Search Results - "Maláková, Jana"

In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity by ADAMCOVA, Michaela, SIMUNEK, Tomas, KAISEROVA, Helena, POPELOVA, Olga, STERBA, Martin, POTACOVA, Anna, VAVROVA, Jaroslava, MALAKOVA, Jana, GERSL, Vladimir

“…Abstract Cardiac troponin T (cTnT) and troponin I (cTnI) are becoming acknowledged as useful biochemical markers of drug-induced cardiotoxicity. In this study…”
Get full text

Behavioral effects of antiepileptic drugs in rats: Are the effects on mood and behavior detectable in open-field test? by Zimcikova, Eva, Simko, Julius, Karesova, Iva, Kremlacek, Jan, Malakova, Jana

“…•Antiepileptic drugs (AEDs) are often associated with behavioral side effects.•Animal models can help to predict the impact of AEDs on mood, anxiety and…”
Get full text

Allogeneic Bone Impregnated with Biodegradable Depot Delivery Systems for the Local Treatment of Joint Replacement Infections: An In Vitro Study by Prokes, Libor, Snejdrova, Eva, Soukup, Tomas, Malakova, Jana, Frolov, Vladislav, Loskot, Jan, Andrys, Rudolf, Kucera, Tomas

“…Although progress is evident in the effective treatment of joint replacement-related infections, it still remains a serious issue in orthopedics. As an…”
Get full text

Plasmafiltration as an effective method in the removal of circulating pegylated liposomal doxorubicin (PLD) and the reduction of mucocutaneous toxicity during the treatment of advanced platinum-resistant ovarian cancer by Kubeček, Ondřej, Martínková, Jiřina, Chládek, Jaroslav, Bláha, Milan, Maláková, Jana, Hodek, Miroslav, Špaček, Jiří, Filip, Stanislav

“…Purpose The present study evaluates the safety and efficacy of double-plasma filtration (PF) to remove the exceeding pegylated liposomal doxorubicin (PLD) in…”
Get full text

Is it possible to shorten serum bactericidal testing? by Pavla, Paterova, Jakub, Radocha, Vladimir, Buchta, Alzbeta, Zavrelova, Jana, Malakova, Pavel, Zak, Helena, Zemlickova

“…Serum bactericidal test represents an alternative possibility for optimization of antibiotic treatment. The paper aimed to confirm non-inferiority of…”
Get full text

Elution kinetics of vancomycin and gentamicin from carriers and their effects on mesenchymal stem cell proliferation: an in vitro study by Kucera, Tomas, Ryskova, Lenka, Soukup, Tomas, Malakova, Jana, Cermakova, Eva, Mericka, Pavel, Suchanek, Jakub, Sponer, Pavel

“…Musculoskeletal infections remain a major complication in orthopedic surgery. The local delivery of antibiotics provides the high levels required to treat an…”
Get full text

The significance of enzyme and transporter polymorphisms for imatinib plasma levels and achieving an optimal response in chronic myeloid leukemia patients by Belohlavkova, Petra, Vrbacky, Filip, Voglova, Jaroslava, Racil, Zdenek, Zackova, Daniela, Hrochova, Katerina, Malakova, Jana, Mayer, Jiri, Zak, Pavel

“…Imatinib mesylate is the drug of choice for patients with chronic myeloid leukemia (CML). Imatinib pharmacokinetics is affected by a number of transport…”
Get full text

Plasmafiltration as a possible contributor to kinetic targeting of pegylated liposomal doxorubicin (PLD) in order to prevent organ toxicity and immunosuppression by Martínková, Jiřina, Bláha, Milan, Kubeček, Ondřej, Maláková, Jana, Špaček, Jiří, Bezouška, Jan, Krulichová, Iva Selke, Filip, Stanislav

“…Purpose To examine the removal of pegylated liposomal doxorubicin (PLD) during plasmafiltration (PF) and determine whether the drug could be withheld prior to…”
Get full text

New high-performance liquid chromatography method for the determination of ( R)-warfarin and ( S)-warfarin using chiral separation on a glycopeptide-based stationary phase by Malakova, Jana, Pavek, Petr, Svecova, Lucie, Jokesova, Iveta, Zivny, Pavel, Palicka, Vladimir

“…Warfarin is a well-known anticoagulant agent that occurs in two enantiomers, ( R)-(+)-warfarin and ( S)-(−)-warfarin. A new liquid chromatography method for…”
Get full text

High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samples by Maláková, Jana, Nobilis, Milan, Svoboda, Zbyněk, Lísa, Miroslav, Holčapek, Michal, Květina, Jaroslav, Klimeš, Jiří, Palička, Vladimír

