Applications of Genome Editing Technologies in CAD Research and Therapy with a Focus on Atherosclerosis

Applications of Genome Editing Technologies in CAD Research and Therapy with a Focus on Atherosclerosis

Cardiovascular diseases, particularly coronary artery disease (CAD), remain the leading cause of death worldwide in recent years, with myocardial infarction (MI) being the most common form of CAD. Atherosclerosis has been highlighted as one of the drivers of CAD, and much research has been carried o...

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Bibliographic Details
Published in:International journal of molecular sciences Vol. 24; no. 18; p. 14057
Main Authors: Mak, Michelle C. E, Gurung, Rijan, Foo, Roger S. Y
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-09-2023
MDPI
Subjects:
Amino acids
Anticholesteremic agents
Antilipemic agents
Apolipoproteins
Atherosclerosis
Blood clots
Cardiovascular disease
Cardiovascular diseases
Cholesterol
coronary artery disease
Coronary vessels
CRISPR
Gene loci
Genome editing
Genomes
Genomics
Health aspects
Health risk assessment
Heart attack
Heart attacks
Heart failure
Ischemia
Lipids
Low density lipoprotein
Metabolism
Mutation
Pathophysiology
Proteins
Review
Statins
Stroke
TALEN
Vein & artery diseases
ZFN
Morocco
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Summary:Cardiovascular diseases, particularly coronary artery disease (CAD), remain the leading cause of death worldwide in recent years, with myocardial infarction (MI) being the most common form of CAD. Atherosclerosis has been highlighted as one of the drivers of CAD, and much research has been carried out to understand and treat this disease. However, there remains much to be better understood and developed in treating this disease. Genome editing technologies have been widely used to establish models of disease as well as to treat various genetic disorders at their root. In this review, we aim to highlight the various ways genome editing technologies can be applied to establish models of atherosclerosis, as well as their therapeutic roles in both atherosclerosis and the clinical implications of CAD.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241814057