Search Results - "Makinen, Shawn"

Intranasal immunization with a proteosome-adjuvanted SARS-CoV-2 spike protein-based vaccine is immunogenic and efficacious in mice and hamsters by Stark, Felicity C., Akache, Bassel, Deschatelets, Lise, Tran, Anh, Stuible, Matthew, Durocher, Yves, McCluskie, Michael J., Agbayani, Gerard, Dudani, Renu, Harrison, Blair A., Renner, Tyler M., Makinen, Shawn R., Bavananthasivam, Jegarubee, Duque, Diana, Gagne, Martin, Zimmermann, Joseph, Zarley, C. David, Cochrane, Terrence R., Handfield, Martin

“…With the persistence of the SARS-CoV-2 pandemic and the emergence of novel variants, the development of novel vaccine formulations with enhanced immunogenicity…”
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CpG-mediated augmentation of CD8+ T-cell responses in mice is attenuated by a water-in-oil emulsion (Montanide ISA-51) but enhanced by an oil-in-water emulsion (IDRI SE) by Makinen, Shawn R, Zhu, Qin, Davis, Heather L, Weeratna, Risini D

“…Adjuvants are a key component in enhancing immunogenicity of vaccines and play a vital role in facilitating the induction of the correct type of immunity…”
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Paclitaxel reduces regulatory T cell numbers and inhibitory function and enhances the anti-tumor effects of the TLR9 agonist PF-3512676 in the mouse by Vicari, Alain P, Luu, Rachel, Zhang, Ningli, Patel, Shobhna, Makinen, Shawn R, Hanson, Douglas C, Weeratna, Risini D, Krieg, Arthur M

“…The anti-tumor properties of Toll-like receptor (TLR) 9 agonist CpG oligodeoxynucleotides (ODN) are enhanced by combinations with several cytotoxic…”
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Sulfated Lactosyl Archaeol Archaeosome-Adjuvanted Vaccine Formulations Targeting Rabbit Hemorrhagic Disease Virus Are Immunogenic and Efficacious by Akache, Bassel, Read, Andrew J, Dudani, Renu, Harrison, Blair A, Williams, Dean, Deschatelets, Lise, Jia, Yimei, Chandan, Vandana, Stark, Felicity C, Agbayani, Gerard, Makinen, Shawn R, Hemraz, Usha D, Lam, Edmond, Régnier, Sophie, Zou, Wei, Kirkland, Peter D, McCluskie, Michael J

“…Vaccines play an important role in maintaining human and animal health worldwide. There is continued demand for effective and safe adjuvants capable of…”
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TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848) by Weeratna, Risini D., Makinen, Shawn R., McCluskie, Michael J., Davis, Heather L.

“…TLR ligands that mimic pathogen associated molecular patterns and activate immune cells via Toll-like receptors (TLRs) are being developed for use in humans as…”
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In vivo screen of genetically conserved Streptococcus pneumoniae proteins for protective immunogenicity by Anderson, Richard J, Guru, Siradanahalli, Weeratna, Risini, Makinen, Shawn, Falconer, Derek J, Sheppard, Neil C, Lang, Susanne, Chang, Bingsheng, Goenaga, Anne-Laure, Green, Bruce A, Merson, James R, Gracheck, Stephen J, Eyles, Jim E

“…Highlights • Immunizing efficacy of 52 pneumococcal proteins evaluated in a mouse challenge model. • Proteins were selected based on genetic conservation and…”
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CpG ODN and ISCOMATRIX Adjuvant: A Synergistic Adjuvant Combination Inducing Strong T-Cell IFN-γ Responses by Drane, Debbie, Makinen, Shawn, Evans, Dana M., Weeratna, Risini D., McCluskie, Michael J., Davis, Heather L.

“…For the induction of robust humoral and cellular immune responses, a strong rationale exists to use vaccine-adjuvant combinations possessing both immune…”
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Nonreplicating Vaccines Can Protect African Green Monkeys From the Memphis 37 Strain of Respiratory Syncytial Virus by Eyles, Jim E., Johnson, J. Erik, Megati, Shakuntala, Roopchand, Vidia, Cockle, Paul J., Weeratna, Risini, Makinen, Shawn, Brown, Tom P., Lang, Susanne, Witko, Susan E., Kotash, Cheryl S., Li, Julia, West, Kate, Maldonado, Oscar, Falconer, Derek J., Lees, Clare, Smith, George J., White, Phil, Wright, Paul, Loudon, Peter T., Merson, James R., Jansen, Kathrin U., Sidhu, Maninder K.

“…Background. We evaluated the immunological responses of African green monkeys immunized with multiple F and G protein—based vaccines and assessed protection…”
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