Search Results - "Makhlouf, Amal"

Improved vaginal retention and enhanced antifungal activity of miconazole microsponges gel: Formulation development and in vivo therapeutic efficacy in rats by Salah, Salwa, Awad, Ghada E.A., Makhlouf, Amal I.A.

“…Traditional azole antifungal formulations suffer from poor retention in the vaginal cavity, irritation and burning of the vaginal area. In the present work, we…”
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Scalable flibanserin nanocrystal-based novel sublingual platform for female hypoactive sexual desire disorder: engineering, optimization adopting the desirability function approach and in vivo pharmacokinetic study by Naguib, Marianne J., Makhlouf, Amal I. A.

“…Flibanserin (FLB) was approved by FDA for the treatment of pre-menopausal female hypoactive sexual desire disorder (HSDD). FLB suffers from low oral…”
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Implementing polymeric pseudorotaxanes for boosting corneal permeability and antiaspergillus activity of tolnaftate: formulation development, statistical optimization, ex vivo permeation and in vivo assessment by Aziz, Diana, Mohamed, Sally, Tayel, Saadia, Makhlouf, Amal

“…Fungal keratitis (FK) is a devastating ocular disease that can cause corneal opacity and blindness if not treated effectively. Tolnaftate (TOL) is a selective…”
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Enhanced Oral Absorption of Amisulpride Via a Nanostructured Lipid Carrier-Based Capsules: Development, Optimization Applying the Desirability Function Approach and In Vivo Pharmacokinetic Study by El Assasy, Abd El-Halim I., Younes, Niha F., Makhlouf, Amal I. A.

“…Amisulpride (AMS), a second generation antipsychotic, suffers from low oral bioavailability (48%). This might be due to its pH-dependent solubility or being a…”
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Nano Milk Protein-Mucilage Complexes: Characterization and Anticancer Effect by El-Maksoud, Ahmed Ali Abd, Makhlouf, Amal I A, Altemimi, Ammar B, El-Ghany, Ismail H Abd, Nassrallah, Amr, Cacciola, Francesco, Abedelmaksoud, Tarek Gamal

“…The anticancer activity of natural compounds has recently attracted multidisciplinary research. In this study, the complexation of milk proteins (MP) with…”
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Relieving postherpetic neuralgia pain via gabapentin-loaded bigels as an auspicious topical drug delivery system by Abd-Elsalam, Wessam H., Al-Mahallawi, Abdulaziz Mohsen, Makhlouf, Amal

“…Background Over the past decades, a substantial portion of the population worldwide has been infected with varicella zoster and most cases developed shingles…”
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Microenvironmental pH-modified Amisulpride-Labrasol matrix tablets: development, optimization and in vivo pharmacokinetic study by Younes, Nihal Farid, El Assasy, Abd El-Halim I., Makhlouf, Amal I.A.

“…Amisulpride (AMS) is atypical antipsychotic with a weak basic nature (pKa 9.37), which results in low solubility in the high pH of the intestine. It is also…”
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Development and preclinical evaluation of cixutumumab drug conjugates in a model of insulin growth factor receptor I (IGF-1R) positive cancer by Solomon, Viswas Raja, Alizadeh, Elahe, Bernhard, Wendy, Makhlouf, Amal, Hartimath, Siddesh V., Hill, Wayne, El-Sayed, Ayman, Barreto, Kris, Geyer, Clarence Ronald, Fonge, Humphrey

“…Overexpression of insulin growth factor receptor type 1 (IGF-1R) is observed in many cancers. Antibody drug conjugates (ADCs) with PEGylated maytansine (PEG 6…”
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Enhanced Ocular Anti-Aspergillus Activity of Tolnaftate Employing Novel Cosolvent-Modified Spanlastics: Formulation, Statistical Optimization, Kill Kinetics, Ex Vivo Trans-Corneal Permeation, In Vivo Histopathological and Susceptibility Study by Aziz, Diana, Mohamed, Sally A, Tayel, Saadia, Makhlouf, Amal

“…Tolnaftate (TOL) is a thiocarbamate fungicidal drug used topically in the form of creams and ointments. No ocular formulations of TOL are available for fungal…”
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Nose to brain delivery of mirtazapine via lipid nanocapsules: Preparation, statistical optimization, radiolabeling, in vivo biodistribution and pharmacokinetic study by Ibrahim, Mennatullah M., Basalious, Emad B., El-Nabarawi, Mohamed A., Makhlouf, Amal IA, Sayyed, Marwa Eid, Ibrahim, Ismail Taha

“…Mirtazapine (MZPc) is an antidepressant drug which is approved by the FDA. It has low bioavailability, which is only 50%, in spite of its rapid absorption when…”
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Design, Optimization, and Evaluation of a Novel Metronidazole-Loaded Gastro-Retentive pH-Sensitive Hydrogel by El-Mahrouk, Galal M., Aboul-Einien, Mona H., Makhlouf, Amal I.

