Search Results - "Makarewicz, Amanda M."
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The Target of Ezetimibe Is Niemann-Pick C1-Like 1 (NPC1L1)
Published in Proceedings of the National Academy of Sciences - PNAS (07-06-2005)“…Ezetimibe is a potent inhibitor of cholesterol absorption that has been approved for the treatment of hypercholesterolemia, but its molecular target has been…”
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Journal Article -
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Accelerating Pharmaceutical Process Development with an Acoustic Droplet Ejection-Multiple Reaction Monitoring-Mass Spectrometry Workflow
Published in Analytical chemistry (Washington) (23-01-2024)“…Fast-paced pharmaceutical process developments (e.g., high-throughput experimentation, directed evolution, and machine learning) involve the introduction of…”
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Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors
Published in Bioorganic & medicinal chemistry letters (15-06-2005)“…anti-Substituted biaryl β-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors that suffer from suboptimal selectivity and…”
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Journal Article