Low-energy electron-induced decomposition of 5-trifluoromethanesulfonyl-uracil: A potential radiosensitizer

5-trifluoromethanesulfonyl-uracil (OTfU), a recently proposed radiosensitizer, is decomposed in the gas-phase by attachment of low-energy electrons. OTfU is a derivative of uracil with a triflate (OTf) group at the C -position, which substantially increases its ability to undergo effective electron-...

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Bibliographic Details
Published in:	The Journal of chemical physics Vol. 149; no. 16; p. 164307
Main Authors:	Ameixa, J, Arthur-Baidoo, E, Meißner, R, Makurat, S, Kozak, W, Butowska, K, Ferreira da Silva, F, Rak, J, Denifl, S
Format:	Journal Article
Language:	English
Published:	United States 28-10-2018
Subjects:	Electrons Molecular Structure Radiation-Sensitizing Agents - chemistry Thermodynamics Uracil - chemistry Uracil - metabolism
Online Access:	Get more information
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Summary:	5-trifluoromethanesulfonyl-uracil (OTfU), a recently proposed radiosensitizer, is decomposed in the gas-phase by attachment of low-energy electrons. OTfU is a derivative of uracil with a triflate (OTf) group at the C -position, which substantially increases its ability to undergo effective electron-induced dissociation. We report a rich assortment of fragments formed upon dissociative electron attachment (DEA), mostly by simple bond cleavages (e.g., dehydrogenation or formation of OTf ). The most favorable DEA channel corresponds to the formation of the triflate anion alongside with the reactive uracil-5-yl radical through the cleavage of the O-C bond, particularly at about 0 eV. Unlike for halouracils, the parent anion was not detected in our experiments. The experimental findings are accounted by a comprehensive theoretical study carried out at the M06-2X/aug-cc-pVTZ level. The latter comprises the thermodynamic thresholds for the formation of the observed anions calculated under the experimental conditions (383.15 K and 3 × 10 atm). The energy-resolved ion yield of the dehydrogenated parent anion, (OTfU-H) , is discussed in terms of vibrational Feshbach resonances arising from the coupling between the dipole bound state and vibrational levels of the transient negative ion. We also report the mass spectrum of the cations obtained through ionization of OTfU by electrons with a kinetic energy of 70 eV. The current study endorses OTfU as a potential radiosensitizer agent with possible applications in radio-chemotherapy.
ISSN:	1089-7690
DOI:	10.1063/1.5050594