Search Results - "Makynen, A"
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Validation of Questionnaires in Screening for Restorative Treatment Need among 15-, 21-, and 40-year olds
Published in Dental hypotheses (01-01-2022)“…Introduction: This cross-sectional study aims to investigate the association between three age-specific questionnaires in three age groups and restorative…”
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Propiconazole inhibits steroidogenesis and reproduction in the fathead minnow (Pimephales promelas)
Published in Toxicological sciences (01-04-2013)“…Conazoles are designed to inhibit cytochrome P450 (CYP) 14α-demethylase, an enzyme key to fungal cell wall formation. In vertebrates, conazoles may inhibit…”
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3
Effects of a glucocorticoid receptor agonist, dexamethasone, on fathead minnow reproduction, growth, and development
Published in Environmental toxicology and chemistry (01-03-2012)“…Synthetic glucocorticoids are pharmaceutical compounds prescribed in human and veterinary medicine as anti‐inflammatory agents and have the potential to…”
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Evaluation of the Aromatase Inhibitor Fadrozole in a Short-Term Reproduction Assay with the Fathead Minnow (Pimephales promelas)
Published in Toxicological sciences (01-05-2002)“…Cytochrome P450 aromatase (CYP19) is a key enzyme in vertebrate steroidogenesis, catalyzing the conversion of C19 androgens to C18 estrogens such as…”
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5
Identification of metabolites of trenbolone acetate in androgenic runoff from a beef feedlot
Published in Environmental health perspectives (01-04-2006)“…Little is known concerning the potential ecological effects of hormonally active substances associated with discharges from animal feeding operations…”
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Rapid effects of the aromatase inhibitor fadrozole on steroid production and gene expression in the ovary of female fathead minnows (Pimephales promelas)
Published in General and comparative endocrinology (01-10-2017)“…•Estradiol concentrations were altered within hours of exposure to fadrozole.•Estradiol remained depressed over the first 24h of exposure.•Gene expression…”
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Effects of gemfibrozil on lipid metabolism, steroidogenesis, and reproduction in the fathead minnow (Pimephales promelas)
Published in Environmental toxicology and chemistry (01-11-2012)“…Fibrates are a class of pharmaceuticals that indirectly modulate cholesterol biosynthesis through effects on peroxisome proliferator‐activated receptors…”
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Description and evaluation of a short-term reproduction test with the fathead minnow (Pimephales promelas)
Published in Environmental toxicology and chemistry (01-06-2001)“…Due to the time and expense associated with full life‐cycle testing, most current toxicity tests with fish do not explicitly consider reproductive output as an…”
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Effects of a short-term exposure to the fungicide prochloraz on endocrine function and gene expression in female fathead minnows ( Pimephales promelas)
Published in Aquatic toxicology (01-06-2011)“…Prochloraz is a fungicide known to cause endocrine disruption through effects on the hypothalamic–pituitary–gonadal (HPG) axis. To determine the short-term…”
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Ketoconazole in the fathead minnow (Pimephales promelas): Reproductive toxicity and biological compensation
Published in Environmental toxicology and chemistry (01-06-2007)“…Ketoconazole (KTC) is a model pharmaceutical representing imidazole and triazole pesticides, which inhibit fungal growth through blocking a cytochrome P450…”
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Dynamic Nature of Alterations in the Endocrine System of Fathead Minnows Exposed to the Fungicide Prochloraz
Published in Toxicological sciences (01-12-2009)“…The vertebrate hypothalamic-pituitary-gonadal (HPG) axis is controlled through various feedback mechanisms that maintain a dynamic homeostasis in the face of…”
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Effects of the Feedlot Contaminant 17α-Trenbolone on Reproductive Endocrinology of the Fathead Minnow
Published in Environmental science & technology (01-05-2006)“…Trenbolone acetate is a growth promoter widely used for beef production in the U.S. Two biologically active metabolites of the acetate, 17β- and…”
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Direct Effects, Compensation, and Recovery in Female Fathead Minnows Exposed to a Model Aromatase Inhibitor
Published in Environmental health perspectives (01-04-2009)“…Background: Several chemicals in the environment have the potential to inhibit aromatase, an enzyme critical to estrogen synthesis. Objectives: The objective…”
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A time-course analysis of effects of the steroidogenesis inhibitor ketoconazole on components of the hypothalamic-pituitary-gonadal axis of fathead minnows
Published in Aquatic toxicology (15-06-2012)“…► Fathead minnows (Pimephales promelas) were exposed to the fungicide ketoconazole in a time-course study. ► Ketoconazole caused rapid and persistent…”
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REPRODUCTIVE TOXICITY OF VINCLOZOLIN IN THE FATHEAD MINNOW: CONFIRMING AN ANTI-ANDROGENIC MODE OF ACTION
Published in Environmental toxicology and chemistry (01-02-2008)“…The objective of the present study was to characterize responses of the reproductive endocrine system of the fathead minnow (Pimephales promelas) to the…”
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Impacts of an Anti-Androgen and an Androgen/Anti-Androgen Mixture on the Metabolite Profile of Male Fathead Minnow Urine
Published in Environmental science & technology (01-09-2010)“…Male and female fathead minnows (Pimephales promelas, FHM) were exposed via water to 20 or 200 μg/L of cyproterone acetate (CA), a model androgen receptor (AR)…”
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Comparison of fathead minnow ovary explant and H295R cell-based steroidogenesis assays for identifying endocrine-active chemicals
Published in Ecotoxicology and environmental safety (01-09-2007)“…An in vitro steroidogenesis assay using H295R human adenocarcinoma cells has been suggested as a possible alternative to gonad explant assays for use as a Tier…”
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Use of chemical mixtures to differentiate mechanisms of endocrine action in a small fish model
Published in Aquatic toxicology (01-09-2010)“…Various assays with adult fish have been developed to identify potential endocrine-disrupting chemicals (EDCs) which may cause toxicity via alterations in the…”
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Characterization of responses to the antiandrogen flutamide in a short-term reproduction assay with the fathead minnow
Published in Aquatic toxicology (18-11-2004)“…A short-term reproduction assay with the fathead minnow ( Pimephales promelas) has been developed to detect chemicals with the potential to disrupt…”
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Teaching and Evaluation Materials Utilizing Multiple Representations in Mechanics
Published in Physics education (01-05-2013)“…In this paper, we present materials and teaching ideas utilizing multiple representations in the contexts of kinematics and the force concept. These ideas and…”
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