Search Results - "Makofske, R"

Hydrolysis of amyloid precursor protein-derived peptides by cysteine proteinases and extracts of rat brain clathrin-coated vesicles by Marks, N, Berg, M J, Chi, L M, Choi, J, Durrie, R, Swistok, J, Makofske, R C, Danho, W, Sapirstein, V S

“…Amyloid precursor proteins (APPs) and C-terminal fragments were colocalized with cysteine proteinase-like enzymes in purified rat brain clathrin-coated…”
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Facile synthesis of amino acid and peptide esters under mild conditions via cesium salts by Wang, Su-Sun, Gisin, B. F, Winter, D. P, Makofske, R, Kulesha, I. D, Tzougraki, C, Meienhofer, J

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Synthetic domains of cystatins linked to enkephalins are novel inhibitors of brain cathepsins L/B by Marks, N, Berg, M J, Makofske, R C, Danho, W

“…Cystatin domains or homologous sequences were synthesized and tested as inhibitors of papain, and rat brain cathepsins B and L. These domains included: I, an…”
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Peptide and Peptide Mimetic Inhibitors of Antigen Presentation by HLA-DR Class II MHC Molecules. Design, Structure−Activity Relationships, and X-ray Crystal Structures by Bolin, David R, Swain, Amy L, Sarabu, Ramakanth, Berthel, Steven J, Gillespie, Paul, Huby, Nicholas J. S, Makofske, Raymond, Orzechowski, Lucja, Perrotta, Agostino, Toth, Katherine, Cooper, Joel P, Jiang, Nan, Falcioni, Fiorenza, Campbell, Robert, Cox, Donald, Gaizband, Diana, Belunis, Charles J, Vidovic, Damir, Ito, Kouichi, Crowther, Robert, Kammlott, Ursula, Zhang, Xiaolei, Palermo, Robert, Weber, David, Guenot, Jeanmarie, Nagy, Zoltan, Olson, Gary L

“…Molecular features of ligand binding to MHC class II HLA-DR molecules have been elucidated through a combination of peptide structure−activity studies and…”
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Chimeric enkephalin-cystatins: opioid binding and structure-activity relationships of inhibitory domains by Marks, N, Berg, M J, Makofske, R C, Swistok, J, Simon, E J, Ofri, D, Del Compare, K, Danho, W

“…A chimeric inhibitor of cysteine proteinases, YGGFLQVVAGK.amide, was synthesized for use in examining SAR of its cystatin and opioid domains. Analogs were…”
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Preparation of protected peptide hydrazides from the acids and hydrazine by dicyclohexylcarbodiimide-hydroxybenzotriazole coupling by Wang, S S, Kulesha, I D, Winter, D P, Makofske, R, Kutny, R, Meienhofer, J

“…A mild procedure for preparing protected peptide hydrazides directly from the corresponding carboxylic acids and equivalent amounts of hydrazine,…”
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Synthesis and biological activity of novel, potent and long-acting analogs of AC-CCK-7 with high affinity for peripheral (type A) receptors by Danho, W, Makofske, R C, Swistok, J, Michalewsky, J, Gabriel, T, Marks, N, Berg, M J, Baird, L, Geiler, V, Mackie, G

“…Analogs of cholecystokinin (CCK-7) in which the N-terminal Tyr(SO3H) was acetylated, Asp6 replaced with Thr(SO3H) and Phe7 replaced with N-methyl-Phe were…”
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Replacement of the disulfide bond in oxytocin by an amide group. Synthesis and some biological properties of [cyclo-(1-L-aspartic acid, 6-L-.alpha.,.beta.-diaminopropionic acid)]oxytocin by Smith, Clark W, Walter, Roderich, Moore, Stanley, Makofske, Raymond C, Meienhofer, Johannes

“…As part of a continuing investigation of the steric and electronic functions of the disulfide group in neurohypophyseal hormones on their biological activity,…”
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Isolation and identification of thymosin alpha 1 from calf spleen using high performance liquid chromatography by Danho, W, Gabriel, T F, Makofske, R C

“…A peptide isolated from calf spleen has been identified as thymosin alpha 1. The isolation involved defatting of the desiccated glands with acetone, extraction…”
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Preparative oxidative conversion of protected peptide C alpha-hydrazides into the corresponding acids by N-bromosuccinimide by Meienhofer, J, Dzieduszycka, M, Smulkowski, M, Makofske, R C, Danho, W

