Search Results - "Makhafola, Tshepiso J."

Investigating the Phytochemical Composition, Antioxidant, and Anti-Inflammatory Potentials of Cassinopsis ilicifolia (Hochst.) Kuntze Extract against Some Oxidative Stress and Inflammation Molecular Markers by Mfotie Njoya, Emmanuel, McGaw, Lyndy J, Makhafola, Tshepiso J

“…Oxidative stress is a key factor that activates several transcription factors and mediators involved in the inflammatory pathways responsible for the…”
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HIV-Associated Cancer Biomarkers: A Requirement for Early Diagnosis by Dlamini, Zodwa, Mbele, Mzwandile, Makhafola, Tshepiso J., Hull, Rodney, Marima, Rahaba

“…Globally, HIV/AIDS and cancer are increasingly public health problems and continue to exist as comorbidities. The sub-Saharan African region has the largest…”
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The ameliorative effect of zinc acetate with caffeic acid in the animal model of type 2 diabetes by Matowane, Godfrey R., Mashele, Samson S., Makhafola, Tshepiso J., Chukwuma, Chika I.

“…Recently the complexation-mediated antioxidative and glycaemic control synergism between zinc(II) and caffeic acid was demonstrated in vitro. The present study…”
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Zinc(II) – Syringic acid complexation synergistically exerts antioxidant action and modulates glucose uptake and utilization in L-6 myotubes and rat muscle tissue by Ramorobi, Limpho M., Matowane, Godfrey R., Mashele, Samson S., Swain, Shasank S., Makhafola, Tshepiso J., Mfengwana, Polo-Ma-Abiele H., Chukwuma, Chika I.

“…Zinc and syringic acid have metabolic and antioxidant medicinal potentials. A novel zinc(II)–syringic acid complex with improved anti-hyperglycaemic and…”
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In vitro antiproliferative, anti-inflammatory effects and molecular docking studies of natural compounds isolated from Sarcocephalus pobeguinii (Hua ex Pobég) by Mfotie Njoya, Emmanuel, Ndemangou, Brigitte, Akinyelu, Jude, Munvera, Aristide M, Chukwuma, Chika I, Mkounga, Pierre, Mashele, Samson S, Makhafola, Tshepiso J, McGaw, Lyndy J

“…(Hua ex Pobég) is used in folk medicine to treat oxidative-stress related diseases, thereby warranting the investigation of its anticancer and…”
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Phytoconstituents of Androstachys johnsonii Prain Prevent Reactive Oxygen Species Production and Regulate the Expression of Inflammatory Mediators in LPS-Stimulated RAW 264.7 Macrophages by Mfotie Njoya, Emmanuel, Tabakam, Gaetan T, Chukwuma, Chika I, Mashele, Samson S, Makhafola, Tshepiso J

“…According to a survey, the medicinal use of Prain is kept secret by traditional healers. Considering that inflammation and oxidative stress are major risk…”
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Epicatechin Isolated from Litchi chinensis Sonn. (Litchi) Fruit Peel Ethyl Acetate Extract Modulated Glucose Uptake in Chang Cells and Suppressed ROS Production in RAW 264.7 Macrophages by Izu, Gloria O, Mapasa, Nomonde P, Nambooze, Jennifer, Chukwuma, Maria S, Njoya, Emmanuel Mfotie, Tabakam, Gaetan T, Bonnet, Susanna L, Makhafola, Tshepiso J, Mashele, Samson S, Chukwuma, Chika I

“…Bioactive flavonoid epicatechin has been reported in the peel of litchi fruit but isolated from its hydroalcoholic extracts. This study isolated epicatechin…”
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Unravelling the Influence of Chlorogenic Acid on the Antioxidant Phytochemistry of Avocado ( Persea americana Mill.) Fruit Peel by Izu, Gloria O, Mfotie Njoya, Emmanuel, Tabakam, Gaetan T, Nambooze, Jennifer, Otukile, Kgalaletso P, Tsoeu, Seiso E, Fasiku, Victoria O, Adegoke, Ayodeji M, Erukainure, Ochuko L, Mashele, Samson S, Makhafola, Tshepiso J, Sekhoacha, Mamello P, Chukwuma, Chika I

“…Oxidative stress is pivotal in the pathology of many diseases. This study investigated the antioxidant phytochemistry of avocado ( Mill.) peel. Different…”
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Natural Compounds Isolated from African Mistletoes (Loranthaceae) Exert Anti-Inflammatory and Acetylcholinesterase Inhibitory Potentials: In Vitro and In Silico Studies by Mfotie Njoya, Emmanuel, Maza, Hermine L. D., Swain, Shasank S., Chukwuma, Chika. I., Mkounga, Pierre, Nguekeu Mba, Yves M., Mashele, Samson S., Makhafola, Tshepiso J., McGaw, Lyndy J.

