Search Results - "Makarand Deo"

KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia by Deo, Makarand, Ruan, Yanfei, Pandit, Sandeep V., Shah, Kushal, Berenfeld, Omer, Blaufox, Andrew, Cerrone, Marina, Noujaim, Sami F., Denegri, Marco, Jalife, José, Priori, Silvia G.

“…We describe a mutation (E299V) in KCNJ2 , the gene that encodes the strong inward rectifier K ⁺ channel protein (Kir2.1), in an 11-y-old boy. The unique short…”
Get full text

Identification and characterization of two novel KCNH2 mutations contributing to long QT syndrome by Owusu-Mensah, Anthony, Treat, Jacqueline, Bernardi, Joyce, Pfeiffer, Ryan, Goodrow, Robert, Tsevi, Bright, Lam, Victoria, Audette, Michel, Cordeiro, Jonathan M, Deo, Makarand

“…We identified two different inherited mutations in KCNH2 gene, or human ether-a-go-go related gene (hERG), which are linked to Long QT Syndrome. The first…”
Get full text

Dominant Frequency Increase Rate Predicts Transition from Paroxysmal to Long-Term Persistent Atrial Fibrillation by Martins, Raphael P, Kaur, Kuljeet, Hwang, Elliot, Ramirez, Rafael J, Willis, B Cicero, Filgueiras-Rama, David, Ennis, Steven R, Takemoto, Yoshio, Ponce-Balbuena, Daniela, Zarzoso, Manuel, O’Connell, Ryan P, Musa, Hassan, Guerrero-Serna, Guadalupe, Avula, Uma Mahesh R, Swartz, Michael F, Bhushal, Sandesh, Deo, Makarand, Pandit, Sandeep V, Berenfeld, Omer, Jalife, José

“…BACKGROUND—Little is known about the mechanisms underlying the transition from paroxysmal to persistent atrial fibrillation (AF). In an ovine model of…”
Get full text

Attraction of Rotors to the Pulmonary Veins in Paroxysmal Atrial Fibrillation: A Modeling Study by Calvo, Conrado J., Deo, Makarand, Zlochiver, Sharon, Millet, José, Berenfeld, Omer

“…Maintenance of paroxysmal atrial fibrillation (AF) by fast rotors in the left atrium (LA) or at the pulmonary veins (PVs) is not fully understood. To gain…”
Get full text

An in silico hiPSC-Derived Cardiomyocyte Model Built With Genetic Algorithm by Akwaboah, Akwasi D., Tsevi, Bright, Yamlome, Pascal, Treat, Jacqueline A., Brucal-Hallare, Maila, Cordeiro, Jonathan M., Deo, Makarand

“…The formulation of in silico biophysical models generally requires optimization strategies for reproducing experimentally observed phenomena. In…”
Get full text

Towards predictive modelling of the electrophysiology of the heart by Vigmond, Edward, Vadakkumpadan, Fijoy, Gurev, Viatcheslav, Arevalo, Hermenegild, Deo, Makarand, Plank, Gernot, Trayanova, Natalia

“…The simulation of cardiac electrical function is an example of a successful integrative multiscale modelling approach that is directly relevant to human…”
Get full text

Arrhythmogenic mechanisms of the Purkinje system during electric shocks: A modeling study by Deo, Makarand, PhD, Boyle, Patrick, Plank, Gernot, PhD, Vigmond, Edward, PhD

“…Background The function of the Purkinje system (PS) is to ensure fast and uniform activation of the heart. Although this vital role during sinus rhythm is well…”
Get full text

Delayed afterdepolarization‐induced triggered activity in cardiac purkinje cells mediated through cytosolic calcium diffusion waves by Shah, Chirag, Jiwani, Sohel, Limbu, Bijay, Weinberg, Seth, Deo, Makarand

“…Cardiac Purkinje cells (PCs) are more susceptible to action potential abnormalities as compared to ventricular myocytes (VMs), which could be associated with…”
Get full text

Calcium Dynamics and Cardiac Arrhythmia by Deo, Makarand, Weinberg, Seth H, Boyle, Patrick M

“…This Special Collection will gather all studies highlighting recent advances in theoretical and experimental studies of arrhythmia, with a specific focus on…”
Get full text

A Major Role for hERG in Determining Frequency of Reentry in Neonatal Rat Ventricular Myocyte Monolayer by Hou, Luqia, Deo, Makarand, Furspan, Philip, Pandit, Sandeep V, Mironov, Sergey, Auerbach, David S, Gong, Qiuming, Zhou, Zhengfeng, Berenfeld, Omer, Jalife, José

