Search Results - "Makino, Takamitsu"

Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts by Nakashima, Taiji, Jinnin, Masatoshi, Yamane, Keitaro, Honda, Noritoshi, Kajihara, Ikko, Makino, Takamitsu, Masuguchi, Shinichi, Fukushima, Satoshi, Okamoto, Yoshinobu, Hasegawa, Minoru, Fujimoto, Manabu, Ihn, Hironobu

“…Among IL-17 families, IL-17A and IL-17F share amino acid sequence similarity and bind to IL-17R type A. IL-17 signaling is implicated in the pathogenesis of…”
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The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma by Makino, Katsunari, Jinnin, Masatoshi, Hirano, Ayaka, Yamane, Keitaro, Eto, Mitsuhiko, Kusano, Takamitsu, Honda, Noritoshi, Kajihara, Ikko, Makino, Takamitsu, Sakai, Keisuke, Masuguchi, Shinichi, Fukushima, Satoshi, Ihn, Hironobu

“…Systemic and localized scleroderma (SSc and LSc) is characterized by excessive deposition of collagen and tissue fibrosis in the skin. Although they have…”
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Elevated Alpha 1(I) to Alpha 2(I) Collagen Ratio in Dermal Fibroblasts Possibly Contributes to Fibrosis in Systemic Sclerosis by Sawamura, Soichiro, Makino, Katsunari, Ide, Maho, Shimada, Shuichi, Kajihara, Ikko, Makino, Takamitsu, Jinnin, Masatoshi, Fukushima, Satoshi

“…Systemic sclerosis (SSc) is characterized by excessive collagen deposition in the skin and internal organs. Activated fibroblasts are the key effector cells…”
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Genetic and epigenetic abnormalities in systemic sclerosis by Makino, Takamitsu, Jinnin, Masatoshi

“…Systemic sclerosis (SSc) is a complicated autoimmune and connective tissue disease, of which the pathogenesis and treatment have not been fully elucidated. SSc…”
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Effect of topical immunotherapy with squaric acid dibutylester for alopecia areata in Japanese patients by Sakai, Keisuke, Fukushima, Satoshi, Mizuhashi, Satoru, Jinnin, Masatoshi, Makino, Takamitsu, Inoue, Yuji, Ihn, Hironobu

“…The Japanese guidelines for the treatment of alopecia areata list topical immunotherapies as a drug therapy for this condition. However, there is insufficient…”
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miR-150 Down-Regulation Contributes to the Constitutive Type I Collagen Overexpression in Scleroderma Dermal Fibroblasts via the Induction of Integrin β3 by Honda, Noritoshi, Jinnin, Masatoshi, Kira-Etoh, Tomomi, Makino, Katsunari, Kajihara, Ikko, Makino, Takamitsu, Fukushima, Satoshi, Inoue, Yuji, Okamoto, Yoshinobu, Hasegawa, Minoru, Fujimoto, Manabu, Ihn, Hironobu

“…Overexpression of integrins in dermal fibroblasts is thought to play a key role in the pathogenesis of systemic sclerosis (SSc), but the mechanism is unknown…”
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Skin microbiome in acral melanoma: Corynebacterium is associated with advanced melanoma by Mizuhashi, Satoru, Kajihara, Ikko, Sawamura, Soichiro, Kanemaru, Hisashi, Makino, Katsunari, Aoi, Jun, Makino, Takamitsu, Masuguchi, Shinichi, Fukushima, Satoshi, Ihn, Hironobu

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yRNA3 up-regulation in cultured dermal fibroblasts and yRNA4 down-regulation in the sera of scleroderma patients by Tani, Sayaka, Kaminaka, Chikako, Nishiyama, Kosuke, Yariyama, Azusa, Nakatani, Yumi, Inaba, Yutaka, Kunimoto, Kayo, Yamamoto, Yuki, Makino, Katsunari, Makino, Takamitsu, Jinnin, Masatoshi

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Regulatory mechanisms of collagen expression by interleukin-22 signaling in scleroderma fibroblasts by Sawamura, Soichiro, Jinnin, Masatoshi, Inoue, Kuniko, Yamane, Keitaro, Honda, Noritoshi, Kajihara, Ikko, Makino, Takamitsu, Masuguchi, Shinichi, Fukushima, Satoshi, Ihn, Hironobu

“…•The protein level of type I collagen was increased by IL-22 stimulation without changing mRNA levels in cultured normal dermal fibroblast.•IL-22-mediated…”
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CXCL17-mediated downregulation of type I collagen via MMP1 and miR-29 in skin fibroblasts possibly contributes to the fibrosis in systemic sclerosis by Shimada, Shuichi, Makino, Katsunari, Jinnin, Masatoshi, Sawamura, Soichiro, Kawano, Yuya, Ide, Maho, Kajihara, Ikko, Makino, Takamitsu, Fukushima, Satoshi, Ihn, Hironobu

“…•CXCL17 reduced type I collagen expression via MMP1 and miR-29 in skin fibroblasts.•CXCL17 levels in SSc skin were lower than those in healthy controls.•CXCL17…”
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Elevated circulating cell‐free DNA levels in autoimmune bullous diseases by Kakitsuka, Yuki, Sawamura, Soichiro, Kajihara, Ikko, Kanemaru, Hisashi, Honda, Noritoshi, Makino, Katsunari, Aoi, Jun, Makino, Takamitsu, Fukushima, Satoshi, Ihn, Hironobu