“…Galantamine, an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii, Amaryllidaceae) and related species, is employed in…”
Get full text

Lack of Interactions between Breast Cancer Resistance Protein (BCRP/ABCG2) and Selected Antiepileptic Agents by Cerveny, Lukas, Pavek, Petr, Malakova, Jana, Staud, Frantisek, Fendrich, Zdenek

“…Purpose: Recent studies have indicated constitutive expression of efflux transporter, breast cancer resistance protein (BCRP, ABCG2), in endothelial cells of…”
Get full text

The effect of lacosamide on bone tissue in orchidectomised male albino Wistar rats by Simko, Julius, Fekete, Sona, Malakova, Jana, Kremlacek, Jan, Horacek, Jiri, Zivna, Helena, Palicka, Vladimir, Zivny, Pavel

“…While most antiepileptic drugs (AEDs) have been associated with various adverse effects on bone health, for the recently introduced lacosamide (LCM) no…”
Get full text

Up-regulation of renal Mdr1 and Mrp2 transporters during amiodarone pretreatment in rats by Cermanova, Jolana, Fuksa, Leos, Brcakova, Eva, Hroch, Milos, Kucera, Otto, Kolouchova, Gabriela, Hirsova, Petra, Malakova, Jana, Staud, Frantisek, Martinkova, Jirina, Cervinkova, Zuzana, Micuda, Stanislav

“…Although amiodarone (AMD) is known to produce drug–drug interactions through inhibition of transporter-mediated excretion of drugs, its impact on these…”
Get full text

Pharmacokinetics and organ distribution of fluorescein in experimental pigs: an input study for confocal laser endomicroscopy of the gastrointestinal tract by Kunes, Martin, Kvetina, Jaroslav, Malakova, Jana, Bures, Jan, Kopacova, Marcela, Rejchrt, Stanislav

“…Confocal laser scanning endomicroscopy (CLSE) is a diagnostic technology that produces virtual histology of the mucosal layer using fluorescence technique…”
Get more information

Influence of CYP3A metabolizer status on the pharmacokinetics and pharmacodynamics of amiodarone by Micuda, S, Hodac, M, Parízek, P, Pleskot, M, Sispera, L, Cerman, J, Maláková, J, Martínková, J, Pidrman, V

“…The present work was designed to determine whether the individual differences in pharmacokinetics and pharmacodynamics of amiodarone and its N-desethyl…”
Get full text

Dynamics of the vitamin D C3-epimer levels in preterm infants by Matejek, Tomas, Zapletalova, Bara, Stepan, Martin, Malakova, Jana, Palicka, Vladimir

“…The primary objective was to determine levels of C3-epi-25(OH)D in very low birth weight infants. The secondary objective was to evaluate the possible…”
Get more information

Severe vitamin D deficiency in preterm infants: possibly no association with clinical outcomes? by Matejek, Tomas, Zemankova, Jana, Malakova, Jana, Cermakova, Eva, Skalova, Sylva, Palicka, Vladimir

“…The primary objective of this study was to compare clinical outcomes of very low birth weight (VLBW) infants with 25-hydroxy vitamin D [25(OH)D] levels <25…”
Get full text

Superiority of ceftazidime off‐label high‐dose regimen in PK/PD target attainment during treatment of extensively drug‐resistant Pseudomonas aeruginosa infections in cancer patients by Zavrelova, Alzbeta, Sima, Martin, Malakova, Jana, Rozsivalova, Petra, Paterova, Pavla, Zak, Pavel, Visek, Benjamin, Michalickova, Danica, Slanar, Ondrej, Radocha, Jakub

“…Aim The objective of this study was to evaluate off‐label high‐dose ceftazidime population pharmacokinetics in cancer patients with suspected or proven…”
Get full text

The Effect of Zonisamide on Rat Bone Mass, Structure, and Metabolism by Karesova, Iva, Simko, Julius, Fekete, Sona, Zimcikova, Eva, Malakova, Jana, Zivna, Helena, Pavlikova, Ladislava, Palicka, Vladimir

“…Our study aimed to investigate the effect of zonisamide (ZNS) on bone metabolism in the rat model. Eight-week-old rats were divided into four groups. The…”
Get more information

Vitamin D status of very low birth weight infants at birth and the effects of generally recommended supplementation on their vitamin D levels at discharge by Matejek, Tomas, Navratilova, Martina, Zaloudkova, Lenka, Malakova, Jana, Maly, Jan, Skalova, Sylva, Palicka, Vladimir

“…Purpose: To evaluate vitamin D status in mothers and their very low birth weight infants (VLBW) at birth (umbilical cord blood) and at discharge with currently…”
Get full text