Successful early treatment in a case of Cogan's syndrome

We report a 53-year-old male with Cogan's syndrome. He was admitted to our hospital because of a fever of 2-weeks duration, blurred vision for 10 days, hypoacusis, and numbness of the left hand for 3 days. In addition to uveitis, hypoacusis, and aseptic meningitis, multiple mononeuropathy was d...

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Bibliographic Details
Published in:	Nihon Rinshō Menʾeki Gakkai kaishi Vol. 35; no. 1; p. 92
Main Authors:	Tsuno, Hirotaka, Takahashi, Yuko, Yoshida, Yuji, Arai, Naotoshi, Nakamura, Yousuke, Yashiro, Seiko, Makizumi, Masami, Yamashita, Hiroyuki, Kaneko, Hiroshi, Kano, Toshikazu, Mimori, Akio
Format:	Journal Article
Language:	Japanese
Published:	Japan 2012
Subjects:	Cogan Syndrome - diagnostic imaging Cogan Syndrome - physiopathology Cogan Syndrome - therapy Early Medical Intervention Humans Male Middle Aged Multimodal Imaging Positron-Emission Tomography Tomography, X-Ray Computed
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Summary:	We report a 53-year-old male with Cogan's syndrome. He was admitted to our hospital because of a fever of 2-weeks duration, blurred vision for 10 days, hypoacusis, and numbness of the left hand for 3 days. In addition to uveitis, hypoacusis, and aseptic meningitis, multiple mononeuropathy was diagnosed based on a nerve conduction study. Furthermore, positron emission tomography/computed tomography (PET/CT) revealed diffuse aortitis. Accordingly, the patient was diagnosed with Cogan's syndrome. After starting steroid-pulse therapy followed by 1 mg oral prednisolone/kg/day, the uveitis and hypoacusis improved immediately, while the peripheral neuropathy persisted until effectively treated with intravenous gamma globulin therapy. Prompt steroid therapy for Cogan's syndrome based on a diagnosis made using PET/CT prevented progression of the hypoacusis.
ISSN:	1349-7413
DOI:	10.2177/jsci.35.92