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Synthesis of a potent enkephalin analog, Tyr-D-Thr-Gly-Phe-delta 3 Pro-NH2, and some of its biological activities by Tzougraki, C, Dairman, W M, Makofske, R C, Aeppli, L, Meienhofer, J

“…The enkephalin analog, H-Tyr-D-Thr-Gly-Phe-delta 3 Pro-NH2 X HCl (VI) ([D-Thr2, delta 3 Pro5]-enkephalinamide), has been synthesized by conventional methods in…”
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Synthesis of human beta-endorphin in solution using benzyl-type side chain protective groups by Tzougraki, C, Makofske, R C, Gabriel, T F, Michalewsky, J, Meienhofer, J, Li, C H

“…A solution synthesis of human beta-endorphin (beta-EP) was carried out by condensation of protected peptide segments bearing N alpha-tert.-butyloxycarbonyl…”
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Carboxylic acids and tetrazoles as isosteric replacements for sulfate in cholecystokinin analogs by Tilley, Jefferson W, Danho, Waleed, Lovey, Kathleen, Wagner, Rolf, Swistok, Joseph, Makofske, Raymond, Michalewsky, Joseph, Triscari, Joseph, Nelson, David, Weatherford, Sally

“…A series of analogues of the satiety-inducing peptide cholecystokinin (CCK-8) was prepared in which the sulfated tyrosine required for activation of peripheral…”
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Analogs of CCK incorporating conformationally constrained replacements for Asp32 by Tilley, Jefferson W, Danho, Waleed, Madison, Vincent, Fry, David, Swistok, Joseph, Makofske, Raymond, Michalewsky, Joseph, Schwartz, Allan, Weatherford, Sally

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Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met28-Gly29 by Tilley, Jefferson W, Danho, Waleed, Shiuey, Shian Jan, Kulesha, Irina, Swistok, Joseph, Makofske, Raymond, Michalewsky, Joseph, Triscari, Joseph, Nelson, David

“…A series of analogs of Ac-CCK-7 [Ac-Tyr(SO3H)-Met28-Gly29-Trp-Met-Asp- Phe-NH2, (1)] were prepared in which the Met28-Gly29 dipeptide was replaced by…”
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Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met super(28)-Gly super(29) by Tilley, J W, Danho, W, Shiuey, Shian-Jan, Kulesha, I, Swistok, J, Makofske, R, Michalewsky, J, Triscari, J, Nelson, D

“…A series of analogs of Ac-CCK-7 (Ac-Tyr(SO sub(3)H)-Met super(28)-Gly super(29)-Trp-Met-Asp-Phe-NH sub(2), (1)) were prepared in which the Met super(28)-Gly…”
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Analogs of CCK incorporating conformationally constrained replacement for Asp32 by TILLEY, J. W, DANHO, W, NELSON, D, MADISON, V, FRY, D, SWISTOK, J, MAKOFSKE, R, MICHALEWSKY, J, SCHWARTZ, A, WEATHERFORD, S, TRISCARI, J

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Solid phase synthesis without repetitive acidolysis. Preparation of leucyl-alanyl-glycyl-valine using 9-fluorenylmethyloxycarbonylamino acids by Meienhofer, J, Waki, M, Heimer, E P, Lambros, T J, Makofske, R C, Chang, C D

“…The utility of repetitive nonhydrolytic base cleavage of alpha-amino protective groups in solid phase peptide synthesis is shown by a preparation of the model…”
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Structure activity of C-terminal modified analogs of Ac-CCK-7 by Tilley, J W, Danho, W, Shiuey, S J, Kulesha, I, Sarabu, R, Swistok, J, Makofske, R, Olson, G L, Chiang, E, Rusiecki, V K

“…Previous work indicates that both the C-terminal phenylalanine amide and the tryptophan moieties of cholecystokinin (CCK) are critical pharmacophores for…”
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Brain cathepsin B but not metalloendopeptidases degrade rAPP751 with production of amyloidogenic fragments. Comparison with synthetic peptides emulating beta- and gamma-secretase sites by Marks, N, Berg, M J, Sapirstein, V S, Durrie, R, Swistok, J, Makofske, R C, Danho, W

“…Lysosomal cathepsin B but not L degraded rAPP751 to yield C-terminal 19-25 kDa fragments containing beta A4, reinforcing the view that acidic proteases…”
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