A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery

(N Engl J Med. 2019;380:1012–1021)It is unclear whether or not antibiotic prophylaxis prior to surgery to complete spontaneous abortion (removal of retained products of conception) can reduce postoperative pelvic infection. Evidence is lacking and international guidelines regarding this issue are al...

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Published in:Obstetric anesthesia digest Vol. 39; no. 3; pp. 152 - 153
Main Authors: Lissauer, D, Wilson, A, Hewitt, C.A, Middleton, L, Bishop, J.R.B, Daniels, J, Merriel, A, Weeks, A, Mhango, C, Mataya, R, Taulo, F, Ngalawesa, T, Chirwa, A, Mphasa, C, Tambala, T, Chiudzu, G, Mwalwanda, C, Mboma, A, Qureshi, R, Ahmed, I, Ismail, H, Oladapo, O.T, Mbaruku, G, Chibwana, J, Watts, G, Simon, B, Ditai, J, Otim Tom, C, Acam, J, Ekunait, J, Unzia, H, Iyaku, M, Makiika, J.J, Zamora, J, Roberts, T, Goranitis, I, Bar-Zeev, S, Desmond, N, Arulkumaran, S, Bhutta, Z.A, Gulmezoglu, A.M, Coomarasamy, A
Format: Journal Article
Language:English
Published: Copyright Wolters Kluwer Health, Inc. All rights reserved 01-09-2019
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Summary:(N Engl J Med. 2019;380:1012–1021)It is unclear whether or not antibiotic prophylaxis prior to surgery to complete spontaneous abortion (removal of retained products of conception) can reduce postoperative pelvic infection. Evidence is lacking and international guidelines regarding this issue are also inconsistent. This issue is particularly concerning for women in low-income and middle-income countries, where rates of surgery for incomplete spontaneous abortion are high, and where pelvic infection can lead to serious illness and death. In order to help clarify this issue, the authors of the present study assessed the use of antibiotic prophylaxis (doxycycline and metronidazole, both inexpensive, heat-stable, and widely available) in women undergoing surgery to complete spontaneous abortion in low-resource settings.
ISSN:0275-665X
1536-5395
DOI:10.1097/01.aoa.0000575220.38445.03