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Overexpression of Janus kinase 2 protein in extramammary Paget’s disease by Otsuka-Maeda, Saki, Mijiddorj, Myangat Tselmeg, Kajihara, Ikko, Sakamoto, Ryoko, Yamada-Kanazawa, Saori, Kanemaru, Hisashi, Nishimura, Yuki, Sawamura, Soichiro, Makino, Katsunari, Aoi, Jun, Makino, Takamitsu, Masuguchi, Shinichi, Fukushima, Satoshi, Ihn, Hironobu

“…Abstract Extramammary Paget’s disease is a rare malignant tumor of the skin that occurs primarily in the genitocrural region. Although the prognosis of…”
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Liquid biopsy-based analysis by ddPCR and CAPP-Seq in melanoma patients by Kaneko, Akira, Kanemaru, Hisashi, Kajihara, Ikko, Mijiddorj, Tselmeg, Miyauchi, Hitomi, Kuriyama, Haruka, Kimura, Toshihiro, Sawamura, Soichiro, Makino, Katsunari, Miyashita, Azusa, Aoi, Jun, Makino, Takamitsu, Masuguchi, Shinichi, Fukushima, Satoshi, Ihn, Hironobu

“…•Cell-free DNA (cfDNA) from melanoma patients was analyzed by liquid biopsy.•CAncer Personalized Profiling by deep Sequencing (CAPP-Seq) was…”
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Case of generalized morphea complicated with systemic sclerosis by Sawamura, Soichiro, Makino, Katsunari, Nakashima, Hitomi, Makino, Takamitsu, Fukushima, Satoshi

“…Dear Editor, Localized scleroderma (LSc; morphea) is a rare fibrosing disease of the skin and underlying tissues, which is different from systemic sclerosis…”
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Overexpression of cyclin‐dependent kinase 4 protein in extramammary Paget's disease by Urata, Kazumi, Kajihara, Ikko, Myangat, Tselmeg Mijiddorj, Tasaki, Yukino, Otsuka‐Maeda, Saki, Sawamura, Soichiro, Kanazawa‐Yamada, Saori, Sakamoto, Ryoko, Makino, Katsunari, Aoi, Jun, Igata, Toshikatsu, Makino, Takamitsu, Masuguchi, Shinichi, Fukushima, Satoshi, Jinnin, Masatoshi, Ihn, Hironobu

“…Cyclin‐dependent kinase 4 and 6 (CDK4/6) plays an important role in cell cycle progression, and the CDK4/6–cyclin D1 complex controls the cell cycle transition…”
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Circulating tumor necrosis factor‐α DNA are elevated in psoriasis by Sakamoto, Ryoko, Sawamura, Soichiro, Kajihara, Ikko, Miyauchi, Hitomi, Urata, Kazumi, Otsuka‐Maeda, Saki, Kanemaru, Hisashi, Kanazawa‐Yamada, Saori, Honda, Noritoshi, Makino, Katsunari, Miyashita, Azusa, Aoi, Jun, Makino, Takamitsu, Fukushima, Satoshi, Ihn, Hironobu

“…In psoriasis, tumor necrosis factor (TNF)‐α is a key pro‐inflammatory cytokine that activates keratinocytes to produce other inflammatory mediators. In…”
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EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin by Kudo, Hideo, Wang, Zhongzhi, Jinnin, Masatoshi, Nakayama, Wakana, Inoue, Kuniko, Honda, Noritoshi, Nakashima, Taiji, Kajihara, Ikko, Makino, Katsunari, Makino, Takamitsu, Fukushima, Satoshi, Ihn, Hironobu

“…IL-12 family cytokines are implicated in the pathogenesis of various autoimmune diseases, but their role in the regulation of extracellular matrix expression…”
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Serum levels of desmoglein‐1 DNA copies in cell‐free DNA of patients with pemphigus by Kakitsuka, Yuki, Sawamura, Soichiro, Kajihara, Ikko, Kanemaru, Hisashi, Honda, Noritoshi, Makino, Katsunari, Aoi, Jun, Makino, Takamitsu, Fukushima, Satoshi, Ihn, Hironobu

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Discoidin Domain Receptor 2–microRNA 196a–Mediated Negative Feedback against Excess Type I Collagen Expression Is Impaired in Scleroderma Dermal Fibroblasts by Makino, Katsunari, Jinnin, Masatoshi, Aoi, Jun, Hirano, Ayaka, Kajihara, Ikko, Makino, Takamitsu, Sakai, Keisuke, Fukushima, Satoshi, Inoue, Yuji, Ihn, Hironobu

“…Systemic sclerosis (SSc) is characterized by excess collagen deposition in the skin, due to intrinsic transforming growth factor-β (TGF-β) activation. We tried…”
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Single administration of avelumab induced a complete response in thyroid transcription factor 1‐positive combined Merkel cell carcinoma by Kanemaru, Hisashi, Fukushima, Satoshi, Mizukami, Yukari, Sawamura, Soichiro, Nakamura, Kayo, Honda, Noritoshi, Makino, Katsunari, Kajihara, Ikko, Aoi, Jun, Makino, Takamitsu, Kawasaki, Takeshi, Kudou, Erina, Jhono, Masayoshi, Ito, Takaaki, Arima, Nobuyuki, Ihn, Hironobu

“…Merkel cell carcinoma (MCC) is an aggressive neoplasm and patients with metastasis have poor survival outcomes. Recently, avelumab, an anti‐programmed death…”
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