Search Results - "Mako, M E"

Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood by Horwitz, D L, Starr, J I, Mako, M E, Blackard, W G, Rubenstein, A H

“…Concentrations of insulin, proinsulin, and C-peptide were measured in portal and peripheral venous blood in six nondiabetic, nonobese subjects. Portal vein…”
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Familial Hyperproinsulinemia: Partial Characterization of Circulating Proinsulin-Like Material by Gabbay, Kenneth H., Bergenstal, Richard M., Wolff, Julie, Mako, Mary E., Rubenstein, Arthur H.

“…Familial hyperproinsulinemia is an autosomal dominant defect that is associated with strikingly elevated levels of serum proinsulin-like material. Our studies…”
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Insulin Resistance due to a Defect Distal to the Insulin Receptor: Demonstration in a Patient with Leprechaunism by Kobayashi, Masashi, Olefsky, Jerrold M., Elders, Joycelyn, Mako, Mary E., Given, Bruce D., Schedwie, Heinrich K., Fiser, Robert H., Hintz, Raymond L., Horner, James A., Rubenstein, Arthur H.

“…We have studied a 2-year-old girl with acanthosis nigricans, glucose intolerance, marked hyperinsulinemia, and somatic features characteristic of the…”
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Circulating C-peptide immunoreactivity. Studies in normals and diabetic patients by Block, M B, Mako, M E, Steiner, D F, Rubenstein, A H

“…The discovery of proinsulin and recognition of its intracellular conversion to insulin and C-peptide, which are stored and subsequently secreted together, have…”
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Circulating proinsulin in patients with maturity onset diabetes by Mako, M E, Starr, J I, Rubenstein, A H

“…The contribution of proinsulin to the total serum immunoreactive insulin (IRI) was measured in 59 patients with maturity onset diabetes (23 being treated with…”
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The handling of insulin, proinsulin, and C-peptide by the isolated rat kidney by Rabkin, R, Ross, B D, Mako, M E, Rubenstein, A H

“…The renal handling of proinuslin, insulin, and C-peptide was studied in the isolated perfused rat kidney. At perfusate peptide concentrations below 12 ng./ml…”
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Insulin and the kidney by Rubenstein, A H, Mako, M E, Horwitz, D L

“…Changes in renal function and structure are frequently observed in patients with diabetes mellitus. In the early phases of the disease, alterations in…”
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Insulinoma with low circulating insulin levels: the diagnostic value of proinsulin measurements by Alsever, R N, Roberts, J P, Gerber, J G, Mako, M E, Rubenstein, A H

“…Hypoglycemia coexisting with very low plasma immunoreactive insulin concentrations was found in a 78-year-old woman with an insulinoma. However, the absolute…”
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Peripheral metabolism of insulin, proinsulin, and C-peptide in the pregnant rat by Katz, A I, Lindheimer, M D, Mako, M E, Rubenstein, A H

“…To clarify alterations in carbohydrate metabolism which occur in pregnancy, metabolic clearance rates of insulin, proinsulin, and C-peptide were measured by…”
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C-peptide in conditions other than diabetes mellitus by Horwitz, D L, Rubenstein, A H, Mako, M E, Cruz, A, Blix, P M

“…Measurement of serum and urinary C-peptide has been shown to be of value in several conditions other than diabetes mellitus. It is particularly useful because…”
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Clinical correlations of serum proinsulin-like material in islet cell tumours by Alsever, R N, Stjernholm, M R, Sussman, K E, Mako, M E, Rubenstein, A H

“…To examine the possibility that the concentration of circulating proinsulin-like material (PLM) might be helpful in evaluating the therapeutic response of…”
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C-peptide suppression test for insulinoma by Service, F J, Horwitz, D L, Rubenstein, A H, Kuzuya, H, Mako, M E, Reynolds, C, Molnar, G D

“…During hypoglycemia induced by an infusion of porcine insulin, impaired suppression of endogenous insulin secretion as measured by C-peptide was demonstrated…”
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Diabetes due to secretion of an abnormal insulin by Given, B D, Mako, M E, Tager, H S, Baldwin, D, Markese, J, Rubenstein, A H, Olefsky, J, Kobayashi, M, Kolterman, O, Poucher, R

“…A 51-year-old, nonobese man with diabetes mellitus had marked hyperinsulinemia (70 to 120 muU per milliliter; 502 to 860 pmol per liter) and fasting…”
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Factitious hypoglycemia. Diagnosis by measurement of serum C-peptide immunoreactivity and insulin-binding antibodies by Scarlett, J A, Mako, M E, Rubenstein, A H, Blix, P M, Goldman, J, Horwitz, D L, Tager, H, Jaspan, J B, Stjernholm, M R, Olefsky, J M

“…In seven patients with factitious hypoglycemia due to the surreptitious injection of insulin, we made the diagnosis by measurements of plasma insulin and…”
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Insulin and diabetes by Mako, M E, Rubenstein, A H

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C-Peptide and insulin secretion in Pima Indians and Caucasians: constant fractional hepatic extraction over a wide range of insulin concentrations and in obesity by Savage, P J, Flock, E V, Mako, M E, Blix, P M, Rubenstein, A H, Bennett, P H

“…Peripheral serum insulin and C-peptide concentrations during oral glucose tolerance tests were measured in 10 nondiabetic Pima Indians and 10 nondiabetic…”
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Familial hyperproinsulinemia. An autosomal dominant defect by Gabbay, K H, DeLuca, K, Fisher, Jr, J N, Mako, M E, Rubenstein, A H

“…We describe a genetic defect in a kindred in whom proinsulin or a proinsulin-like material constitutes the major fraction of circulating insulin…”
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Insulin and proinsulin metabolism in an unusual case of insulinoma by Kreines, K, Starr, J I, Mako, M E

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Abnormalities in circulating beta cell peptides in chronic renal failure: comparison of C-peptide, proinsulin and insulin by Jaspan, J B, Mako, M E, Kuzuya, H, Blix, P M, Horwitz, D L, Rubenstein, A H

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Sequential changes in beta-cell function in insulin-treated diabetic patients assessed by C-peptide immunoreactivity by Block, M B, Rosenfield, R L, Mako, M E, Steiner, D F, Rubenstein, A H

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