Search Results - "Maksimovic, Stefan"
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Do We Have Viable Protective Strategies against Anesthesia-Induced Developmental Neurotoxicity?
Published in International journal of molecular sciences (20-01-2022)“…Since its invention, general anesthesia has been an indispensable component of modern surgery. While traditionally considered safe and beneficial in many…”
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Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons
Published in Neurobiology of disease (01-12-2022)“…Preclinical models demonstrate that nearly all anesthetics cause widespread neuroapoptosis in the developing brains of infant rodents and non-human primates…”
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General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action
Published in International journal of molecular sciences (08-02-2022)“…Over the past three decades, we have been grappling with rapidly accumulating evidence that general anesthetics (GAs) may not be as innocuous for the young…”
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Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3β-OH
Published in Frontiers in pharmacology (23-05-2022)“…We recently reported that a neurosteroid analogue with T-channel-blocking properties (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH), induced hypnosis…”
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Neonatal Isoflurane Does Not Affect Sleep Architecture and Minimally Alters Neuronal Beta Oscillations in Adolescent Rats
Published in Frontiers in behavioral neuroscience (01-11-2021)“…General anesthetics are neurotoxic to the developing rodent and primate brains leading to neurocognitive and socio-affective impairment later in life. In…”
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Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats
Published in British journal of anaesthesia : BJA (01-10-2022)“…General anaesthesia in the neonatal period has detrimental effects on the developing mammalian brain. The impact of underlying inflammation on…”
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Long-term retention of proprioceptive recalibration
Published in Neuropsychologia (01-06-2018)“…Sensorimotor changes are well documented following reaches with altered visual feedback of the hand. Specifically, reaches are adapted and proprioceptive…”
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Cadmium significantly changes major morphometrical points and cardiovascular functional parameters during early development of zebrafish
Published in Environmental toxicology and pharmacology (01-10-2021)“…[Display omitted] •Cd2+ induced delay in hatching rate and yolk sac absorption.•Cd2+ led to smaller cephalic region area, reduced area of the eye and otic…”
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Abstract 2830: Intravital multiphoton microscopy of bone metastatic renal cell carcinoma
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Clear cell renal carcinoma (ccRCC) represents 80% of renal neoplasms, with bone as a major site for distant spread (35-40% of patients). These…”
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Experiencing the Cross-Sensory Error Signal During Movement Leads to Proprioceptive Recalibration
Published in Journal of motor behavior (02-01-2020)“…Reaching to targets in a virtual reality environment with misaligned visual feedback of the hand results in changes in movements (visuomotor adaptation) and…”
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Antiangiogenic Tyrosine Kinase Inhibitors have Differential Efficacy in Clear Cell Renal Cell Carcinoma in Bone
Published in Cancer research communications (01-10-2024)“…Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney neoplasm; bone metastasis (BM) develops in 35% to 40% of metastatic patients and results…”
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