Search Results - "Mal, Tapas K."

NMR Spectroscopy Analysis of Asphaltenes by Ok, Salim, Mal, Tapas K

“…In crude oil production and processing, asphaltene aggregation followed by precipitation is a major problem for the oil industry as it causes deactivation of…”
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Cold-shock induced high-yield protein production in Escherichia coli by Inouye, Masayori, Qing, Guoliang, Ma, Li-Chung, Khorchid, Ahmad, Swapna, G V T, Mal, Tapas K, Takayama, Masanori Mitta, Xia, Bing, Phadtare, Sangita, Ke, Haiping, Acton, Thomas, Montelione, Gaetano T, Ikura, Mitsuhiko

“…Overexpression of proteins in Escherichia coli at low temperature improves their solubility and stability. Here, we apply the unique features of the cspA gene…”
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Structural Basis for Simultaneous Binding of Two Carboxy-terminal Peptides of Plant Glutamate Decarboxylase to Calmodulin by Yap, Kyoko L., Yuan, Tao, Mal, Tapas K., Vogel, Hans J., Ikura, Mitsuhiko

“…Activation of glutamate decarboxylase (GAD) by calcium-bound calmodulin (CaM) is required for normal plant growth through regulation of γ-aminobutyrate and…”
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Ligand-induced Conformational Changes via Flexible Linkers in the Amino-terminal region of the Inositol 1,4,5-Trisphosphate Receptor by Chan, Jenny, Whitten, Andrew E., Jeffries, Cy M., Bosanac, Ivan, Mal, Tapas K., Ito, Jennifer, Porumb, Horea, Michikawa, Takayuki, Mikoshiba, Katsuhiko, Trewhella, Jill, Ikura, Mitsuhiko

“…Cytoplasmic Ca2+ signals are highly regulated by various ion transporters, including the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R), which functions as…”
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Characterization of Dual Substrate Binding Sites in the Homodimeric Structure of Escherichia coli mRNA Interferase MazF by Li, Guang-Yao, Zhang, Yonglong, Chan, Mitchell C.Y., Mal, Tapas K., Hoeflich, Klaus P., Inouye, Masayori, Ikura, Mitsuhiko

“…MazF and MazE constitute a so-called addiction module that is critical for bacterial growth arrest and eventual cell death in response to stress. The MazF…”
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Sample Preparation and Data Analysis for NMR-Based Metabolomics by Mal, Tapas K, Tian, Yuan, Patterson, Andrew D

“…NMR spectroscopy has become one of the preferred analytical techniques for metabolomics studies due to its inherent nondestructive nature, ability to identify…”
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Functional Silencing of TATA-binding Protein (TBP) by a Covalent Linkage of the N-terminal Domain of TBP-associated Factor 1 by Mal, Tapas K., Takahata, Shinya, Ki, Sewon, Zheng, Le, Kokubo, Tetsuro, Ikura, Mitsuhiko

“…General transcription factor TFIID is comprised of TATA-binding protein (TBP) and TBP-associated factors (TAFs), together playing critical roles in regulation…”
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Structural Studies of Inositol 1,4,5-Trisphosphate Receptor: COUPLING LIGAND BINDING TO CHANNEL GATING by Chan, Jenny, Yamazaki, Haruka, Ishiyama, Noboru, Seo, Min-Duk, Mal, Tapas K, Michikawa, Takayuki, Mikoshiba, Katsuhiko, Ikura, Mitsuhiko

“…The three isoforms of the inositol 1,4,5-trisphosphate receptor (IP₃R) exhibit distinct IP₃ sensitivities and cooperativities in calcium (Ca²⁺) channel…”
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Synthesis and crystal structures of two racemic 2-heteroaryl-3-phenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-ones by Hemant P. Yennawar, Tapas K. Mal, Mark A. Olsen, Anthony F. Lagalante, Evelyn M. Louca, Aloura D. Gavalis, Lee J. Silverberg

“…3-Phenyl-2-(thiophen-3-yl)-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-one (C17H12N2OS2, 1) and…”
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Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry by Simonson, Andrew W., Mongia, Agustey S., Aronson, Matthew R., Alumasa, John N., Chan, Dennis C., Lawanprasert, Atip, Howe, Michael D., Bolotsky, Adam, Mal, Tapas K., George, Christy, Ebrahimi, Aida, Baughn, Anthony D., Proctor, Elizabeth A., Keiler, Kenneth C., Medina, Scott H.

“…Precision antimicrobials aim to kill pathogens without damaging commensal bacteria in the host, and thereby cure disease without antibiotic-associated…”
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T3P-Promoted Synthesis of a Series of 2-Aryl-3-phenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-ones and Their Activity against the Kinetoplastid Parasite Trypanosoma brucei by Silverberg, Lee J., Mal, Tapas K., Pacheco, Carlos N., Povelones, Megan L., Malfara, Madeline F., Lagalante, Anthony F., Olsen, Mark A., Yennawar, Hemant P., Sobhi, Hany F., Baney, Kayla R., Bozeman, Robin L., Eroh, Craig S., Fleming, Michael J., Garcia, Tracy L., Gregory, Casey L., Hahn, Julia E., Hatter, Alyssa M., Johns, Lexi L., Klinger, Tianna L., Li, Jennie J., Menig, Andrew J., Muench, Grace C., Ramirez, Melissa E., Reilly, Jordyn, Sacco, Nicole, Sheidy, Alexandra M., Stoner, Marla M., Thompson, Eric N., Yazdani, Soroush F.

