Search Results - "Mak, Victor W"

A Unified Strategy to ent-Kauranoid Natural Products: Total Syntheses of (−)-Trichorabdal A and (−)-Longikaurin E by Yeoman, John T. S, Mak, Victor W, Reisman, Sarah E

“…The first total syntheses of (−)-trichorabdal A and (−)-longikaurin E are reported. A unified synthetic strategy is employed that relies on a Pd-mediated…”
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Origins of Regio- and Stereochemistry in Type 2 Intramolecular N‑Acylnitroso Diels–Alder Reactions: A Computational Study of Tether Length and Substituent Effects by Cleary, Leah, Mak, Victor W, Rychnovsky, Scott D, Shea, Kenneth J, Sizemore, Nicholas

“…Quantum mechanical calculations have been used to investigate type 2 intramolecular N-acylnitroso Diels–Alder reactions. Experimentally observed…”
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Total Syntheses of the C19 Diterpenoid Alkaloids (−)-Talatisamine, (−)-Liljestrandisine, and (−)-Liljestrandinine by a Fragment Coupling Approach by Wong, Alice R, Fastuca, Nicholas J, Mak, Victor W, Kerkovius, Jeffrey K, Stevenson, Susan M, Reisman, Sarah E

“…The C19 diterpenoid alkaloids (C19 DTAs) are a large family of natural products, many of which modulate the activity of ion channels in vivo and are therefore…”
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A convergent fragment coupling strategy to access quaternary stereogenic centers by Kerkovius, Jeff K, Wong, Alice R, Mak, Victor W, Reisman, Sarah E

“…The formation of quaternary stereogenic centers via convergent fragment coupling is a longstanding challenge in organic synthesis. Here, we report a strategy…”
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A unified strategy for the synthesis of (−)-maoecrystal Z, (−)-trichorabdal A, and (−)-longikaurin E by Yeoman, John T.S., Cha, Jacob Y., Mak, Victor W., Reisman, Sarah E.

“…Herein we describe in full our investigations that led to the completion of the first total syntheses of (−)-maoecrystal Z, (−)-trichorabdal A, and…”
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Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α by Mak, Victor W., Patel, Akash M., Yen, Rose, Hanisak, Jennifer, Lim, Yeon-Hee, Bao, Jianming, Zheng, Rong, Seganish, W. Michael, Yu, Yang, Healy, David R., Ogawa, Aimie, Ren, Zhao, Soriano, Aileen, Ermakov, Grigori P., Beaumont, Maribel, Metwally, Essam, Cheng, Alan C., Verras, Andreas, Fischmann, Thierry, Zebisch, Matthias, Silvestre, H. Leonardo, McEwan, Paul A., Barker, John, Rearden, Paul, Greshock, Thomas J.

“…Activation of PKG1α is a compelling strategy for the treatment of cardiovascular diseases. As the main effector of cyclic guanosine monophosphate (cGMP),…”
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Total Syntheses of the C 19 Diterpenoid Alkaloids (-)-Talatisamine, (-)-Liljestrandisine, and (-)-Liljestrandinine by a Fragment Coupling Approach by Wong, Alice R, Fastuca, Nicholas J, Mak, Victor W, Kerkovius, Jeffrey K, Stevenson, Susan M, Reisman, Sarah E

“…The C19 diterpenoid alkaloids (C19 DTAs) are a large family of natural products, many of which modulate the activity of ion channels and are therefore of…”
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Studies toward the synthesis of (−)-stenine by Cleary, Leah, Mak, Victor W., Pitzen, Jennifer, McCallum, Monica E., Loo, Mandy M., Shea, Kenneth J.

“…[Display omitted] Herein is described an application of the acyl nitroso type 2 intramolecular Diels–Alder reaction as a key step in the progress toward the…”
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Predicting performance of parallel computations by Mak, V.W., Lundstrom, S.F.

“…An accurate and computationally efficient method for predicting the performance of a class of parallel computations running on concurrent systems is described…”
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VLSI accelerators for large database systems by Lee, K.C., Hickey, T.M., Mak, V.W., Herman, G.E.

“…An experimental VLSI accelerator research prototype designed and fabricated for relational data filtering is described. It performs high-speed associative…”
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