Asanka S, Wang, Hongwang, Wendel, Sebastian O, Shrestha, Tej B, Kariyawasam, Nilusha L, Kalubowilage, Madumali, Perera, Ayomi S, Pyle, Marla, Basel, Matthew T, Malalasekera, Aruni P, Manawadu, Harshi, Yu, Jing, Toledo, Yubisela, Ortega, Raquel, Thapa, Prem S, Smith, Paul E, Troyer, Deryl L, Bossmann, Stefan H

“…The structure of novel binary nanosponges consisting of (cholesterol-(K/D) DEVDGC) -trimaleimide units possessing a trigonal maleimide linker, to which either…”
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Peptide Nanosponges Designed for the Delivery of Perillyl Alcohol to Glioma Cells by Yapa, Asanka S, Shrestha, Tej B, Wendel, Sebastian O, Kalubowilage, Madumali, Yu, Jing, Wang, Hongwang, Pyle, Marla, Basel, Matthew T, Toledo, Yubisela, Ortega, Raquel, Malalasekera, Aruni P, Thapa, Prem S, Troyer, Deryl L, Bossmann, Stefan H

“…Peptide nanosponges of low polydispersity are spontaneously formed from trigonal supramolecular building blocks in aqueous buffers, which feature cationic…”
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Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cellsElectronic supplementary information (ESI) available: Supporting Information is available free of charge on the RSC Advances website. It contains the chemical structure of 5(6) carboxy-fluorescein (CF), as well as its excitation and emission spectrum, the calibration curve for measuring CF fluorescence vs. concentration, and the DLS characterization of the DK20 nanosponges. An estimation of the number of CF molecule by Yapa, Asanka S, Wang, Hongwang, Wendel, Sebastian O, Shrestha, Tej. B, Kariyawasam, Nilusha L, Kalubowilage, Madumali, Perera, Ayomi S, Pyle, Marla, Basel, Matthew T, Malalasekera, Aruni P, Manawadu, Harshi, Yu, Jing, Toledo, Yubisela, Ortega, Raquel, Thapa, Prem S, Smith, Paul E, Troyer, Deryl L, Bossmann, Stefan H

“…The structure of novel binary nanosponges consisting of (cholesterol-(K/D) n DEVDGC) 3 -trimaleimide units possessing a trigonal maleimide linker, to which…”
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