“…A series of fourteen 2-aryl-3-phenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-ones was prepared at room temperature by T3P-mediated cyclization of…”
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Crystal structures of the sulfones of 2,3-diphenyl-2,3-dihydro-4H-1,3-benzothiazin-4-one and 2,3-diphenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-one by Hemant P. Yennawar, Tapas K. Mal, Carlos N. Pacheco, Anthony F. Lagalante, Mark A. Olsen, Michael W. Russell, Grace C. Muench, Quentin J. Moyer, Lee J. Silverberg

“…The title sulfones, 2,3-diphenyl-2,3-dihydro-4H-1,3-benzothiazine-1,1,4-trione, C20H15NO3S, and…”
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Structural characterization of NRAS isoform 5 by Markowitz, Joseph, Mal, Tapas K., Yuan, Chunhua, Courtney, Nicholas B., Patel, Mitra, Stiff, Andrew R., Blachly, James, Walker, Christopher, Eisfeld, Ann‐Kathrin, de la Chapelle, Albert, Carson, William E.

“…It was recently discovered that the NRAS isoform 5 (20 amino acids) is expressed in melanoma and results in a more aggressive cell phenotype. This novel…”
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Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand by Ikura, Mitsuhiko, Bosanac, Ivan, Alattia, Jean-René, Mal, Tapas K, Chan, Jenny, Talarico, Susanna, Tong, Frances K, Tong, Kit I, Yoshikawa, Fumio, Furuichi, Teiichi, Iwai, Miwako, Michikawa, Takayuki, Mikoshiba, Katsuhiko

“…In a variety of cells, the Ca2+ signalling process is mediated by the endoplasmic-reticulum-membrane-associated Ca2+ release channel, inositol…”
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Structural Studies of Inositol 1,4,5-Trisphosphate Receptor by Chan, Jenny, Yamazaki, Haruka, Ishiyama, Noboru, Seo, Min-Duk, Mal, Tapas K., Michikawa, Takayuki, Mikoshiba, Katsuhiko, Ikura, Mitsuhiko

“…The three isoforms of the inositol 1,4,5-trisphosphate receptor (IP3R) exhibit distinct IP3 sensitivities and cooperativities in calcium (Ca2+) channel…”
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The ATCUN Domain as a Probe of Intermolecular Interactions:  Application to Calmodulin−Peptide Complexes by Mal, Tapas K, Ikura, Mitsuhiko, Kay, Lewis E

“…The utility of a three-residue Cu2+ binding motif (ATCUN domain) for studying intermolecular interactions is demonstrated. By comparing a set of 1H−15N…”
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Structural and Functional Characterization on the Interaction of Yeast TFIID Subunit TAF1 with TATA-binding Protein by Mal, Tapas K., Masutomi, Yutaka, Zheng, Le, Nakata, Yasuto, Ohta, Hiroshi, Nakatani, Yoshihiro, Kokubo, Tetsuro, Ikura, Mitsuhiko

“…General transcription factor TFIID, consisting of TATA-binding protein (TBP) and TBP-associated factors (TAFs), plays a central role in both positive and…”
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Characterization of the ATP-binding domain of the sarco(endo)plasmic reticulum Ca(2+)-ATPase: probing nucleotide binding by multidimensional NMR by Abu-Abed, Mona, Mal, Tapas K, Kainosho, Masatsune, MacLennan, David H, Ikura, Mitsuhiko

“…The skeletal muscle sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA1a) mediates muscle relaxation by pumping Ca(2+) from the cytosol to the ER/SR lumen. In…”
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Characterization of the ATP-Binding Domain of the Sarco(endo)plasmic Reticulum Ca2+-ATPase:  Probing Nucleotide Binding by Multidimensional NMR by Abu-Abed, Mona, Mal, Tapas K, Kainosho, Masatsune, MacLennan, David H, Ikura, Mitsuhiko

“…The skeletal muscle sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1a) mediates muscle relaxation by pumping Ca2+ from the cytosol to the ER/SR lumen. In…”
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Detecting Protein Kinase Recognition Modes of Calmodulin by Residual Dipolar Couplings in Solution NMR by Mal, Tapas K, Skrynnikov, Nikolai R, Yap, Kyoko L, Kay, Lewis E, Ikura, Mitsuhiko

“…Calmodulin-regulated serine/threonine kinases (CaM kinases) play crucial roles in Ca2+-dependent signaling transduction pathways in eukaryotes. Despite having…”
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