“…RATIONALE:The rapid delayed rectifier potassium current, IKr, which flows through the human ether-a-go-go-related (hERG) channel, is a major determinant of the…”
Get full text

The ionic bases of the action potential in isolated mouse cardiac Purkinje cell by Vaidyanathan, Ravi, PhD, O’Connell, Ryan P., BS, Deo, Makarand, PhD, Milstein, Michelle L., PhD, Furspan, Philip, PhD, Herron, Todd J., PhD, Pandit, Sandeep V., PhD, Musa, Hassan, PhD, Berenfeld, Omer, PhD, Jalife, José, MD, FHRS, Anumonwo, Justus M.B., PhD

“…Background Collecting electrophysiological and molecular data from the murine conduction system presents technical challenges. Thus, only little advantage has…”
Get full text

Role of Cytosolic Calcium Diffusion in Murine Cardiac Purkinje Cells by Limbu, Bijay, Shah, Kushal, Weinberg, Seth H., Deo, Makarand

“…Cardiac Purkinje cells (PCs) are morphologically and electrophysiologically different from ventricular myocytes and, importantly, exhibit distinct calcium…”
Get full text

Hydrological Forecasting Using Neural Networks by Thirumalaiah, Konda, Deo, Makarand C

“…Operational planning of water resources systems like reservoirs and power plants calls for real-time or on-line forecasting of runoff and river stage. Most of…”
Get full text

Relative contribution of changes in sodium current versus intercellular coupling on reentry initiation in 2-dimensional preparations of plakophilin-2–deficient cardiac cells by Deo, Makarand, PhD, Sato, Priscila Y., BS, Musa, Hassan, PhD, Lin, Xianming, PhD, Pandit, Sandeep V., PhD, Delmar, Mario, MD, PhD, FHRS, Berenfeld, Omer, PhD

“…Background Loss of expression of the desmosomal protein plakophilin-2 (PKP2) leads to decreased gap junction–mediated (GJ) coupling, and alters the amplitude…”
Get full text

Effects of Fibrosis Morphology on Reentrant Ventricular Tachycardia Inducibility and Simulation Fidelity in Patient-Derived Models by Ringenberg, Jordan, Deo, Makarand, Filgueiras-Rama, David, Pizarro, Gonzalo, Ibañez, Borja, Peinado, Rafael, Merino, José L, Berenfeld, Omer, Devabhaktuni, Vijay

“…Myocardial fibrosis detected via delayed-enhanced magnetic resonance imaging (MRI) has been shown to be a strong indicator for ventricular tachycardia (VT)…”
Get full text

Inverse estimation of wind from the waves measured by high-frequency radar by Mathew, Thanu E, Deo, Makarand Chintamani

“…In this work, an attempt was made to derive wind speeds from the wave parameters recorded by a high-frequency (HF) radar by resorting to the techniques of an…”
Get full text

Corrigendum to ＂Effects of Fibrosis Morphology on Reentrant Ventricular Tachycardia Inducibility and Simulation Fidelity in Patient-Derived Models by Ringenberg, Jordan, Deo, Makarand, Filgueiras-Rama, David, Pizarro, Gonzalo, Ibañez, Borja, Peinado, Rafael, Trayanova, Natalia, Miller, Michael, Merino, José I., Berenfeld, Omer, Devabhaktuni, Vijay

Get full text

Future Geomorphologic Changes under the Changing Climate by Rajasree, Bharathan Radhamma, Deo, Makarand Chintamani

“…Rajasree, B.R. and Deo, M.C., 2020. Future geomorphologic changes under the changing climate. In: Sheela Nair, L.; Prakash, T.N.; Padmalal, D., and Kumar…”
Get full text

Abstract 12269: Investigating Arrhythmogenic Potential of a Novel KCNH2 Mutation Leading to Long QT Syndrome by Tsevi, Bright, Akwaboah, Akwasi D, Treat, Jacqueline A, Goodrow, Robert, Lam, Victoria, Owusu-Mensah, Anthony, Audette, Michel, Cordeiro, Jonathan M, Deo, Makarand

“…BackgroundMutations in the gene KCNH2 have been associated with both Short and Long QT syndrome. In this study, we identified a 1-day old infant that exhibited…”
Get full text

Fast, accurate, and fully automatic segmentation of the right ventricle in short-axis cardiac MRI by Ringenberg, Jordan, Deo, Makarand, Devabhaktuni, Vijay, Berenfeld, Omer, Boyers, Pamela, Gold, Jeffrey

“…Abstract This paper presents a fully automatic method to segment the right ventricle (RV) from short-axis cardiac MRI. A combination of a novel…”
Get full text