Search Results - "Makarov, Aleksey A"
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11-Phenylundeca-5Z,9Z-dienoic Acid: Stereoselective Synthesis and Dual Topoisomerase I/IIα Inhibition
Published in Current cancer drug targets (01-08-2015)“…(5Z,9Z)-11-Phenylundeca-5,9-dienoic acid was stereoselectively synthesized, based on original cross-cyclomagnesiation of…”
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The facile synthesis of the 5Z,9Z-dienoic acids and their topoisomerase I inhibitory activity
Published in Chemical communications (Cambridge, England) (28-09-2013)“…An original, effective approach to the synthesis of natural and synthetic 5Z,9Z-dienoic acids in high yields (61-67%) and with high selectivity (>98%) was…”
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The first total synthesis of the marine acetylenic alcohol, lembehyne B - a selective inducer of early apoptosis in leukemia cancer cells
Published in Organic & biomolecular chemistry (2017)“…The communication reports a new stereoselective method for the synthesis of a natural acetylenic alcohol, lembehyne B. The key stage of the process uses new…”
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Stereoselective synthesis of 11-phenylundeca-5Z,9Z-dienoic acid and investigation of its human topoisomerase I and IIα inhibitory activity
Published in Bioorganic & medicinal chemistry letters (01-06-2015)“…[Display omitted] (5Z,9Z)-11-Phenylundeca-5,9-dienoic acid was stereoselectively synthesized, based on original cross-cyclomagnesiation of…”
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Catalytic cyclometallation in steroid chemistry III: Synthesis of steroidal derivatives of 5Z,9Z-dienoic acid and investigation of its human topoisomerase I inhibitory activity
Published in Steroids (01-10-2015)“…Two approaches to stereoselective synthesis of steroid 5Z,9Z-dienoic acids were developed, the first one being based on the cross-cyclomagnesiation of…”
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On a class of topological conjugacy with a homothety
Published in Žurnal Srednevolžskogo matematičeskogo obŝestva (Online) (30-09-2020)“…We consider a class H(Rn) of orientation-preserving homeomorphisms of Euclidean space Rn such that for any homeomorphism h∈H(Rn) and for any point x∈Rn a…”
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Ti-catalyzed cross-cyclomagnesiation of 1,2-dienes in the stereoselective synthesis of insect pheromones
Published in Tetrahedron letters (03-05-2017)“…[Display omitted] •Z,Z-Selective syntheses of various pheromones and attractants was achieved.•Ti-catalyzed cross-cyclomagnesiation of 1,2-dienes was used as…”
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Novel organomagnesium reagents in synthesis. Catalytic cyclomagnesiation of allenes in the synthesis of N-, O-, and Si-substituted 1Z,5Z-dienes
Published in Tetrahedron (30-09-2013)“…An efficient method for the synthesis of valuable N-, O-, and Si-containing 1Z,5Z-diene compounds was developed. The method comprises Cp2TiCl2-catalyzed homo-…”
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nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα
Published in Medicinal chemistry research (01-01-2016)“…An original, effective approach to the stereoselective method for the synthesis of higher unsaturated acids containing a 1Z,5Z-diene group in 61–75 % yields…”
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The first total synthesis of lembehyne B
Published in Mendeleev communications (01-03-2017)“…[Display omitted] The total synthesis of lembehyne B was accomplished in five steps in 51% total yield. The cross-cyclomagnesiation of two allenic components,…”
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Synthesis of gigantic macrocyclic polyketones through catalytic cyclometalation of cycloalkynes
Published in Tetrahedron (21-08-2010)“…A new effective method for designing unique gigantic polyfunctional macrocarbocycles from cyclic acetylenes and Grignard reagents through the catalytic…”
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A new stereoselective synthesis of biologically active di- and trienoic acids containing a (1Z,5Z)-diene moiety
Published in Mendeleev communications (01-05-2017)“…[Display omitted] Natural (5Z,9Z)-dienoic acids and key precursors of biologically active trienoic acids were prepared in high yields and with high…”
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Catalytic cyclometallation in steroid chemistry III1Steroids 78 (12–13) (2013) 1298–1303 (http://dx.doi.org/10.1016/j.steroids.2013.09.007).1: Synthesis of steroidal derivatives of 5Z,9Z-dienoic acid and investigation of its human topoisomerase I inhibitory activity
Published in Steroids (01-10-2015)“…[Display omitted] •For the first time two approaches to stereoselective synthesis of steroid containing 5Z,9Z-dienoic acids have been developed.•High…”
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Novel Mg-organic reagents in organic synthesis. Cp 2TiCl 2 catalyzed intermolecular cyclomagnesiation of cyclic and acyclic 1,2-dienes using Grignard reagents
Published in Tetrahedron (2008)“…High-yield (>80%) catalytic intermolecular cyclomagnesiation of cyclic and acyclic allenes with the aid of Grignard reagents has been realized in the presence…”
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Synthesis of gigantic macrocyclic polyketones through catalytic cyclometalation of cycloalkynes
Published in Tetrahedron (2010)Get full text
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