Search Results - "Malčíková, J"

Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2 by Strefford, J C, Sutton, L-A, Baliakas, P, Agathangelidis, A, Malčíková, J, Plevova, K, Scarfó, L, Davis, Z, Stalika, E, Cortese, D, Cahill, N, Pedersen, L B, di Celle, P F, Tzenou, T, Geisler, C, Panagiotidis, P, Langerak, A W, Chiorazzi, N, Pospisilova, S, Oscier, D, Davi, F, Belessi, C, Mansouri, L, Ghia, P, Stamatopoulos, K, Rosenquist, R

“…Recent studies have revealed recurrent mutations of the NOTCH1 , SF3B1 and BIRC3 genes in chronic lymphocytic leukemia (CLL), especially among aggressive,…”
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Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia by Malcikova, J, Stano-Kozubik, K, Tichy, B, Kantorova, B, Pavlova, S, Tom, N, Radova, L, Smardova, J, Pardy, F, Doubek, M, Brychtova, Y, Mraz, M, Plevova, K, Diviskova, E, Oltova, A, Mayer, J, Pospisilova, S, Trbusek, M

“…In chronic lymphocytic leukemia (CLL), the worst prognosis is associated with TP53 defects with the affected patients being potentially directed to alternative…”
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ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretation by Malcikova, J., Tausch, E., Rossi, D., Sutton, L. A., Soussi, T., Zenz, T., Kater, A. P., Niemann, C. U., Gonzalez, D., Davi, F., Gonzalez Diaz, M., Moreno, C., Gaidano, G., Stamatopoulos, K., Rosenquist, R., Stilgenbauer, S., Ghia, P., Pospisilova, S.

“…In chronic lymphocytic leukemia (CLL), TP53 gene defects, due to deletion of the 17p13 locus and/or mutation(s) within the TP53 gene, are associated with…”
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Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status by Kubesova, B, Pavlova, S, Malcikova, J, Kabathova, J, Radova, L, Tom, N, Tichy, B, Plevova, K, Kantorova, B, Fiedorova, K, Slavikova, M, Bystry, V, Kissova, J, Gisslinger, B, Gisslinger, H, Penka, M, Mayer, J, Kralovics, R, Pospisilova, S, Doubek, M

“…The multistep process of TP53 mutation expansion during myeloproliferative neoplasm (MPN) transformation into acute myeloid leukemia (AML) has been documented…”
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ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia by Pospisilova, S, Gonzalez, D, Malcikova, J, Trbusek, M, Rossi, D, Kater, A P, Cymbalista, F, Eichhorst, B, Hallek, M, Döhner, H, Hillmen, P, van Oers, M, Gribben, J, Ghia, P, Montserrat, E, Stilgenbauer, S, Zenz, T

“…Recent evidence suggests that – in addition to 17p deletion – TP53 mutation is an independent prognostic factor in chronic lymphocytic leukemia (CLL). Data…”
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The impact of SF3B1 mutations in CLL on the DNA-damage response by te Raa, G D, Derks, I A M, Navrkalova, V, Skowronska, A, Moerland, P D, van Laar, J, Oldreive, C, Monsuur, H, Trbusek, M, Malcikova, J, Lodén, M, Geisler, C H, Hüllein, J, Jethwa, A, Zenz, T, Pospisilova, S, Stankovic, T, van Oers, M H J, Kater, A P, Eldering, E

“…Mutations or deletions in TP53 or ATM are well-known determinants of poor prognosis in chronic lymphocytic leukemia (CLL), but only account for approximately…”
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Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting by Sutton, Lesley-Ann, Ljungström, Viktor, Mansouri, Larry, Young, Emma, Cortese, Diego, Navrkalova, Veronika, Malcikova, Jitka, Muggen, Alice F, Trbusek, Martin, Panagiotidis, Panagiotis, Davi, Frederic, Belessi, Chrysoula, Langerak, Anton W, Ghia, Paolo, Pospisilova, Sarka, Stamatopoulos, Kostas, Rosenquist, Richard

“…Next-generation sequencing has revealed novel recurrent mutations in chronic lymphocytic leukemia, particularly in patients with aggressive disease. Here, we…”
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miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities by Mraz, M, Malinova, K, Kotaskova, J, Pavlova, S, Tichy, B, Malcikova, J, Stano Kozubik, K, Smardova, J, Brychtova, Y, Doubek, M, Trbusek, M, Mayer, J, Pospisilova, S

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Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL by Brazdilova, K, Plevova, K, Skuhrova Francova, H, Kockova, H, Borsky, M, Bikos, V, Malcikova, J, Oltova, A, Kotaskova, J, Tichy, B, Brychtova, Y, Mayer, J, Doubek, M, Pospisilova, S