“…ABSTRACT Floating pH-sensitive chitosan hydrogels containing metronidazole were developed for the eradication of Helicobacter pylori from the stomach…”
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Correction to: Enhanced Oral Absorption of Amisulpride Via a Nanostructured Lipid Carrier-Based Capsules: Development, Optimization Applying the Desirability Function Approach and In Vivo Pharmacokinetic Study by El Assasy, Abd El-Halim I., Younes, Nihal Farid, Makhlouf, Amal I. A.

“…The second author’s name was incorrectly published as “Niha F. Younes”. The correct name is “Nihal Farid Younes” as shown above in the list of authors…”
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Hair regrowth boosting via minoxidil cubosomes: Formulation development, in vivo hair regrowth evaluation, histopathological examination and confocal laser microscopy imaging by Makhlouf, Amal, Elnawawy, Tayseer

“…[Display omitted] Minoxidil has been used as an effective and cost-efficient topical treatment for androgenic alopecia. However, due to its poor water…”
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Flexosomes as a promising nanoplatform for enhancing tolnaftate ocular delivery: Formulation, in vitro characterization, statistical optimization, ex vivo and microbial in vivo studies by Aziz, Diana, Mohamed, Sally, Tayel, Saadia, Makhlouf, Amal

“…[Display omitted] The eye is a complex organ with a unique physiology and anatomy. Using novel nanosystems is expected to enhance ocular drug permeation and…”
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Adoption of polymeric micelles to enhance the oral bioavailability of dexibuprofen: formulation, in-vitro evaluation and in-vivo pharmacokinetic study in healthy human volunteers by Abdelbary, Ghada, Makhlouf, Amal

“…Abstract This work aimed to incorporate Dexibuprofen (DXI), the pharmacologically active and more potent form of ibuprofen, into polymeric micelles based…”
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sup 89^Zr-labeled domain II specific anti-EGFR ScFv-Fc antibody fragment for imaging and monitoring of response to anti-EGFR treatment by PET by Alizadeh, Elahe, Solomon, Viswas Raja, Zuluaga, Carolina, Bernhard, Wendy, Makhlouf, Amal, Barreto, Kris, Geyer, Clarence, Fonge, Humphrey

“…Objectives: Epidermal growth factor receptor I (EGFR) is overexpressed in multiple cancers where it confers enhanced proliferation and resistance to targeted…”
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89Zr-labeled domain II specific anti-EGFR ScFv-Fc antibody fragment for imaging and monitoring of response to anti-EGFR treatment by PET by Alizadeh, Elahe, Solomon, Viswas Raja, Zuluaga, Carolina, Bernhard, Wendy, Makhlouf, Amal, Barreto, Kris, Geyer, Clarence, Fonge, Humphrey

“…Objectives: Epidermal growth factor receptor I (EGFR) is overexpressed in multiple cancers where it confers enhanced proliferation and resistance to targeted…”
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111 In-Labeled Glycoprotein Nonmetastatic b (GPNMB) Targeted Gemini Surfactant-Based Nanoparticles against Melanoma: In Vitro Characterization and in Vivo Evaluation in Melanoma Mouse Xenograft Model by Makhlouf, Amal, Hajdu, Istvan, Hartimath, Siddesh V, Alizadeh, Elahe, Wharton, Kayla, Wasan, Kishor M, Badea, Ildiko, Fonge, Humphrey

“…Melanoma is a devastating form of skin cancer with high tendency to metastasis. This work addresses the development of new targeted nanoparticles that can be…”
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111In-Labeled Glycoprotein Nonmetastatic b (GPNMB) Targeted Gemini Surfactant-Based Nanoparticles against Melanoma: In Vitro Characterization and in Vivo Evaluation in Melanoma Mouse Xenograft Model by Makhlouf, Amal, Hajdu, Istvan, Hartimath, Siddesh V, Alizadeh, Elahe, Wharton, Kayla, Wasan, Kishor M, Badea, Ildiko, Fonge, Humphrey

“…Melanoma is a devastating form of skin cancer with high tendency to metastasis. This work addresses the development of new targeted nanoparticles that can be…”
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Therapeutic potential of nimotuzumab PEGylated-maytansine antibody drug conjugates against EGFR positive xenograft by Hartimath, Siddesh V, El-Sayed, Ayman, Makhlouf, Amal, Bernhard, Wendy, Gonzalez, Carolina, Hill, Wayne, Parada, Angel Casaco, Barreto, Kris, Geyer, Clarence Ronald, Fonge, Humphrey

“…Nimotuzumab is a humanized anti-epidermal growth factor receptor I (EGFR) monoclonal antibody. We have developed antibody drug conjugates (ADCs) with…”
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