Retrospective quality of life study in patients with retroperitoneal sarcoma in an Asian population

Retrospective quality of life study in patients with retroperitoneal sarcoma in an Asian population

Retroperitoneal sarcoma represents 15% of sarcomas. The mainstay of treatment is surgery where a majority of patients require multi-visceral resections that may significantly impact their quality of life (QOL) following surgery. Studies in other cancers have shown that QOL may not be significantly i...

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Bibliographic Details
Published in:Health and quality of life outcomes Vol. 18; no. 1; p. 270
Main Authors: Lim, Hui Jun, Ong, Chin-Ann Johnny, Skanthakumar, Thakshayeni, Mak, Lisa Yuen Hong, Wasudevan, Seettha Devi, Tan, Joey Wee-Shan, Chia, Claramae Shulyn, Tan, Grace Hwei Ching, Teo, Melissa Ching Ching
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 06-08-2020
BioMed Central
BMC
Subjects:
Abdomen
Adult
Aged
Aged, 80 and over
Cancer
Care and treatment
Cross-Sectional Studies
Endoscopy
Evaluation
Female
Gastric cancer
Global health
Humans
Liposarcoma
Male
Medical research
Middle Aged
Patients
Pilot Projects
Quality of Life
Questionnaires
Retroperitoneal Neoplasms - psychology
Retroperitoneal Neoplasms - surgery
Retroperitoneal sarcoma
Retrospective Studies
Sarcoma
Sarcoma - psychology
Sarcoma - surgery
Singapore
Standard deviation
Studies
Surgery
Surgical oncology
Surveys and Questionnaires
Tumors
Variables
World health
Singapore
Retroperitoneal sarcoma
Surgical oncology
Quality of life
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Summary:Retroperitoneal sarcoma represents 15% of sarcomas. The mainstay of treatment is surgery where a majority of patients require multi-visceral resections that may significantly impact their quality of life (QOL) following surgery. Studies in other cancers have shown that QOL may not be significantly impacted after radical or extensive surgery. However, there are limited studies examining the QOL specifically in patients with retroperitoneal sarcoma. In this pilot study, we retrospectively evaluated the QOL of patients with retroperitoneal sarcoma. 32 out of 90 patients who underwent surgical intervention for retroperitoneal sarcoma in National Cancer Centre Singapore from January 1999 to August 2018 who were alive and on follow-up were included in this study. EORTC-QLQ-C30 was administered to the patients. The median age of our patients was 59 years (range, 35-84), and median time from surgery to the implementation of questionnaire was 2.5 years (range, 0.05-9.6). Younger patients had significantly better differences in global health, physical and role functioning scores as compared to older individuals. Female patients reported higher global health, physical, emotional and social functioning scores than males. Patients who were more than 2 years post-surgery exhibited better QOL scores as compared to those who had more recent surgery. Our patients had comparable global health and functioning scores compared to a reference group of outpatient cancer patients at our institution. Our pilot study investigating the QOL of patients with retroperitoneal sarcoma has shown that patients need to be followed up for at least 2 years following surgery to evaluate their QOL. In general, they achieved better functioning scores when compared with other cancer patients. These findings support the need for larger-scale prospective studies to further evaluate the QOL of these patients.
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ISSN:1477-7525
1477-7525
DOI:10.1186/s12955-020-01491-0