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TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations by Zenz, T, Vollmer, D, Trbusek, M, Smardova, J, Benner, A, Soussi, T, Helfrich, H, Heuberger, M, Hoth, P, Fuge, M, Denzel, T, Häbe, S, Malcikova, J, Kuglik, P, Truong, S, Patten, N, Wu, L, Oscier, D, Ibbotson, R, Gardiner, A, Tracy, I, Lin, K, Pettitt, A, Pospisilova, S, Mayer, J, Hallek, M, Döhner, H, Stilgenbauer, S

“…The TP53 mutation profile in chronic lymphocytic leukemia (CLL) and the correlation of TP53 mutations with allele status or associated molecular genetics are…”
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Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go? by Pospisilova, Sarka, Sutton, Lesley-Ann, Malcikova, Jitka, Tausch, Eugen, Rossi, Davide, Montserrat, Emili, Moreno, Carol, Stamatopoulos, Kostas, Gaidano, Gianluca, Rosenquist, Richard, Ghia, Paolo

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P614: SUBCLONAL ARCHITECTURE OF CHROMOSOMES REVEALED BY SINGLE‐CELL ANALYSIS OF GENE EXPRESSION IN A PATIENT WITH CLONAL EVOLUTION OF RELAPSING/REFRACTORY CLL by Kotaskova, J., Kurucova, T., Reblova, K., Valisova, M., Zavacka, K., Mareckova, A., Bohunova, M., Pavlova, S., Malcikova, J., Navrkalova, V., Jarosova, M., Doubek, M., Plevova, K., Pospisilova, S.

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P608: DISTINCT P53 PHOSPHORYLATION PATTERNS IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS ARE REFLECTED IN CIRCUMJACENT PATHWAYS’ ACTIVATION UPON DNA DAMAGE by Pesova, M., Mancikova, V., Helma, R., Pavlova, S., Hejret, V., Taus, P., Hynst, J., Plevova, K., Kotaskova, J., Malcikova, J., Pospisilova, S.

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885 P53 Mutations Affecting DNA-binding Have Prominent Impact on Survival in Chronic Lymphocytic Leukemia by Malcikova, J, Smardova, J, Sebejova, L, Vranova, V, Pavlova, S, Doubek, M, Brychtova, Y, Pospisilova, S, Mayer, J, Trbusek, M

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613 Clonal Selection of TP53 Mutations in Chronic Lymphocytic Leukaemia Detected by Ultra-deep Pyrosequencing by Kozubik, K. Stano, Malcikova, J, Trbusek, M, Tom, N, Doubek, M, Brychtova, Y, Smardova, J, Mayer, J, Pospisilova, S, Tichy, B

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Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation status and previous treatment by Trbusek, M, Malcikova, J, Smardova, J, Kuhrova, V, Mentzlova, D, Francova, H, Bukovska, S, Svitakova, M, Kuglik, P, Linkova, V, Doubek, M, Brychtova, Y, Zacal, J, Kujickova, J, Pospisilova, S, Dvorakova, D, Vorlicek, J, Mayer, J

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Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia by Malcikova, J., Smardova, J., Pekova, S., Cejkova, S., Kotaskova, J., Tichy, B., Francova, H., Doubek, M., Brychtova, Y., Janek, D., Pospisilova, S., Mayer, J., Dvorakova, D., Trbusek, M.

“…Abnormalities of the TP53 gene are associated with a particularly severe prognosis in patients with B-cell chronic lymphocytic leukemia (B-CLL). This…”
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1.8 MicroRNA Mutational Analysis in Patients with Chronic Lymphocytic Leukemia by Lochmanova, J, Navrkalova, V, Dvorakova, B, Mraz, M, Pavlova, S, Plevova, K, Tichy, B, Malcikova, J, Sebejova, L, Benes, V, Rausch, T, Brychtova, Y, Doubek, M, Trbusek, M, Mayer, J, Pospisilova, S

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666 Analysis of microRNAs associated with aggressive subtype of chronic lymphocytic leukaemia harbouring inactivated p53 by Pavlova, S, Mraz, M, Plevova, K, Tvaruzkova, Z, Malcikova, J, Trbusek, M, Brychtova, Y, Doubek, M, Mayer, J, Pospisilova, S

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159 Selection and clinical relevance of monoallelic and biallelic TP53 defects in chronic lymphocytic leukemia by Malcikova, J, Trbusek, M, Smardova, J, Rocnova, L, Tichy, B, Kuglik, P, Brychtova, Y, Doubek, M, Mayer, J, Pospisilova, S

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