Search Results - "Malacarne, Pedro F."
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Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling
Published in Frontiers in physiology (02-12-2022)“…The cytochrome P450 reductase (POR) transfers electrons to all microsomal cytochrome P450 enzymes (CYP450) thereby driving their activity. In the vascular…”
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A review on the Scorpaena plumieri fish venom and its bioactive compounds
Published in The journal of venomous animals and toxins including tropical diseases (21-12-2016)“…The most poisonous fish species found along the Brazilian coast is the spotted scorpionfish . Though hardly ever life-threatening to humans, envenomation by…”
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Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases
Published in British journal of pharmacology (01-04-2021)“…Background and Purpose Organic nitrates such as nitroglycerin (NTG) or pentaerythritol tetranitrate (PETN) have been used for over a century in the treatment…”
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Advances in the characterization of the Scorpaena plumieri cytolytic toxin (Sp-CTx)
Published in Toxicon (Oxford) (01-08-2018)“…Proteins that account for the hemolytic activity found in scorpaeniform fish venoms are responsible for the majority of the effects observed upon envenomation,…”
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Cardiovascular effects of Sp-CTx, a cytolysin from the scorpionfish (Scorpaena plumieri) venom
Published in Toxicon (Oxford) (01-08-2016)“…Fish venom cytolysins are multifunctional proteins that in addition to their cytolytic/hemolytic effects display neurotoxic, cardiotoxic and inflammatory…”
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Abstract P2041: Cytochrome P450 Reductase Prevents Cardiac Hypertrophy Through Crosstalk
Published in Circulation research (05-08-2022)“…The cytochrome P450 reductase (POR) transfers electrons and thus drives the function of all cytochrome P450-dependent enzymes (CYP450). In the vascular system,…”
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Endothelial Cytochrome P450 Reductase-Derived Cholesterol Limits Angiogenesis
Published in Free radical biology & medicine (01-11-2023)Get full text
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Impaired complex I repair causes recessive Leber's hereditary optic neuropathy
Published in The Journal of clinical investigation (15-03-2021)“…Leber's hereditary optic neuropathy (LHON) is the most frequent mitochondrial disease and was the first to be genetically defined by a point mutation in…”
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Abstract 12226: Aging Impairs the Neuro-Vascular Interface in the Heart
Published in Circulation (New York, N.Y.) (07-11-2023)“…Abstract only Aging is a major risk factor for impaired cardiovascular function. The aging heart is characterized by vascular dysfunction, increased…”
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