“…Despite the medicinal uses of Phragmanthera capitata, Globimetula dinklagei and Tapinanthus bangwensis against memory loss, convulsions and pain, their…”
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Five Ochna species have high antibacterial activity and more than ten antibacterial compounds by Makhafola, Tshepiso J, Eloff, Jacobus N

“…New measures to control infections in humans and other animals are continuously being sought because of the increasing resistance of bacteria to antibiotics…”
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Genotoxic effects of Dukhan: A smoke bath from the wood of Acacia seyal used traditionally by Sudanese women by Elgorashi, Esam E., Eldeen, Ibrahim M.S., Makhafola, Tshepiso J., Eloff, Jacobus N., Verschaeve, Luc

“…Smoke from the wood of Acacia seyal Delile has been used by Sudanese women for making a smoke bath locally called Dukhan. The ritual is performed to relieve…”
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Effect of solvent extraction on the antioxidant and phytochemical profiles of ellagitannins from “wonderful” pomegranate peel: an advanced chemometrics analysis by Setlhodi, Reaotshepa, Mashile, Boitumelo, Izu, Gloria O., Gbashi, Sefater, Mashele, Samson S., Bonnet, Susanna L., Makhafola, Tshepiso J., Chukwuma, Chika I.

“…Ellagitannins are the predominant bioactive tannins present in the peel of pomegranate. Studies have explored different extraction solvents to maximize…”
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Temperature‐dependent extraction and chromatographic recovery and characterisation of ellagitannins with potent antioxidant and glycaemic control properties from ‘Wonderful’ pomegranate peel by Mashile, Boitumelo, Setlhodi, Reaotshepa, Izu, Gloria O., Erukainure, Ochuko L., Mashele, Samson S., Makhafola, Tshepiso J., Eze, Kenneth C., Chukwuma, Chika I.

“…Summary Pomegranate peel contains bioactive ellagitannins including punicalagin, a major bioactive principle. However, studies have not optimally recovered and…”
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Modeling the Influence of Extraction Temperature on the Ellagitannin and Antioxidant Profiles of “Wonderful” Pomegranate Peel Using Advanced Chemometrics Analysis by Setlhodi, Reaotshepa, Mashile, Boitumelo, Izu, Gloria O., Gbashi, Sefater, Mashele, Samson S., Bonnet, Susanna L., Makhafola, Tshepiso J., Chukwuma, Chika I.

“…Pomegranate peel contains ellagitannins as antioxidant principles but the aqueous extraction temperature for optimum ellagitannins recovery and antioxidant…”
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Vanillic acid-Zn(II) complex: a novel complex with antihyperglycaemic and anti-oxidative activity by Oke, Ifedolapo M, Ramorobi, Limpho M, Mashele, Samson S, Bonnet, Susanna L, Makhafola, Tshepiso J, Eze, Kenneth C, Noreljaleel, Anwar E M, Chukwuma, Chika I

“…Our aim was to synthesize, characterize and evaluate the antihyperglycaemic and anti-oxidative properties of a new Zn(II) complex of vanillic acid. The complex…”
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Complexation potentiated promising anti‐diabetic and anti‐oxidative synergism between ZN(ii) and ferulic acid: A multimode study by Matowane, Godfrey R., Ramorobi, Limpho M., Mashele, Samson S., Bonnet, Susanna L., Noreljaleel, Anwar E. M., Swain, Shasank S., Makhafola, Tshepiso J., Chukwuma, Chika I.

“…Aim This study was done to investigate the anti‐diabetic and anti‐oxidative synergism between zinc(II) and ferulic acid through complexation. Methods Zinc…”
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A review on the medicinal potential, toxicology, and phytochemistry of litchi fruit peel and seed by Chukwuma, Chika I., Izu, Gloria O., Chukwuma, Maria S., Samson, Mashele S., Makhafola, Tshepiso J., Erukainure, Ochuko L.

“…The perception that many fruit wastes, particularly the peel, contain more phytochemicals than the edible portions has been largely supported by scientific…”
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Nutritional and phytochemical profile of pomegranate (“Wonderful variety”) peel and its effects on hepatic oxidative stress and metabolic alterations by Akuru, Eunice A., Chukwuma, Chika I., Oyeagu, Chika E., Erukainure, Ochuko L., Mashile, Boitumelo, Setlhodi, Reaotshepa, Mashele, Samson S., Makhafola, Tshepiso J., Unuofin, Jeremiah O., Abifarin, Taiwo O., Mpendulo, Thando C.

“…The peel of pomegranate fruit contains antioxidant phytochemicals that may potentiate health benefits but remain under‐explored. We evaluated the antioxidant,…”
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In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone by Mphahlele, Malose J., Makhafola, Tshepiso J., Mmonwa, Mmakwena M.

“…(i) Ar1CCH (1.2equiv), PdCl2(PPh3)2, CuI, K2CO3, 9:1 DMF:H2O (v/v), rt, 5h; (ii) ArB(OH)2, PdCl2(PPh3)2, PCy3, K2CO3, 3:1 dioxane–water (v/v), 80°C, 2h; (iii)…”
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Isolation of anti-mycobacterial compounds from Curtisia dentata (Burm.f.) C.A.Sm (Curtisiaceae) by Fadipe, Victor O, Mongalo, Nkoana I, Opoku, Andy R, Dikhoba, Preachers M, Makhafola, Tshepiso J

“…Tuberculosis is counted amongst the most infectious and lethal illnesses worldwide and remains one of the major threats to human health. The aim of the current…”
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