Search Results - "Mak, Thomas Shiu‐Kwong"
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Transforming growth factor‐β signalling in renal fibrosis: from Smads to non‐coding RNAs
Published in The Journal of physiology (15-08-2018)“…Transforming growth factor‐β (TGF‐β) is the key player in tissue fibrosis. However, antifibrotic therapy targeting this multifunctional protein may interfere…”
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Challenges and Recent Advances in NK Cell-Targeted Immunotherapies in Solid Tumors
Published in International journal of molecular sciences (23-12-2021)“…Natural killer (NK) cell is a powerful malignant cells killer, providing rapid immune responses via direct cytotoxicity without the need of antigen processing…”
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Inhibition of tumor invasion and metastasis by targeting TGF-β-Smad-MMP2 pathway with Asiatic acid and Naringenin
Published in Molecular therapy. Oncolytics (26-03-2021)“…Transforming growth factor β (TGF-β) has been shown to promote tumor invasion and metastasis by activating the matrix metalloproteinases (MMPs); however,…”
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Macrophages in Renal Fibrosis
Published in Advances in experimental medicine and biology (2019)“…Monocytes/macrophages are highly involved in the process of renal injury, repair and fibrosis in many aspects of experimental and human renal diseases…”
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Self-carried nanodrug (SCND-SIS3): A targeted therapy for lung cancer with superior biocompatibility and immune boosting effects
Published in Biomaterials (01-09-2022)“…Transforming growth factor β (TGF-β) is a well-known key mediator for the progression and metastasis of lung carcinoma. However, cost-effective anti-TGF-β…”
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Disrupting Smad3 potentiates immunostimulatory function of NK cells against lung carcinoma by promoting GM-CSF production
Published in Cellular and molecular life sciences : CMLS (15-06-2024)“…Through Smad3-dependent signalings, transforming growth factor-β (TGF-β) suppresses the development, maturation, cytokine productions and cytolytic functions…”
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Roles of Macrophage-to-Myofibroblast Transition (MMT) in Vascular Remodeling in Restenosis
Published 01-01-2020“…Restenosis is the narrowing of blood vessels leading to restricted blood flow by proliferative process similar to wound healing after procedures of angioplasty…”
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Dissertation